Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Stephen M. Strittmatter"'
Autor:
Hideyuki Takahashi, Azucena Perez-Canamas, Chris W. Lee, Hongping Ye, Xianlin Han, Stephen M. Strittmatter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-1
Externí odkaz:
https://doaj.org/article/2d4b84f71cc84fa498cf6557a2f49eae
Autor:
Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Hongping Ye, Xianlin Han, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie, Stephen M. Strittmatter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that reduction of progra
Externí odkaz:
https://doaj.org/article/2b805bded4424ad3b625c7336380db12
Autor:
Austin Stoner, Li Fu, LaShae Nicholson, Chao Zheng, Takuya Toyonaga, Joshua Spurrier, Will Laird, Zhengxin Cai, Stephen M. Strittmatter
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-25 (2023)
Abstract Background Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein aggregates and brain immune activation have triggering roles in synaptic failure but the neurona
Externí odkaz:
https://doaj.org/article/3623c85b0dce469790d861d7fd59b683
Autor:
Karen Perez de Arce, Adema Ribic, Dhrubajyoti Chowdhury, Katherine Watters, Garth J. Thompson, Basavaraju G. Sanganahalli, Elizabeth T. C. Lippard, Astrid Rohlmann, Stephen M. Strittmatter, Markus Missler, Fahmeed Hyder, Thomas Biederer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
LRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for
Externí odkaz:
https://doaj.org/article/dd39d5faa5084166b39c89b441a273e5
Autor:
A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-33 (2022)
Abstract Background Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function and memory in
Externí odkaz:
https://doaj.org/article/07d99d58976b4e01996ddce1ebeeb842
Autor:
Chao Zheng, Takuya Toyonaga, Baosheng Chen, LaShae Nicholson, William Mennie, Michael Liu, Joshua Spurrier, Kristin Deluca, Stephen M. Strittmatter, Richard E. Carson, Yiyun Huang, Zhengxin Cai
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionSynapse loss is one of the hallmarks of Alzheimer's disease (AD) and is associated with cognitive decline. In this study, we tested [18F]SDM-16, a novel metabolically stable SV2A PET imaging probe, in the transgenic APPswe/PS1dE9 (APP/PS1
Externí odkaz:
https://doaj.org/article/8e0dd44d63344551bb7b3a0f877d6b96
Autor:
Anthony G. Boghdadi, Joshua Spurrier, Leon Teo, Mingfeng Li, Mario Skarica, Benjamin Cao, William C. Kwan, Tobias D. Merson, Susan K. Nilsson, Nenad Sestan, Stephen M. Strittmatter, James A. Bourne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Astrocytes are important players in ischemic stroke. Here, the authors use single nuclei transcriptomics to characterise marmoset astrocytes following brain injury. At functional level, they show that NogoAexpressing astrocytes limit macrophage infil
Externí odkaz:
https://doaj.org/article/7d7d2c9ecae3430ebc0d5c40de26ce6f
Autor:
Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff
Publikováno v:
Cells, Vol 12, Iss 13, p 1734 (2023)
During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. Axonal damage includes swelling, defects in transport, and failure to clear damaged intracellular proteins,
Externí odkaz:
https://doaj.org/article/fd1f67f30de94928b8ba0eb64c0dde6f
Autor:
Maha M. Bakhuraysah, Paschalis Theotokis, Jae Young Lee, Amani A. Alrehaili, Pei-Mun Aui, William A. Figgett, Michael F. Azari, John-Paul Abou-Afech, Fabienne Mackay, Christopher Siatskas, Frank Alderuccio, Stephen M. Strittmatter, Nikolaos Grigoriadis, Steven Petratos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract We have previously reported evidence that Nogo-A activation of Nogo-receptor 1 (NgR1) can drive axonal dystrophy during the neurological progression of experimental autoimmune encephalomyelitis (EAE). However, the B-cell activating factor (B
Externí odkaz:
https://doaj.org/article/7f98d0d0bafb467bb50ba3cdc0460e71
Autor:
Takuya Toyonaga, Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Richard E. Carson, Zhengxin Cai
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The development of novel PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A) allowed for the in vivo detection of synaptic density changes, which are correlated with the progression and severity of a variety of neuropsychiatric diseases. W
Externí odkaz:
https://doaj.org/article/20e733a79ca9490d9c44eca8e328c5f1