Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Stephen M. Spaethe"'
Autor:
Jason Scott Sawyer, Michael J. Sofia, Peter W. Stengel, Steven A. Silbaugh, Stephen M. Spaethe, Sandra L. Cockerham, Alison M. Bendele, William T. Jackson, Larry L. Froelich
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 361:397-404
We examined the in vivo actions of LY293111 sodium (2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]pro poxy]phenoxy] benzoic acid sodium salt). Guinea pigs were used to evaluate the effect of this agent on (1) acute airway obstruction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c838f36c9803f8f50916cc61338f03e9
https://doi.org/10.1007/s002109900211
https://doi.org/10.1007/s002109900211
Autor:
Philip Padrid, Phillip J. Cozzi, Stephen M. Spaethe, I. Maurice Ndukwu, Alan R. Leff, Richard W. Mitchell
Publikováno v:
British Journal of Pharmacology. 123:1198-1204
1 We determined the effect of cyclosporine A (CsA) treatment on mast cell degranulation and lung resistance (RL) in vivo, and tracheal smooth muscle (TSM) contraction ex vivo after antigen challenge in sensitized cats. We also determined the direct e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d452273f1412e994ec252ba338059bd
https://doi.org/10.1038/sj.bjp.0701716
https://doi.org/10.1038/sj.bjp.0701716
2-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol leukotriene B4 receptor antagonists
Autor:
Michael J. Sofia, David K. Herron, Katrina Ann Nelson, Philip Marder, Theodore Goodson, Jerome H. Fleisch, Larry L. Froelich, Carlos R. Roman, Stephen M. Spaethe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1995-2000
A series of 2-n-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenols were prepared and shown to be potent leukotriene B4 (LTB4) receptor antagonists. They bound to the human neutrophil and guinea pig lung LTB4 receptors with high affinity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1f669ee07c369a26013a3dcb87d5bd
https://doi.org/10.1016/0960-894x(95)00340-y
https://doi.org/10.1016/0960-894x(95)00340-y
Publikováno v:
Scopus-Elsevier
Guinea pigs mechanically hyperventilated with dry gas exhibit hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-induced bronchovascular hyperpermeability (HIBVH). Tachykinins released from airway C-fiber neurons are the central mediators of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6332300ef49f8e225bf79aa07e70d516
https://doi.org/10.1152/jappl.1993.75.6.2797
https://doi.org/10.1152/jappl.1993.75.6.2797
Autor:
Jason Scott Sawyer, Floreancig Paul Edward, D. L. Jun. Saussy, Carlos R. Roman, Peter W. Stengel, Larry L. Froelich, Jerome H. Fleisch, Michael J. Sofia, Bach Nicholas J, Stephen Richard Baker, Sandra L. Cockerham, Stephen M. Spaethe, P. Marder, Elisabeth A. Schmittling, Baldwin Rf, J. A. Palkowitz, P. S. Borromeo, William T. Jackson, Steven A. Silbaugh
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47e8e4cc53aea42d384c2441d0759fcd
https://doi.org/10.1002/chin.199610155
https://doi.org/10.1002/chin.199610155
Autor:
David K. Herron, Steven A. Silbaugh, Theodore Goodson, Carlos R. Roman, Jerome H. Fleisch, Stephen M. Spaethe, Sandra L. Cockerham, David L. Saussy, Peter W. Stengel
Publikováno v:
European Journal of Pharmacology. 223:57-64
The actions of LY255283, a leukotriene (LT) B4 receptor antagonist, were examined on guinea pig lung. LTB4 and LY255283 displaced [3H]LTB4 from its binding site on lung membranes with pKi values of 9.9 and 7.0, respectively. In the functional correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64c0ad905ed148386468d0513125328
https://doi.org/10.1016/0014-2999(92)90818-o
https://doi.org/10.1016/0014-2999(92)90818-o
Publikováno v:
Biochemical Pharmacology. 44:1609-1615
Previous findings revealed greater contractile responses of guinea pig lung pleural surface strips to antigen or A23187 challenge than denuded lung parenchymal strips (lung strip devoid of any pleura). Moreover, we have identified a high density of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab9feefd64e800882bbf8a1f94635ab
https://doi.org/10.1016/0006-2952(92)90479-3
https://doi.org/10.1016/0006-2952(92)90479-3
Publikováno v:
Journal of Immunological Methods. 144:257-263
The activity of eosinophil peroxidase (EPO) is commonly employed as a measure of eosinophil activation in biologic fluids. Determination of product formation by this enzyme by end-point measurement may be affected profoundly by substrate concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6c9847edc547f1a6fbc1be74f49a4d
https://doi.org/10.1016/0022-1759(91)90094-v
https://doi.org/10.1016/0022-1759(91)90094-v
Autor:
David P. Henry, Weihua L. Russell, Stephen M. Spaethe, Carlos R. Roman, Kerry G. Bemis, Jerome H. Fleisch, L E Rinkema, Winston Stanley Marshall
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:620-625
LY171883, (1-[2-hydroxy-3-propyl-4-((4(1H-tetrazol-5-yl)butoxy)phenyl]ethanone), a leukotriene (LT) D4/E4 receptor antagonist, was assessed in comparison with two well known phosphodiesterase inhibitors, isobutylmethyl-xanthine (IBMX) and theophyllin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b388635fe39b95366f3797f98abce7
https://doi.org/10.1111/j.2042-7158.1990.tb06619.x
https://doi.org/10.1111/j.2042-7158.1990.tb06619.x
Autor:
Stephen M. Spaethe, E. L. van Alstyne, M. I. Mitchell, P. J. Barnes, David J. Evans, Brian J. O'Connor
Publikováno v:
Thorax. 51(12)
BACKGROUND: Leukotriene (LT) B4 is a potent neutrophil chemoattractant and also stimulates eosinophils in vitro, but its role in asthmatic inflammation is unknown. METHODS: The effect of the novel LTB4 receptor antagonist, LY293111, was examined usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eadaea096671ebc462a09c232a459f6
https://pubmed.ncbi.nlm.nih.gov/8994510
https://pubmed.ncbi.nlm.nih.gov/8994510