Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Stephen M. Sims"'
Publikováno v:
Bone Reports, Vol 5, Iss , Pp 70-80 (2016)
Micro-computed tomography (micro-CT) is used routinely to quantify skeletal tissue mass in small animal models. Our goal was to evaluate repeated in vivo micro-CT imaging for monitoring whole-body composition in studies of growth and aging in mice. M
Externí odkaz:
https://doaj.org/article/2786dec3819c40d480865aa6d4a163ba
Autor:
Wei-Yang Lu, Peter B. Stathopulos, Jinhui Zhu, Qingping Feng, Stephen M. Sims, Xiangru Lu, Le Gui
Publikováno v:
Paediatrics Publications
Store-operated Ca2+ entry (SOCE) mediated by stromal interacting molecule-1 (STIM1) and Orai1 represents a major route of Ca2+ entry in mammalian cells and is initiated by STIM1 oligomerization in the endoplasmic or sarcoplasmic reticulum (ER/SR). Ho
Publikováno v:
Bone Reports, Vol 5, Iss, Pp 70-80 (2016)
Micro-computed tomography (micro-CT) is used routinely to quantify skeletal tissue mass in small animal models. Our goal was to evaluate repeated in vivo micro-CT imaging for monitoring whole-body composition in studies of growth and aging in mice. M
Publikováno v:
Paediatrics Publications
Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine
Rac1 is a small GTPase and plays key roles in multiple cellular processes including the production of reactive oxygen species (ROS). However, whether Rac1 activation during myocardial ischaemia and reperfusion (I/R) contributes to arrhythmogenesis is
Autor:
Le, Gui, Jinhui, Zhu, Xiangru, Lu, Stephen M, Sims, Wei-Yang, Lu, Peter B, Stathopulos, Qingping, Feng
Publikováno v:
Journal of molecular biology. 430(12)
Store-operated Ca
Autor:
Samuel J. Dixon, Stephen M. Sims, T. Chmiel, David W. Holdsworth, Daniel Lorusso, Ryan J. Beach, Hristo N. Nikolov
Publikováno v:
Medical Imaging: Biomedical Applications in Molecular, Structural, and Functional Imaging
Mechanotransduction – the process by which cells sense and respond to mechanical stimuli – is essential for several physiological processes including skeletal homeostasis. Mammalian cells are thought to be sensitive to different modes of mechanic
Publikováno v:
Journal of Bone and Mineral Research. 29:725-734
Osteoclasts are multinucleated cells responsible for the resorption of bone and other mineralized tissues during development, physiological remodeling, and pathological bone loss. Osteoclasts have the ability to resorb substrate while concurrently mi
Autor:
Adam Kashishian, S. Jeffrey Dixon, Stephen M. Sims, Natsuko Tanabe, Alexey Pereverzev, Ryan P.P. Shugg, Kamal D. Puri, Frank R. Jirik, Brian J. Lannutti, Ashley Thomson, Bart H. Steiner
Publikováno v:
Journal of Biological Chemistry. 288:35346-35357
Phosphatidylinositol 3-kinases (PI3K) participate in numerous signaling pathways, and control distinct biological functions. Studies using pan-PI3K inhibitors suggest roles for PI3K in osteoclasts, but little is known about specific PI3K isoforms in
Autor:
Steven I. Pollmann, Kim L. Beaucage, Stephen M. Sims, Mark R. Darling, David W. Holdsworth, Matthew W. Grol, Ryan J. Beach, S. Jeffrey Dixon, Andrew Xiao
Publikováno v:
Purinergic Signalling. 10:291-304
The P2X7 receptor is an ATP-gated cation channel expressed by a number of cell types. We have shown previously that disruption of P2X7 receptor function results in downregulation of osteogenic markers and upregulation of adipogenic markers in calvari
Autor:
S. Jeffrey Dixon, Jaques S. Milner, Noelle M. Ochotny, David W. Holdsworth, Daniel Lorusso, Stephen M. Sims, Hristo N. Nikolov
Publikováno v:
Biomedical microdevices. 18(5)
We describe a simple fabrication technique - targeted towards non-specialists - that allows for the production of leak-proof polydimethylsiloxane (PDMS) microfluidic devices that are compatible with live-cell microscopy. Thin PDMS base membranes were