Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Stephen M. Moerlein"'
Autor:
Mark N. Warden, Susan Searles Nielsen, Joel S. Perlmutter, Stephen M. Moerlein, Jason Lenox-Krug, Susan R. Criswell, Wendy W. Dlamini, Lianne Sheppard, Harvey Checkoway, Brad A. Racette
Publikováno v:
Toxicol Sci
The relationships between the neurotoxicant manganese (Mn), dopaminergic pathology, and parkinsonism remain unclear. Therefore, we used [11C](N-methyl)benperidol (NMB) positron emission tomography to investigate the associations between Mn exposure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e5583388c7630ba464ba6415ca5d47
https://doi.org/10.1093/toxsci/kfab045
https://doi.org/10.1093/toxsci/kfab045
Autor:
Sarah A Eisenstein, Danuta M Gredysa, Jo Ann Antenor-Dorsey, Leonard Green, Ana Maria Arbeláez, Jonathan M Koller, Kevin J Black, Joel S Perlmutter, Stephen M Moerlein, Tamara Hershey
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147063 (2016)
Externí odkaz:
https://doaj.org/article/16e61b483d1b42c19e5c9cbff04ddea3
Autor:
Sarah A Eisenstein, Danuta M Gredysa, Jo Ann Antenor-Dorsey, Leonard Green, Ana Maria Arbeláez, Jonathan M Koller, Kevin J Black, Joel S Perlmutter, Stephen M Moerlein, Tamara Hershey
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133621 (2015)
Animal research finds that insulin regulates dopamine signaling and reward behavior, but similar research in humans is lacking. We investigated whether individual differences in body mass index, percent body fat, pancreatic β-cell function, and dopa
Externí odkaz:
https://doaj.org/article/94c24b56551043de919f3ec3090574f8
Autor:
LinLin Tian, Yuanxuan Xia, Hubert P Flores, Meghan C Campbell, Stephen M Moerlein, Joel S Perlmutter
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132064 (2015)
Apathy commonly occurs in Parkinson disease (PD) patients; however, the role of dopamine in the pathophysiology of apathy remains elusive. We previously demonstrated that dopaminergic dysfunction within the ventral tegmental area (VTA)-nucleus accumb
Externí odkaz:
https://doaj.org/article/d39a8ebf3df04e3da28cb4ab3d03474f
Autor:
Kevin J Black, Abraham Z Snyder, Jonathan W Mink, Veeral N Tolia, Fredy J Revilla, Stephen M Moerlein, Joel S Perlmutter
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88121 (2014)
The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, wh
Externí odkaz:
https://doaj.org/article/666194a37b3e40908b5c92274be195f4
Publikováno v:
PET/CT and PET/MR in Melanoma and Sarcoma ISBN: 9783030604288
Although metabolic imaging with the PET radiopharmaceutical 2-[18F]fluoro-2-deoxyglucose (FDG) has been successfully used for the evaluation of melanoma and sarcoma, there is interest within the nuclear medicine community in the development of novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5ff4c4a5e74f0a186e2ccc51250bd37
https://doi.org/10.1007/978-3-030-60429-5_10
https://doi.org/10.1007/978-3-030-60429-5_10
Autor:
Joel S. Perlmutter, Susan Searles Nielsen, Jason Lenox-Krug, Lianne Sheppard, Stephen M. Moerlein, Susan R. Criswell, Brad A. Racette, Mark N. Warden, Harvey Checkoway
Publikováno v:
J Occup Environ Med
OBJECTIVE: To understand the neurotoxic effects of manganese (Mn) exposure on monoaminergic function, utilizing [(11)C]dihydrotetrabenazine (DTBZ) positron emission tomography (PET) to measure vesicular monoamine transporter 2 (VMAT2). METHODS: Basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d9c1f063fadc8705eec1e241906faa
https://europepmc.org/articles/PMC7786890/
https://europepmc.org/articles/PMC7786890/
Autor:
Susan Searles Nielsen, Susan R. Criswell, Lianne Sheppard, John L Huang, Brad A. Racette, Harvey Checkoway, Mark N. Warden, Stephen M. Moerlein, Noah S. Seixas, Hubert P. Flores, Joel S. Perlmutter
Publikováno v:
NeuroToxicology. 64:43-49
Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e3dbfe45abe7b8bc3ce40cf0b5b8a9
https://doi.org/10.1016/j.neuro.2017.07.004
https://doi.org/10.1016/j.neuro.2017.07.004
Autor:
Stephen M. Moerlein, Ryan Bogdan, Kevin J. Black, M Deanna, Tamara Hershey, Jonathan M. Koller, Nadia S. Corral-Frías, Joel S. Perlmutter, Latisha Love-Gregory, Sarah A. Eisenstein
Publikováno v:
Synapse. 70:418-431
In humans, the A1 (T) allele of the dopamine (DA) D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) TaqIA (rs1800497) single nucleotide polymorphism has been associated with reduced striatal DA D2/D3 receptor (D2/D3R) availabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6efdd439cedb4c4d52549b14f183bf2
https://doi.org/10.1002/syn.21916
https://doi.org/10.1002/syn.21916
Autor:
Sarah A. Eisenstein, Kevin J. Black, Stephen M. Moerlein, Marta Yanina Pepino, Samuel Klein, Allison N. Bischoff, Joel S. Perlmutter, Tamara Hershey
Publikováno v:
Diabetes
Alterations in dopaminergic circuitry play a critical role in food reward and may contribute to susceptibility to obesity. Ingestion of sweets releases dopamine in striatum, and both sweet preferences and striatal D2 receptors (D2R) decline with age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d83bf8935a9653434e3d6ce6bdcd74a
https://doi.org/10.2337/db16-0407
https://doi.org/10.2337/db16-0407