Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

Autor: Yingxue Li, Wei Xu, Yutian Ren, Hung-Chi Cheung, Panpan Huang, Guneet Kaur, Chih-Jung Kuo, Sean P. McDonough, Susan L. Fubini, Stephen M. Lipkin, Xin Deng, Yung-Fu Chang, Linfeng Huang

Publikováno v: mBio, Vol 13, Iss 5 (2022)

ABSTRACT Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis. TcdB, one of the essential virulence factors secreted by this bacteri

Externí odkaz: https://doaj.org/article/f893863f5bbe4b2a82abc1479b583357

American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.

Autor: Robson ME; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ. robsonm@mskcc.org., Bradbury AR; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Arun B; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Domchek SM; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Ford JM; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Hampel HL; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Lipkin SM; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Syngal S; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Wollins DS; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ., Lindor NM; Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Nov 01; Vol. 33 (31), pp. 3660-7. Date of Electronic Publication: 2015 Aug 31.