Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Stephen M. Lewis"'
Autor:
Jeremy W. Roy, Gabriel Wajnberg, Alexie Ouellette, Julie Emilie Boucher, Jacynthe Lacroix, Simi Chacko, Anirban Ghosh, Rodney J. Ouellette, Stephen M. Lewis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) has a high fatality rate, mainly due to its asymptomatic nature until late-stage disease and therefore delayed diagnosis that leads to a lack of timely treatment intervention. Consequently, there is a
Externí odkaz:
https://doaj.org/article/0ca535ccff4049feb9090645f5e80460
Autor:
Modeline N. Longjohn, Jo-Anna B. J. Hudson, Lourdes Peña-Castillo, Robert P. J. Cormier, Brandon Hannay, Simi Chacko, Stephen M. Lewis, Paul C. Moorehead, Sherri L. Christian
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Pediatric B-acute lymphoblastic leukemia (B-ALL) is a disease of abnormally growing B lymphoblasts. Here we hypothesized that extracellular vesicles (EVs), which are nanosized particles released by all cells (including cancer cells), could be used to
Externí odkaz:
https://doaj.org/article/0206816f2bc04a5a92870c93598d1fef
Autor:
Gabriel Wajnberg, Eric P. Allain, Jeremy W. Roy, Shruti Srivastava, Daniel Saucier, Pier Morin, Alier Marrero, Colleen O’Connell, Anirban Ghosh, Stephen M. Lewis, Rodney J. Ouellette, Nicolas Crapoulet
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2023)
RNA sequencing analysis is an important field in the study of extracellular vesicles (EVs), as these particles contain a variety of RNA species that may have diagnostic, prognostic and predictive value. Many of the bioinformatics tools currently used
Externí odkaz:
https://doaj.org/article/25203c6510e94eb1b769c6c31a326ea8
Autor:
Jeremy W. Roy, Catherine A. Taylor, Annie P. Beauregard, Surendar R. Dhadi, D. Craig Ayre, Sheena Fry, Simi Chacko, Gabriel Wajnberg, Andrew P. Joy, Ngoc-Nu Mai-Thi, Nicolas Crapoulet, David A. Barnett, Anirban Ghosh, Stephen M. Lewis, Rodney J. Ouellette
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Extracellular vesicles (EVs) have been recognized as a rich material for the analysis of DNA, RNA, and protein biomarkers. A remaining challenge for the deployment of EV-based diagnostic and prognostic assays in liquid biopsy testing is the
Externí odkaz:
https://doaj.org/article/e9305174dbe849828499522865518299
Autor:
Charles E. Bullerwell, Philippe Pierre Robichaud, Pierre M. L. Deprez, Andrew P. Joy, Gabriel Wajnberg, Darwin D’Souza, Simi Chacko, Sébastien Fournier, Nicolas Crapoulet, David A. Barnett, Stephen M. Lewis, Rodney J. Ouellette
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract PAX5 and EBF1 work synergistically to regulate genes that are involved in B lymphocyte differentiation. We used the KIS-1 diffuse large B cell lymphoma cell line, which is reported to have elevated levels of PAX5 expression, to investigate t
Externí odkaz:
https://doaj.org/article/5b11cbd215904b91952bccb6c01327a7
Autor:
Awanit Kumar, Surendar Reddy Dhadi, Ngoc‐Nu Mai, Catherine Taylor, Jeremy W. Roy, David A. Barnett, Stephen M. Lewis, Anirban Ghosh, Rodney J. Ouellette
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 11, Pp n/a-n/a (2021)
Abstract Several studies have demonstrated the potential uses of extracellular vesicles (EVs) for liquid biopsy‐based diagnostic tests and therapeutic applications; however, clinical use of EVs presents a challenge as many currently‐available EV
Externí odkaz:
https://doaj.org/article/e982590efd364d1b93a8b598c63d8b1f
Autor:
Nicole C. Smith, Gabriel Wajnberg, Simi Chacko, Nardos T. Woldemariam, Jacynthe Lacroix, Nicolas Crapoulet, D. Craig Ayre, Stephen M. Lewis, Matthew L. Rise, Rune Andreassen, Sherri L. Christian
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cell-derived extracellular vesicles (EVs) participate in cell-cell communication via transfer of molecular cargo including genetic material like miRNAs. In mammals, it has previously been established that EV-mediated transfer of miRNAs can alter the
Externí odkaz:
https://doaj.org/article/f758101d7eb444e9b24c1a159dab85da
Autor:
D. Craig Ayre, Ian C. Chute, Andrew P. Joy, David A. Barnett, Andrew M. Hogan, Marc P. Grüll, Lourdes Peña-Castillo, Andrew S. Lang, Stephen M. Lewis, Sherri L. Christian
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract The CD24 cell surface receptor promotes apoptosis in developing B cells, and we recently found that it induces B cells to release plasma membrane-derived, CD24-bearing microvesicles (MVs). Here we have performed a systematic characterization
Externí odkaz:
https://doaj.org/article/5fdc4db9bd1d46f7b03db8910ae362c7
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Cyberbiosecurity lies at the intersection of cybersecurity and biosecurity and addresses the protection of valuable biological material and associated information. As an emerging concept, cyberbiosecurity requires the integration of training strategi
Externí odkaz:
https://doaj.org/article/ecdf3add7b904a91ab0f1cd2fadd37f8
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
The life sciences now interface broadly with information technology (IT) and cybersecurity. This convergence is a key driver in the explosion of biotechnology research and its industrial applications in health care, agriculture, manufacturing, automa
Externí odkaz:
https://doaj.org/article/a55af777c9f542739b156801f14d40bc