Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Stephen M. Gentleman"'
Autor:
Ilse S. Pienaar, Cecilia Heyne Lee, Joanna L. Elson, Louisa McGuinness, Stephen M. Gentleman, Raj N. Kalaria, David T. Dexter
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 392-405 (2015)
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an accepted treatment for motor symptoms in a subset of Parkinson's disease (PD) patients. The mechanisms why DBS is effective are incompletely understood, but previous studies
Externí odkaz:
https://doaj.org/article/86cbc8150e8048b786c474f66ca51211
Autor:
Desmond T. Walsh, Rosa M. Montero, Laura G. Bresciani, Angela Y.T. Jen, Pascale D. Leclercq, Debbie Saunders, Ahmed N. EL-Amir, Lukemann Gbadamoshi, Stephen M. Gentleman, Ling-Sun Jen
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 1, Pp 20-27 (2002)
We have studied the neurotoxicity of amyloid-beta (Aβ) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout the photoreceptor layer and the inner nuclear layer but not in the ganglion cell layer at
Externí odkaz:
https://doaj.org/article/3a8d57f3165b469a9d297e22dcd8aff4
Differential effects of interleukin-1β and S100B on amyloid precursor protein in rat retinal neurons
Autor:
Peter JB Anderson, Helena R Watts, Sheila Jen, Stephen M Gentleman, Juliet A Moncaster, et al
Publikováno v:
Clinical Ophthalmology, Vol 2009, Iss default, Pp 235-242 (2009)
Peter JB Anderson1, Helena R Watts1, Sheila Jen1, Stephen M Gentleman2, Juliet A Moncaster1, et al1Department of Cellular and Molecular Neuroscience and 2Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial Colleg
Externí odkaz:
https://doaj.org/article/f2d1499bece1484397c7a4f9e0ce24c8
Publikováno v:
Biomechanics and Modeling in Mechanobiology
The mechanical characterization of brain tissue is a complex task that scientists have tried to accomplish for over 50 years. The results in the literature often differ by orders of magnitude because of the lack of a standard testing protocol. Differ
Publikováno v:
Acta Neuropathologica. 127:53-69
It is well established that cigarette smoking is hazardous to health and is a risk factor for many chronic diseases. However, its impact on the brain, whether it be from prenatal exposure to maternal cigarette smoking, cerebrovascular disease, Alzhei
Autor:
Isidro Ferrer, Nenad Bogdanovic, Gabor G. Kovacs, Stephen M. Gentleman, Nikolaos Kavantzas, Elisabet Englund, Kurt A. Jellinger, Andrew P. King, Romana Höftberger, Efstratios Patsouris, Annemieke J. M. Rozemuller, Nathalie Streichenberger, Stephen B. Wharton, Camelia M. Monoranu, Thomas Arzberger, Ellen Gelpi, Hans A. Kretzschmar, Safa Al-Sarraj, Manuel B. Graeber, Johannes Attems, Istvan Bodi, Penelope Korkolopoulou, Piero Parchi, James W. Ironside, Herbert Budka, David Meyronet, Giorgio Giaccone, Irina Alafuzoff, Tibor Hortobágyi, Dietmar Rudolf Thal, Danielle Seilhean, Wolfgang Roggendorf, Orso Bugiani
Publikováno v:
Experimental Gerontology. 47:825-833
Here, we summarise the results after carrying out a large survey regarding the assessment of vascular alterations, both vessel changes and vascular lesions in an inter-laboratory setting. In total, 32 neuropathologists from 22 centres, most being mem
Publikováno v:
Neuroscience Letters. 461:12-15
Dementia and visual hallucinations are common complications of Parkinson's disease (PD), yet their patho-anatomical bases are poorly defined. We studied alpha-synuclein (alphaSyn), tau and amyloid-beta (Abeta) pathology in the claustrum of 20 PD case
Autor:
R.K.B. Pearce, Stephen M. Gentleman, Linda B. Moran, M.E. Kalaitzakis, Manuel B. Graeber, L.M. Christian
Publikováno v:
Parkinsonism & Related Disorders. 15:196-204
The pathological basis of dementia and visual hallucinations in Parkinson's disease (PD) is not yet fully understood. To investigate this further we have conducted a clinico-pathological study based on 30 post-mortem PD brains. PD cases were stratifi
Autor:
Ling-Sun Jen, Stephen M. Gentleman, Okezie I. Aruoma, Sheila S.M. Jen, Helena R. Watts, Joseph George, Peter J. B. Anderson
Publikováno v:
Toxicology. 256:92-100
The potential cytotoxic effect of aggregated Abeta(1-42) to neurons that express classical neurotransmitters, including acetylcholine, gamma-amino butyric acid, catecholamines and serotonin was assessed. The cholinergic system has been the central fo
Publikováno v:
Acta Neuropathologica. 116:125-128