Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Stephen M. Dilworth"'
Autor:
Roberto Dina, Olli Vainio, Adolfo Rivero-Müller, Victoria Sharp, Sadaf Ghaem-Maghami, Ilpo Huhtaniemi, Marcin Chrusciel, Xiangdong Li, Stephen M. Dilworth, Antti Ellonen, Nafis A. Rahman, Herjan J.T. Coelingh Bennink, Yvette Zimmerman
Publikováno v:
The FASEB Journal. 26:324-333
We tested the principle of treating malignant ovarian tumors by vaccination against their ectopically expressed protein, zona pellucida glycoprotein (ZP) 3, using as the experimental model the granulosa cell tumors that develop in transgenic mice exp
Autor:
Stephen M. Dilworth, Natalia Ichaso, Adam Adamarek, Jitka Forstová, N J Dibb, Vojtech Zila, Alice Y. Zhou
Publikováno v:
Journal of Virology. 85:3046-3054
Murine polyomavirus middle T-antigen (MT) induces tumors by mimicking an activated growth factor receptor. An essential component of this action is a 22-amino-acid hydrophobic region close to the C terminus which locates MT to cell membranes. Here, w
Publikováno v:
Molecular and Cellular Biochemistry. 332:207-213
Long-term survival of oxygen deprivation by animals with well-developed anoxia tolerance depends on multiple biochemical adaptations including strong metabolic rate depression. We investigated whether the AMP-activated protein kinase (AMPK) could pla
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4418-4426
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, but its etiology remains obscure. Recent data suggest that an intrinsic abnormality of early follicle development in the ovary is key to the pathogenesis of PCOS. We hav
Autor:
Karen Zwaenepoel, Sari Longin, Veerle Janssens, Justin Vijay Louis, Jozef Goris, Stephen M. Dilworth
Publikováno v:
Journal of Biological Chemistry. 282:26971-26980
Protein phosphatase 2A (PP2A) is a family of multifunctional serine/threonine phosphatases all composed of a catalytic C, a structural A, and a regulatory B subunit. Assembly of the complex with the appropriate B subunit forms the key to the function
Publikováno v:
Oncogene. 24:7830-7838
Protein kinase B (PKB) or Akt is one of several second messenger kinases that are activated by cell attachment and growth factor signaling, and that transmit signals to the cell nucleus to inhibit apoptosis and thereby increase cell survival during p
Publikováno v:
Nature Reviews Cancer. 4:718-727
The cytoplasmic serine/threonine kinase BRAF and receptor tyrosine kinases of the platelet-derived growth factor receptor (PDGFR) family are frequently activated in cancer by mutations of an equivalent amino acid. Structural studies have provided imp
Autor:
Christine Van Hoof, Jozef Goris, Ilse Stevens, Veerle Janssens, Stephen M. Dilworth, Ellen Martens
Publikováno v:
European Journal of Biochemistry. 270:376-387
Protein phosphatase 2A is a phosphoserine/threonine phosphatase implicated in many cellular processes. The core enzyme comprises a catalytic and a PR65/A-subunit. The substrate specificity and subcellular localization are determined by a third regula
Publikováno v:
FEBS Letters. 516:265-269
The protein phosphatases PP1(c), PP2A(c) and PP2Calpha are shown to dephosphorylate protein kinase Cdelta (PKCdelta) in vitro; of these PP2A(c) displayed the highest specific activity towards PKCdelta. The role of PP2A(c) in the dephosphorylation of
Publikováno v:
Journal of Biomedical Research
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies. The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue.Normal e