Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Stephen M. Blowers"'
The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists
Autor:
Gillian Elizabeth Lunniss, Dino Montanari, Laura Caberlotto, Gemma V. Puckey, Ian Peter Holmes, Nick Barton, Ashley A. Barnes, Stephen M. Blowers, John Willis, Roz Norris, Federica Bianchi, Steve P. Watson, Dewi J. Walters, Matteo Biagetti, Amanda Emmons
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(24)
The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.
Autor:
Martyn D. Wood, Daniele Donati, Steve P. Watson, Claire M. Howes, Payne Andrew H, Patrick M. Woollard, Silvia Terreni, Romano Di Fabio, Ian Peter Holmes, Charlie Reavill, Andy Gribble, Angela Worby, Richard Blunt, Luca Arista, Stephen M. Blowers, Olivier Lorthioir, Dieter Hamprecht, Ian Stansfield, Fabrizio Micheli
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
The identification of a highly selective D 2 partial agonist, D 3 antagonist tool molecule which demonstrates high levels of brain exposure and selectivity against an extensive range of dopamine, serotonin, adrenergic, histamine, and muscarinic recep