Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Stephen M Rawlinson"'
Autor:
Gayathri Manokaran, Michelle D Audsley, Haruka Funakoda, Cassandra T David, Katherine A Garnham, Stephen M Rawlinson, Celine Deffrasnes, Naoto Ito, Gregory W Moseley
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010533 (2022)
Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies virus (RABV) and other viruses, and involves interference in the IFN induction and signaling pathways in infected cells, as well as deactivation of the ant
Externí odkaz:
https://doaj.org/article/38bb142f9a684fadbe3d07c7a9074010
Autor:
Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David B Ascher, Gregory W Moseley, Paul R Gooley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009729 (2021)
Rabies virus phosphoprotein (P protein) is a multifunctional protein that plays key roles in replication as the polymerase cofactor that binds to the complex of viral genomic RNA and the nucleoprotein (N protein), and in evading the innate immune res
Externí odkaz:
https://doaj.org/article/04e7c1bd948047038f0c27a6d86a6c67
Autor:
Angela R Harrison, Shawn Todd, Megan Dearnley, Cassandra T David, Diane Green, Stephen M Rawlinson, Gough G Au, Glenn A Marsh, Gregory W Moseley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Externí odkaz:
https://doaj.org/article/6a44e7cad2ea494cb7e0e6761ab7e59a
Autor:
Stephen M. Rawlinson, Tianyue Zhao, Ashley M. Rozario, Christina L. Rootes, Paul J. McMillan, Anthony W. Purcell, Amanda Woon, Glenn A. Marsh, Kim G. Lieu, Lin-Fa Wang, Hans J. Netter, Toby D. M. Bell, Cameron R. Stewart, Gregory W. Moseley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Many RNA viruses that replicate in the cytoplasm express proteins that localize to nucleoli, but the nucleolar functions remain largely unknown. Here, the authors show that the Henipavirus matrix protein mimics an endogenous Treacle partner of the DN
Externí odkaz:
https://doaj.org/article/f56415c38df4400f9a9e20a5ceee7848
Publikováno v:
Viruses, Vol 13, Iss 8, p 1650 (2021)
Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication. The Ebola virus IFN antagonist VP24 mediates nucleocapsid assembly, and inhibits IFN-a
Externí odkaz:
https://doaj.org/article/e6d12b7a180848259a647f0c532fc63c
Autor:
Md. Alamgir Hossain, Florence Larrous, Stephen M. Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G. Lieu, Yee-Foong Mok, Michael D.W. Griffin, Naoto Ito, Toyoyuki Ose, Hervé Bourhy, Gregory W. Moseley, Paul R. Gooley
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1934-1945.e8 (2019)
Summary: To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of pathogenesis. Because of a lack of direct structural data, these interfaces are poorly understood. We report the st
Externí odkaz:
https://doaj.org/article/fb90375ce8c54d2b8e0643781f732fb3
Autor:
Ashish Sethi, Stephen M. Rawlinson, Abhinav Dubey, Ching-Seng Ang, Yoon Hee Choi, Fei Yan, Kazuma Okada, Ashley M. Rozario, Aaron M. Brice, Naoto Ito, Nicholas A. Williamson, Danny M. Hatters, Toby D. M. Bell, Haribabu Arthanari, Gregory W. Moseley, Paul R. Gooley
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Viruses form extensive interfaces with host proteins to modulate the biology of the infected cell, frequently via multifunctional viral proteins. These proteins are conventionally considered as assemblies of independent functional modules, where the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8410a13ea88cc4f97f3019f26c089d1
https://doi.org/10.1073/pnas.2217066120
https://doi.org/10.1073/pnas.2217066120
Henipaviruses and lyssaviruses target nucleolar treacle protein and regulate ribosomal RNA synthesis
Autor:
Stephen M. Rawlinson, Tianyue Zhao, Katie Ardipradja, Yilin Zhang, Patrick F. Veugelers, Jennifer A. Harper, Cassandra T. David, Vinod Sundaramoorthy, Gregory W. Moseley
Publikováno v:
Traffic (Copenhagen, Denmark)REFERENCES.
The nucleolus is a common target of viruses and viral proteins, but for many viruses the functional outcomes and significance of this targeting remains unresolved. Recently, the first intranucleolar function of a protein of a cytoplasmically-replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ede48eeba004952ec168f28ed48840
https://pubmed.ncbi.nlm.nih.gov/36479968
https://pubmed.ncbi.nlm.nih.gov/36479968
Autor:
Aaron M. Brice, Ashley M. Rozario, Stephen M. Rawlinson, Cassandra T. David, Linda Wiltzer-Bach, David A. Jans, Naoto Ito, Toby D. M. Bell, Gregory W. Moseley
Publikováno v:
J Virol
Viral hijacking of microtubule (MT)-dependent transport is well understood, but several viruses also express discrete MT-associated proteins (vMAPs), potentially to modulate MT-dependent processes in the host cell. Specific roles for vMAP-MT interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21565a0cbe7f45fd439843bc46ec16d1
https://europepmc.org/articles/PMC9599249/
https://europepmc.org/articles/PMC9599249/
Autor:
Gayathri Manokaran, Michelle D. Audsley, Haruka Funakoda, Cassandra T. David, Katherine A. Garnham, Stephen M. Rawlinson, Celine Deffrasnes, Naoto Ito, Gregory W. Moseley
Publikováno v:
PLoS pathogens. 18(5)
Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies virus (RABV) and other viruses, and involves interference in the IFN induction and signaling pathways in infected cells, as well as deactivation of the ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b282850aa955f11a016bf6c35bd994ff
https://pubmed.ncbi.nlm.nih.gov/35576230
https://pubmed.ncbi.nlm.nih.gov/35576230