Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Stephen M F, Jamieson"'
Autor:
Tet Woo Lee, Dean C. Singleton, Julia K. Harms, Man Lu, Sarah P. McManaway, Amy Lai, Moana Tercel, Frederik B. Pruijn, Andrew M. J. Macann, Francis W. Hunter, William R. Wilson, Stephen M. F. Jamieson
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1885-1903 (2024)
Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies require selection biomarkers and preclinical models that can accurately model
Externí odkaz:
https://doaj.org/article/8463ca23a4994262a7d8bf8b809ac374
Autor:
Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P. Hay
Publikováno v:
Molecules, Vol 28, Iss 11, p 4457 (2023)
The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiother
Externí odkaz:
https://doaj.org/article/4764aa3eb15346ccaeda89c53387ec2a
Autor:
Lewis P. M. Green, Tasha R. Steel, Mie Riisom, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson, L. James Wright, James D. Crowley, Christian G. Hartinger
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series
Externí odkaz:
https://doaj.org/article/a21f05c5e4db47739cd389b575891a47
Autor:
Lynn S. Lisboa, Mie Riisom, Roan A. S. Vasdev, Stephen M. F. Jamieson, L. James Wright, Christian G. Hartinger, James D. Crowley
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/3bb6755fd37f49ab909b2c9bc734637c
Autor:
Lynn S. Lisboa, Mie Riisom, Roan A. S. Vasdev, Stephen M. F. Jamieson, L. James Wright, Christian G. Hartinger, James D. Crowley
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Two new di(2,2′-bipyridine) ligands, 2,6-bis([2,2′-bipyridin]-5-ylethynyl)pyridine (L1) and bis(4-([2,2′-bipyridin]-5-ylethynyl)phenyl)methane (L2) were synthesized and used to generate two metallosupramolecular [Fe2(L)3](BF4)4 cylinders. The l
Externí odkaz:
https://doaj.org/article/c04d97b14e8d46c7aa5570d386a6ba85
Autor:
Matthew P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. Herbert, Kelvin K. H. Tong, Jonathan W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. Goldstone, Christian G. Hartinger
Publikováno v:
Dalton Transactions. 52:1388-1392
Substitution of a labile Cl− for an NHC ligand in DNA-intercalating [Pt(terpyridine)]+ complexes improved the cytotoxicity and cellular accumulation, while in vivo studies indicated good tolerability in zebrafish.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43de307e62c5394f68bdd21d6142c646
https://doi.org/10.1039/d2dt02539f
https://doi.org/10.1039/d2dt02539f
Autor:
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger
Publikováno v:
Inorganic Chemistry. 61:17226-17241
The substitution of phenyl rings in established drugs with ferrocenyl moieties has been reported to yield compounds with improved biological activity and alternative modes of action, often involving the formation of reactive oxygen species (ROS). Tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a042348c5065431170f35e6b36d6deb
https://doi.org/10.1021/acs.inorgchem.2c02832
https://doi.org/10.1021/acs.inorgchem.2c02832
Autor:
Hay, Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P.
Publikováno v:
Molecules; Volume 28; Issue 11; Pages: 4457
The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::1ed5b9b73b3942990e64855b2a8de648
Autor:
Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger
Publikováno v:
Molecules, Vol 26, Iss 4, p 833 (2021)
RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate
Externí odkaz:
https://doaj.org/article/0c29b966a1e74fa9bb1d5c7c6222e631
Autor:
Md. Salman Shakil, Shahida Parveen, Zohaib Rana, Fearghal Walsh, Sanam Movassaghi, Tilo Söhnel, Mayur Azam, Muhammad Ashraf Shaheen, Stephen M. F. Jamieson, Muhammad Hanif, Rhonda J. Rosengren, Christian G. Hartinger
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 123 (2021)
Hydroxypyr(id)ones are a pharmaceutically important class of compounds that have shown potential in diverse areas of drug discovery. We investigated the 3-hydroxy-4-pyridones 1a–1c and 3-hydroxy-4-thiopyridones 1d–1f as well as their Ru(η6-p-cym
Externí odkaz:
https://doaj.org/article/3583fd1cf73c490da2a40080e038b220