Výsledky vyhledávání - "Stephen M Eacker"

Akademický článek

Neuronal activity regulates hippocampal miRNA expression.

Autor: Stephen M Eacker, Matthew J Keuss, Eugene Berezikov, Valina L Dawson, Ted M Dawson

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25068 (2011)

Neuronal activity regulates a broad range of processes in the hippocampus, including the precise regulation of translation. Disruptions in proper translational control in the nervous system are associated with a variety of disorders that fall in the

Externí odkaz: https://doaj.org/article/fa6ebfe00b3d4e26b0de414556899d4e

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CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders

Autor: Valina L. Dawson, Guo Li Ming, Kimberly M. Christian, Stephanie J. Temme, Weidong Li, Stephen M. Eacker, Kuei Sen Hsu, Stefan Canzar, Ki Jun Yoon, Francisca Rojas Ringeling, Ted M. Dawson, Ha Nam Nguyen, Bo Xiao, Paul F. Worley, Yu Ting Lin, Namshik Kim, Hongjun Song, Ying Zhou

Publikováno v: Biological Psychiatry. 92:815-826

Background Gene dosage imbalance caused by copy number variations (CNVs) is a prominent contributor to brain disorders. In particular, 15q11.2 CNV duplications and deletions have been associated with autism spectrum disorder and schizophrenia, respec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9e80e80885ae6100fe7ea922e66a0f
https://doi.org/10.1016/j.biopsych.2021.04.023

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High-Quality Assemblies for Three Invasive Social Wasps from the Vespula Genus

Publikováno v: G3: Genes|Genomes|Genetics
G3 (Bethesda, Md.), vol 10, iss 10
G3: Genes, Genomes, Genetics, Vol 10, Iss 10, Pp 3479-3488 (2020)

Social wasps of the genus Vespula have spread to nearly all landmasses worldwide and have become significant pests in their introduced ranges, affecting economies and biodiversity. Comprehensive genome assemblies and annotations for these species are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c93cc1e1d78ebf76ce115a2d1ef8a7d
http://europepmc.org/articles/PMC7534447

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Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains

Autor: Jungwoo Wren Kim, Yulan Xiong, Stephen M. Eacker, Valina L. Dawson, Xiling Yin, Ted M. Dawson, Ian Martin, Nicholas T. Ingolia

Publikováno v: eNeuro

Visual Abstract
The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) causes familial Parkinson’s disease (PD) and is also found in a subset of idiopathic cases. Prior studies in Drosophila and human induced pluripotent stem cell (iPSC)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98afe5d40ca2e4c3818c0c18e71e6699
http://europepmc.org/articles/PMC8638676

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Accurate viral genome reconstruction and host assignment with proximity-ligation sequencing

Autor: Benjamin Auch, Ivan Liachko, Christine L. Sun, Shawn Sullivan, Gherman Uritskiy, Timothy P L Smith, Derek M. Bickhart, Matthew B. Sullivan, Ahmed A. Zayed, Andrew H. Wiser, Huerta Gd, Maximilian O. Press, Stephen M. Eacker, Grove J

Viruses play crucial roles in the ecology of microbial communities, yet they remain relatively understudied in their native environments. Despite many advancements in high-throughput whole-genome sequencing (WGS), sequence assembly, and annotation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::156b5aff78463cfd65822b8473fcc10d
https://doi.org/10.1101/2021.06.14.448389

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Genome sequence of Monilinia vaccinii-corymbosi sheds light on mummy berry disease infection of blueberry and mating type

Autor: Ivan Liachko, Marc A. Cubeta, Stephen M. Eacker, Shawn Sullivan, Kamaldeep Bansal, Jeffrey A. Rollins, Ashley G Yow, Hamid Ashrafi, Yucheng Zhang

Publikováno v: G3: Genes|Genomes|Genetics

Mummy berry disease, caused by the fungal pathogen Monilinia vaccinii-corymbosi (Mvc), is one of the most economically important diseases of blueberries in North America. Mvc is capable of inducing two separate blighting stages during its life cycle.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82183289b763e1b099bf0a927a34858
https://pubmed.ncbi.nlm.nih.gov/33598705

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Advancing the genetic utility of pre-clinical species through a high-quality assembly of the cynomolgus monkey (Macaca fascicularis) genome

Autor: Elias M. Oziolor, Michael J. Agostino, Stephen M. Eacker, Petra H. Koza-Taylor, Laurence O. Whiteley, Jon C. Cook, Hayley Mangelson, Shawn Sullivan

The cynomolgus macaque is a non-human primate model, heavily used in biomedical research, but with outdated genomic resources. Here we have used the latest long-read sequencing technologies in order to assemble a fully phased, chromosome-level assemb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc372c04c3de930d3e258cd774b1b369

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Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis

Autor: Li Chen, D. James Surmeier, Stephen M. Eacker, Jinchong Xu, Jungwoo Wren Kim, Ian Martin, Tamara Perez-Rosello, Mohammed Repon Khan, Zhong Xie, Leire Abalde-Atristain, Manoj Kumar, Nicholas T. Ingolia, Aanishaa Jhaldiyal, Xiling Yin, Ted M. Dawson, Valina L. Dawson

Publikováno v: Cell Stem Cell

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson’s disease (PD). This mutation results in dopaminergic neurodegeneration via dysregulated protein translation, although how alterations in protein sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33796b7cfa65c0abb3f0f95069f5cd06
https://pubmed.ncbi.nlm.nih.gov/32846140

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