Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Stephen M Beverley"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010893 (2022)
Immediately following their deposition into the mammalian host by an infected sand fly vector, Leishmania parasites encounter and are engulfed by a variety of cell types. From there, parasites may transit to other cell types, primarily macrophages or
Externí odkaz:
https://doaj.org/article/e1817d4d87674be0b5a9e2eb661b3d3b
Autor:
Jyoti Pant, Marie Samanovic, Maria T Nelson, Mert K Keceli, Joseph Verdi, Stephen M Beverley, Jayne Raper
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1008768 (2021)
Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective
Externí odkaz:
https://doaj.org/article/3122d2551537448dafd74d30109fbcd5
Autor:
Marta Reverte, Remzi Onur Eren, Baijayanti Jha, Chantal Desponds, Tiia Snäkä, Florence Prevel, Nathalie Isorce, Lon-Fye Lye, Katherine L Owens, Ulisses Gazos Lopes, Stephen M Beverley, Nicolas Fasel
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009422 (2021)
The oxidative burst generated by the host immune system can restrict intracellular parasite entry and growth. While this burst leads to the induction of antioxidative enzymes, the molecular mechanisms and the consequences of this counter-response on
Externí odkaz:
https://doaj.org/article/0afbb9684d2240dd949e1accd28bc3af
Autor:
John N Filosa, Corbett T Berry, Gordon Ruthel, Stephen M Beverley, Wesley C Warren, Chad Tomlinson, Peter J Myler, Elizabeth A Dudkin, Megan L Povelones, Michael Povelones
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007570 (2019)
Kinetoplastids are a group of parasites that includes several medically-important species. These human-infective species are transmitted by insect vectors in which the parasites undergo specific developmental transformations. For each species, this i
Externí odkaz:
https://doaj.org/article/871ed845e9de48afba906c5438aa2e02
Autor:
Ehud Inbar, Jahangheer Shaik, Stefano A Iantorno, Audrey Romano, Chukwunonso O Nzelu, Katherine Owens, Mandy J Sanders, Deborah Dobson, James A Cotton, Michael E Grigg, Stephen M Beverley, David Sacks
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008042 (2019)
Hybrid genotypes have been repeatedly described among natural isolates of Leishmania, and the recovery of experimental hybrids from sand flies co-infected with different strains or species of Leishmania has formally demonstrated that members of the g
Externí odkaz:
https://doaj.org/article/b6ea26ffaa1840df8e10f7653d4d759f
Autor:
Bennett J Davenport, Casey G Martin, Stephen M Beverley, David J Orlicky, Andres Vazquez-Torres, Thomas E Morrison
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006921 (2018)
Leishmania species are sand fly-transmitted protozoan parasites that cause leishmaniasis, neglected tropical diseases that affect millions of people. Leishmania amastigotes must overcome a variety of host defenses, including reactive oxygen species (
Externí odkaz:
https://doaj.org/article/ac0e9b0003914442986e96da9f3d93e1
Autor:
Patrik Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T Utzschneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F Matthew Kuhlmann, Stephen M Beverley, Nicolas Fasel, Catherine Ronet
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005240 (2017)
Recent studies have shown that a cytoplasmic virus called Leishmaniavirus (LRV) is present in some Leishmania species and acts as a potent innate immunogen, aggravating lesional inflammation and development in mice. In humans, the presence of LRV in
Externí odkaz:
https://doaj.org/article/814482f6e64048e3ade8058ed03f86cf
Autor:
Luiz Henrique Guimarães, Adriano Queiroz, Juliana A Silva, Silvana C Silva, Viviane Magalhães, Ednaldo L Lago, Paulo Roberto L Machado, Olívia Bacellar, Mary E Wilson, Stephen M Beverley, Edgar M Carvalho, Albert Schriefer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005100 (2016)
BACKGROUND:Atypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL.
Externí odkaz:
https://doaj.org/article/edb623f9e0cb40238c7c7f0aa7d84b76
Autor:
Olivia C. Ihedioha, Haley Q. Marcarian, Anutr Sivakoses, Stephen M. Beverley, Diane McMahon-Pratt, Alfred L. M. Bothwell
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundHost-related factors highly regulate the increased circulation of neutrophils during Leishmania infection. Platelet-derived Dickkopf-1 (DKK1) is established as a high-affinity ligand to LRP6. Recently, we demonstrated that DKK1 upregulates
Externí odkaz:
https://doaj.org/article/55f928ce26a24a75b624a2873a7d0b5d
Autor:
Mary-Anne Hartley, Eliane Bourreau, Matteo Rossi, Patrik Castiglioni, Remzi Onur Eren, Florence Prevel, Pierre Couppié, Suzanne M Hickerson, Pascal Launois, Stephen M Beverley, Catherine Ronet, Nicolas Fasel
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005852 (2016)
Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened papules to extensive open ulcerations that metastasise to secondary sites and are often resistant to standard therapies. In the case of L. guyanensis (L.g), about 5-10%
Externí odkaz:
https://doaj.org/article/0a44ffda5fb54cbb8624a4f7be6a9e16