Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephen M, Prouty"'
Autor:
Jianhe Huang, Satish Sati, Christina Murphy, Casey A. Spencer, Emmanuel Rapp, Stephen M. Prouty, Scott Korte, Olivia Ahart, Emily Sheng, Parker Jones, Anna E. Kersh, Denis Leung, Thomas H. Leung
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114742- (2024)
Summary: Mammals typically heal with fibrotic scars, and treatments to regenerate human skin and hair without a scar remain elusive. We discovered that mice lacking C-X-C motif chemokine receptor 2 (CXCR2 knockout [KO]) displayed robust and complete
Externí odkaz:
https://doaj.org/article/842d739eea944b0ea61fb1e5adb5059f
Autor:
Pamela J. Hornby, Bruce P. Damiano, Alexey B. Dyatkin, N. H. Wallace, M. Carolyn Fisher, Stephen M. Prouty, Bruce E. Maryanoff, Edward S. Kimball, Wei He, Rosemary J. Santulli, Craig R. Schneider, Yong Gong, William A. Kinney, Craig J. Diamond, Tamara A. Miskowski
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6693-6702
A series of N-carboxy, N-alkyl, and N-carboxamido azabicyclo[2.2.2]octane carboxamides were prepared and assayed for inhibition of α4β1-VCAM-1 and α4β7-MAdCAM-1 interactions. Potency and α4β1/α4β7 selectivity were sensitive to the substituent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fac0ca403e4acd6788a9ee123e776a
https://doi.org/10.1016/j.bmc.2005.07.022
https://doi.org/10.1016/j.bmc.2005.07.022
Publikováno v:
Biochemical and Biophysical Research Communications. 327:64-69
Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an appare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac554fa2a6a577d9eb39e65c25c02c3
https://doi.org/10.1016/j.bbrc.2004.11.136
https://doi.org/10.1016/j.bbrc.2004.11.136
Autor:
Stephen M. Prouty, Pamela J. Hornby
Publikováno v:
British Journal of Pharmacology. 141:1335-1345
From a historical perspective to the present day, all the evidence suggests that activation of cannabinoid receptors (CBRs) is beneficial for gut discomfort and pain, which are symptoms related to dysmotility and visceral perception. CBRs comprise G-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c33bb2e8fd4117d9d2e93fdc6121e6
https://doi.org/10.1038/sj.bjp.0705783
https://doi.org/10.1038/sj.bjp.0705783
Autor:
Dennis J. Hlasta, Stephen M. Prouty, Wei He, Bruce P. Damiano, William J. Hoekstra, Pamela J. Hornby, M. Carolyn Fisher, William A. Kinney, Patricia Andrade-Gordon, Alexey B. Dyatkin, William M. Abraham, Edward S. Kimball, Maria Kontoyianni, Bruce E. Maryanoff, Rosemary J. Santulli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:591-596
The design, synthesis, and biological activity of novel α 4 β 1 and α 4 β 7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479b6bb212e629c9276b9ca2655baca7
https://doi.org/10.1016/j.bmcl.2003.11.063
https://doi.org/10.1016/j.bmcl.2003.11.063
Publikováno v:
Journal of Cutaneous Pathology. 29:268-278
Background: An animal model for the study of basal cell carcinoma (BCC) is required to better understand its biology. Several attempts to grow BCC in immuno-incompetent animals have been only modestly successful. Methods: To test the ability of BCC t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033fa9ec5cbe217af7df05b64ac550fa
https://doi.org/10.1034/j.1600-0560.2002.290502.x
https://doi.org/10.1034/j.1600-0560.2002.290502.x
Autor:
Stephen M. Prouty, Roshantha A.S. Chandraratna, William Samuel, Barbara Wiggert, Joel S. Gordon, R. Krishnan Kutty, Sahrudaya Nagineni
Publikováno v:
Journal of Biological Chemistry. 276:28744-28750
Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of the monounsaturated fatty acids palmitoleate and oleate. The regulation of SCD is of physiological importance because the ratio of saturated fatty acids to unsaturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7915ca55c23864fafed66b6ba81dae
https://doi.org/10.1074/jbc.m103587200
https://doi.org/10.1074/jbc.m103587200
Publikováno v:
Biochemical Journal. 357:183-193
Stearoyl-CoA desaturase is the rate-limiting enzyme in the production of mono-unsaturated fatty acids. We have recently cloned and characterized the human Scd cDNA and SCD (the stearoyl-CoA desaturase structural gene) on chromosome 10, as well as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a308c71ef0a0eef3ef8343ae1a8ed9a6
https://doi.org/10.1042/bj3570183
https://doi.org/10.1042/bj3570183
Autor:
John P. Sundberg, Stephen M. Prouty, Ying Zheng, Satish Parimoo, Kurt S. Stenn, Alex M. Harmon
Publikováno v:
Genomics. 71:182-191
Stearoyl-coenzyme A (CoA) desaturase (SCD) is a key enzyme involved in the conversion of saturated fatty acids into monounsaturated fatty acids. Previously, two members of this gene family, namely, Scd1 and Scd2, have been reported. Here we report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c57b989fed4fc14cc882efdb5a9f4f
https://doi.org/10.1006/geno.2000.6429
https://doi.org/10.1006/geno.2000.6429
Publikováno v:
Biochemical Journal. 340:255-264
A critical step in the synthesis of unsaturated fatty acids is catalysed by stearoyl-CoA desaturase (Scd). To determine the regulation of human Scd, we characterized the gene and its transcripts. Screening a human keratinocyte cDNA library and analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b13c0ef468539b93299c526f4ce211c
https://doi.org/10.1042/bj3400255
https://doi.org/10.1042/bj3400255