Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stephen M, Harrison"'
Autor:
Sheena Trigg, Jason M. Wells, Jasmine McGann, Soeren Bock, Adam Holman, Stephen M. Harrison, Ching Yong Goh, Stephen A. Moggach, David H. Brown
Publikováno v:
Drug Testing and Analysis. 14:1672-1680
Autor:
Joelle Le, Sharon Butler, James E. Rowedder, Stephen M. Harrison, John Martin Pritchard, Anderson Niall Andrew, Claire E. Smith, Rosemary Maghames, Simon J. F. Macdonald, Aleix Pastor-Garcia, Sebastien Andre Campos, Giovanni Vitulli, Jack Thomas, Royston C. B. Copley, Ian B. Duncan
Publikováno v:
Journal of medicinal chemistry. 62(19)
The heterodimeric transmembrane αv integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmonary fibrosis. Herein, we describe how subtle modifications of the central aromatic ring of a series of phenylbutyr
Autor:
Jill C. Richardson, James I. Elliott, Frederick W.K. Tam, Stephen Taylor, Charles D. Pusey, Dorothy K. Sojka, Steven A. Sheardown, Mireya Gonzalez-Begne, Stephen M. Harrison
Publikováno v:
Journal of Leukocyte Biology. 85:978-986
The purinergic receptor P2X7 is expressed on immune cells, and its stimulation results in the release of IL-1β from macrophages. Its absence, as evidenced from the analysis of two independent strains of P2X7-deficient mice, results in reduced suscep
Autor:
Stephen A. Douglas, Charlene Wu, K D Hoffman, Michael J. Neeb, R R Hernandez, Stephen M. Harrison, Eliot H. Ohlstein, Jason W. Dodson, John J. McAtee, Nambi Aiyar, Harvey E. Fries, David J. Behm, J M Lai, Christopher A. Evans
Publikováno v:
British Journal of Pharmacology. 155:374-386
Background and purpose: The recent development of the UT ligand palosuran (1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl- quinolin-4-yl)-urea sulphate salt) has led to the proposition that urotensin-II (U-II) plays a significant patholo
Autor:
A. J. Hunter, Jane E. Cluderay, J. Latcham, Christian Heidbreder, Pippa L Pugh, Jon T. Brown, Charlie Reavill, Lee A. Dawson, Ceri H. Davies, Evelyn Grau, Susan J. Pickering, G Brown, Claire S. Shilliam, Barry Crook, A Howarth, Panida Hemmati, Zoe A. Hughes, Derek C. Rogers, Guillaume J. Hervieu, Stephen M. Harrison, Peter R. Maycox
Publikováno v:
Molecular and Cellular Neuroscience. 24:1170-1179
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA1 is a Gi-coupled seven transmembrane r
Autor:
Stephen M. Harrison, Kristeen Maniscalco, David J. Behm, Zhaohui Ao, Robert N. Willette, Susan J. Pickering, Stephen A. Douglas, Evelyn Grau, Robert W. Coatney, Douglas G. Johns, Christopher P. Doe, Tina N Woods
Publikováno v:
British Journal of Pharmacology. 139:464-472
1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. Currently, only one mouse U-II receptor (UT) gene has been cloned. It is postulated that this protein
Autor:
Nambi Aiyar, Beverly E. Maleeff, Usman Shabon, Diane Naselsky, Zhaohui Ao, Stephen M. Harrison, Jyoti Disa, Stephen A. Douglas, Graham Duddy, Nabil Elshourbagy, Jan L. Sechler
Publikováno v:
British Journal of Pharmacology. 136:9-22
Urotensin-II (U-II) and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases. To test such hypothesis, it will be necessary to develop experimental animal models for the manipulation of U-II/UT
Autor:
Robert S. Kiss, Eliot H. Ohlstein, Zhipeng You, Anthony O. Gramolini, David J. Behm, Wisam Al-Ramli, Pedro D'Orléans-Juste, Salman T. Qureshi, Stephen A. Douglas, Nicolas Bousette, Stephen M. Harrison, Adel Giaid, Jacques Genest
Publikováno v:
Circulation research. 105(7)
Rationale : Expression of the vasoactive peptide Urotensin II (UII) is elevated in a number of cardiovascular diseases. Objective : Here, we sought to determine the effect of UII receptor (UT) gene deletion in a mouse model of atherosclerosis. Method
Autor:
Zhipeng You, Nicolas Bousette, Stephen M. Harrison, Eliot H. Ohlstein, David J. Behm, Wisam Al-Ramli, Adel Giaid, Panayiota Papadopoulos, Stephen A. Douglas
Publikováno v:
Atherosclerosis. 204(2)
Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. However, their exact role in atherosclerosis remains to be determined. In the present study we used four
Autor:
David J, Behm, Stephen M, Harrison, Zhaohui, Ao, Kristeen, Maniscalco, Susan J, Pickering, Evelyn V, Grau, Tina N, Woods, Robert W, Coatney, Christopher P A, Doe, Robert N, Willette, Douglas G, Johns, Stephen A, Douglas
Publikováno v:
British journal of pharmacology. 139(2)
1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. Currently, only one mouse U-II receptor (UT) gene has been cloned. It is postulated that this protein