Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Autor: Jo Fen Liu, Timothy R. Rebbeck, Brian E. Henderson, Vincent Khoo, Lynne T. O'Brien, Anna M. Ray, Klara Stefflova, Ethan M. Lange, Joanne L. Dickinson, Shannon K. McDonnell, Sarah J Lewis, Amit Joshi, Thilo Dörk, Jyotsna Batra, Yong-Jie Lu, Manuel Luedeke, Rosemary A. Wilkinson, Michelle Guy, C. R. J. Woodhouse, David E. Neal, Christopher A. Haiman, Gianluca Severi, Liesel M. FitzGerald, Audrey Ardern-Jones, Douglas F. Easton, Erika M. Kwon, Colin Cooper, Dallas R. English, Kathleen A. Cooney, Daniel Leongamornlert, Graham G. Giles, Loic Le Marchand, Laurence N. Kolonel, C. Slavov, Daniel J. Schaid, Ahva Shahabi, Suzanne K. Chambers, Teuvo L.J. Tammela, Jong Y. Park, Johanna Schleutker, Robert Huddart, Melissa C. Southey, Sue A. Ingles, Tim Christmas, Judith A. Clements, Mary-Anne Kedda, Malgorzata Tymrakiewicz, David P. Dearnaley, Radka Kaneva, Edward J. Saunders, Thomas A. Sellers, Janet L. Stanford, Anssi Auvinen, Alan Thompson, Jonathan J. Morrison, Guangwen Cao, Amanda L. Hall, Humera Khan, Pierre Hutter, Stephen M. Edwards, Esther M. John, Emma J. Sawyer, Angela Cox, Lisa A. Cannon-Albright, Tiina Wahlfors, Pierre O. Chappuis, Stephen N. Thibodeau, Freddie C. Hamdy, Elaine A. Ostrander, Hong Wei Zhang, Nicholas Van As, John L. Hopper, Walther Vogel, Amanda B. Spurdle, Jürgen Serth, Joanne F. Aitken, Chris Ogden, Atanaska Mitkova, Felicity Lose, Zsofia Kote-Jarai, Elizabeth Page, Christiane Maier, Joseph S. Koopmeiners, William D. Foulkes, Kenneth Muir, Alan Horwich, Danielle M. Karyadi, Chris Parker, Briony Patterson, Julio M. Pow-Sang, Robert A. Gardiner, Ali Amin Al Olama, Mariana C. Stern, Roman Corral, Maurice P. Zeegers, Andrea M. Polanowski, Artitaya Lophatananon, Rosalind A. Eeles, Andreas Meyer, J. M. Farnham, Jenny L Donovan

Publikováno v: Nature Genetics, 41(10), 1116-21. Nature Publishing Group

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bba7ec862958c7310199b40974e05bb
https://cris.maastrichtuniversity.nl/en/publications/07d789de-e322-4232-8a52-f7381f8c3cc1

Macrophage Scavenger Receptor 1 999C>T (R293X) Mutation and Risk of Prostate Cancer

Autor: Douglas F. Easton, Kenneth Muir, Gianluca Severi, Sarah Bullock, Ketil Heimdal, Richard S. Houlston, William D. Foulkes, Questa Hope, David P. Dearnaley, Lovise Maehle, Stephen M. Edwards, Sameer Jhavar, David Roquis, James C. Engert, Christine Southgate, Daniel Sinnett, Nancy Hamel, Michael D. Badzioch, Jacques Simard, Melissa C. Southey, Alison Falconer, A Dowe, Graham G. Giles, John L. Hopper, Christopher H. Evans, Pål Møller, Rosalind A. Eeles, Dallas R. English, Julia C. Meitz

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 14:397-402

Background: Variants in the gene encoding the macrophage scavenger receptor 1 (MSR14) protein have been identified in men with prostate cancer, and several small studies have suggested that the 999C>T (R293X) protein-truncating mutation may be associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786c83fb683a29c19060457339042e4e
https://doi.org/10.1158/1055-9965.epi-04-0202

ATM polymorphisms as risk factors for prostate cancer development

Autor: Brigitte Chapot, Norman Moullan, Audrey Ardern-Jones, Sandra Angèle, A. R. Norman, Richard S. Houlston, David P. Dearnaley, Christine Southgate, Michael Bremer, S Bullock, Stephen M. Edwards, Julia C. Meitz, Q Hope, A Dowe, Janet Hall, Thilo Dörk, Kenneth Muir, Rosalind A. Eeles, Doug Easton, A Falconer

Publikováno v: British Journal of Cancer
Europe PubMed Central
Scopus-Elsevier

The risk of prostate cancer is known to be elevated in carriers of germline mutations in BRCA2, and possibly also in carriers of BRCA1 and CHEK2 mutations. These genes are components of the ATM-dependent DNA damage signalling pathways. To evaluate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46da5581b38a5fc84de83c2ca4b0dd4b
http://europepmc.org/articles/PMC2364767

HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease

Autor: Stephen M. Edwards, S Williams, R A Jackson, Audrey Ardern-Jones, Michael R. Stratton, Julia C. Meitz, A Murkin, Doug Easton, Richard S. Houlston, David P. Dearnaley, Rosalind A. Eeles

Publikováno v: British Journal of Cancer

The candidate prostate cancer susceptibility gene HPC2/ELAC2 has two common coding polymorphisms: (Ser→Leu 217) and (Ala→Thr 541). The Thr541 variant in the HPC2/ELAC2 gene has previously been reported to be at an increased frequency in prostate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad5fcd33da5473e82b80462bb74d58f
http://europepmc.org/articles/PMC2376179

BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

Autor: J Broni, Peter Osin, Gyula Kovacs, S Gill, Martin J. S. Dyer, Rosalind A. Eeles, Tony G. Willis, Norman J. Maitland, Stephen M. Edwards, S Jefferies, Colin Cooper

Publikováno v: British Journal of Cancer. 80:1565-1568

We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbefc2c53f3767ddee7a8c12ecfcd5de
https://doi.org/10.1038/sj.bjc.6690561