Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Stephen L. Madden"'
Using single nuclear RNAseq to assess impact of AAV-ARSA gene therapy on oligodendrocyte populations
Autor:
Yinyin Huang, Shyam Ramachandran, Swathi Ayloo, Jeffery Ardinger, Dongyu Liu, Joseph Gans, Stephen L. Madden, Giorgio Gaglia, Erin Teeple, Nima Nouri, Martin Goulet, Christian Mueller, Virginia Savova
Publikováno v:
Molecular Genetics and Metabolism. 138:107156
Autor:
Bing Wang, Mandy M. Smith, Stefano Zanotti, Stephen L. Madden, Hervé Husson, Vijay Modur, Laurie A. Smith, Nikolay O. Bukanov, Thomas A. Natoli, Sarah Moreno, Tyler Picariello, Katherine W. Klinger, Brenda Richards, Hyejung Park, Cheng Zhu, Oxana Ibraghimov-Beskrovnaya, Ryan J. Russo
Publikováno v:
Human Molecular Genetics
Bardet–Biedl syndrome (BBS) is a pleiotropic autosomal recessive ciliopathy affecting multiple organs. The development of potential disease-modifying therapy for BBS will require concurrent targeting of multi-systemic manifestations. Here, we show
Autor:
Deepak Rajpal, Stephen L. Madden, Joshi P, Klinger Kw, Pande Rs, Sardi Sp, Angel Cedazo-Minguez, Erin Teeple, Amilcar Flores-Morales, Dinesh Kumar, Latta Mahieu M, Huang Y
Understanding disease biology at a cellular level from disease specific tissues is imperative for effective drug development for complex neurodegenerative diseases. We profiled 87,086 nuclei from putamen tissue of healthy controls, Parkinson’s Dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07d078e36ab2d2e50d971fd081149c1f
https://doi.org/10.1101/2021.05.06.442950
https://doi.org/10.1101/2021.05.06.442950
Autor:
Klinger Kw, Joshi P, Amilcar Flores-Morales, Dinesh Kumar, Angel Cedazo-Minguez, Sardi P, Deepak Rajpal, Stephen L. Madden, Pande Rs, Erin Teeple, Huang Y, Karambe A, Latta-Mahieu M
The role of oligodendrocytes in neurodegenerative diseases remains incompletely understood and largely unexplored at the single cell level. We profiled 87,086 single nuclei from human brain putamen region for healthy control, Parkinson’s Disease (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf6249bf3d4f9795c445956ca1466f72
https://doi.org/10.1101/2021.05.06.442967
https://doi.org/10.1101/2021.05.06.442967
Autor:
Yingnan Han, Stephen L. Madden, Katherine W. Klinger, Dongyu Liu, Cheng Zhu, Erin Teeple, Francesca Frau, Srinivas Shankara, Deepak Rajpal, S. Pablo Sardi, Mahdiar Sadeghi, Clarence Wang, Dinesh Kumar, FinnGen
SUMMARYParkinson’s Disease (PD) is the second most common and fastest-growing neurological disorder. Polygenic Risk Scores (PRS) using hundreds to thousands of PD-associated variants support polygenic heritability. Here, for the first time, we appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8db62596a9ef5161243d0e2b239629
https://doi.org/10.1101/2020.10.16.20212944
https://doi.org/10.1101/2020.10.16.20212944
Autor:
Srinivas Shankara, Stephen L. Madden, Erin Teeple, Khushboo Jindal, S. Pablo Sardi, Beril Kiragasi, Can Kayatekin, Siddharth Annaldasula, Dinesh Kumar, Ann Byrne, Klinger Kw, Lilly Chai, Mahdiar Sadeghi
Alpha-synuclein (SNCA) aggregates are pathological hallmarks of synucleinopathies, neurodegenerative disorders including Parkinson’s Disease (PD) and Lewy Body Dementia (LBD). Functional networks are not yet well-characterized for SNCA by CNS cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41970ad3c85a1d7016b02ad3fe246330
https://doi.org/10.1101/2020.06.05.137166
https://doi.org/10.1101/2020.06.05.137166
Autor:
Paul Mason, Beirong Liang, Lingyun Li, Trisha Fremgen, Erin Murphy, Angela Quinn, Stephen L Madden, Hans-Peter Biemann, Bing Wang, Aharon Cohen, Svetlana Komarnitsky, Kate Jancsics, Brad Hirth, Christopher G F Cooper, Edward Lee, Sean Wilson, Roy Krumbholz, Steven Schmid, Yibin Xiang, Michael Booker, James Lillie, Kara Carter
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33823 (2012)
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion o
Externí odkaz:
https://doaj.org/article/ca2a1923edbd4b9b8ad45765ca768d84
Autor:
Siem de Marie, A. Hasegawa, Alison McVie-Wylie, Rachel Palmer, Patrick Finn, Robert J. Pomponio, Mario Pescatori, K. So, K.M. Ciociola, Adam Palermo, Sueli Mieko Oba-Shinjo, Robert J. Mattaliano, Shruti Madhiwalla, Brenda Richards, Katherine W. Klinger, Stephen L. Madden, Mindy Zhang
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Pompe disease is a genetic disorder resulting from a deficiency of lysosomal acid alpha-glucosidase (GAA) that manifests as a clinical spectrum with regard to symptom severity and rate of progression. In this study, we used microarrays to examine gen
Autor:
Stephen L. Madden, E. Anders Kolb, Peter J. Houghton, Min H. Kang, Stephen T. Keir, Christopher L. Morton, Beverly A. Teicher, Richard B. Lock, John M. Maris, Hernan Carol, Catherine A. Billups, C. Patrick Reynolds, Mindy Zhang, Malcolm A. Smith, Richard Gorlick
Publikováno v:
Pediatric Blood & Cancer. 58:200-209
Background Genz-644282 is a novel non-camptothecin topoisomerase I poison that is in clinical development. Procedures Genz-644282 was tested against the PPTP in vitro panel (0.1 nM to 1 µM), and in vivo using three times per week × 2 schedule repea
Autor:
Charlene Manning, Fangxian Sun, Stephen L. Madden, Sherry Cao, Hongjing Qu, Richard C. Gregory, Robert J. Pomponio, Michele Sanicola-Nadel, Dmitri Wiederschain, Natalia Malkova, Gary Shapiro, Jean Cavallo, Christopher Winter, Tun Tun Lin, Joachim Theilhaber, Parminder Mankoo, Jack Pollard
Publikováno v:
Cancer Research. 78:5550-5550
TGFβ is a potent immunosuppressive cytokine, acting on multiple cell types of both the innate and adaptive immune systems. Emerging preclinical and clinical data implicate TGFβ in tumor immune evasion, poor prognosis and resistance to PD1/PDL1 dire