Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stephen L. Lake"'
Autor:
Kristine Broglio, Stephen L. Lake, Melanie Quintana, Jennifer Panagoulias, Michael Panzara, Scott M. Berry
Publikováno v:
Statistics in Medicine. 40:4167-4184
A Bayesian adaptive design is proposed for a clinical trial in Duchenne muscular dystrophy. The trial was designed to demonstrate treatment efficacy on an ambulatory-based clinical endpoint and to identify early success on a biomarker (dystrophin pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b609f1f44a0aadc52e72717803e807
https://doi.org/10.1002/sim.9021
https://doi.org/10.1002/sim.9021
Publikováno v:
Pharmaceutical Statistics. 19:315-325
The design of a clinical trial is often complicated by the multi-systemic nature of the disease; a single endpoint often cannot capture the spectrum of potential therapeutic benefits. Multi-domain outcomes which take into account patient heterogeneit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc397a6d3ac902caee37d840f8b7c2c0
https://doi.org/10.1002/pst.1993
https://doi.org/10.1002/pst.1993
Autor:
Juan C. Celedón, Kelan G. Tantisira, Amy Murphy, Lydiana Avila, Barbara J. Klanderman, Scott T. Weiss, Stephen L. Lake, Manuel E. Soto-Quiros
Publikováno v:
The American Journal of Human Genetics. 85(1):87-96
Asthma incidence and prevalence are higher in obese individuals. A potential mechanistic basis for this relationship is pleiotropy. We hypothesized that significant linkage and candidate-gene association would be found for body mass index (BMI) in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf81baa1a2b3f0e605bb581b586b829
Autor:
Nelson B. Freimer, Catherine Liang, Edwin K. Silverman, Lydiana Avila, Amy Murphy, Thomas J. Hudson, Benjamin A. Raby, Manuel E. Soto-Quiros, Jody S. Sylvia, Mitzi Spesny, Andrei Verner, Juan C. Celedón, Stephen L. Lake, Barbara J. Klanderman, Eduardo Fournier
Publikováno v:
Human Molecular Genetics. 16:243-253
Serum total immunoglobulin E (IgE) is a critical intermediate phenotype of allergic diseases. Although total IgE exhibits sexual dimorphism in humans (with males demonstrating higher IgE than females), the molecular basis of this difference is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9e14396ae108ec82fa057d99af0be5
https://doi.org/10.1093/hmg/ddl447
https://doi.org/10.1093/hmg/ddl447
Autor:
Sorachai Srisuma, Scott T. Weiss, Edwin K. Silverman, Stephen L. Lake, Steven D. Shapiro, David Sparrow, Thomas J. Mariani, Victor Pinto-Plata, Brigham H. Mecham, Frank E. Speizer, Augusto A. Litonjua, Jody S. Sylvia, Christoph Lange, Dawn L. DeMeo, Avrum Spira, Harold A. Chapman, Juan C. Celedón, Kathleen J. Haley, John J. Reilly, Jennifer Beane
Publikováno v:
The American Journal of Human Genetics. 78:253-264
Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe alpha 1-antitrypsin deficiency is a proven genetic risk factor for COPD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc655c3221d77dd2a44877e713b20cc3
https://doi.org/10.1086/499828
https://doi.org/10.1086/499828
Autor:
Christine T. Finn, Stephen L. Lake, Pamela DeRosse, Alex M. Plocik, Birgit Funke, Raju Kucherlapati, John M. Kane, Anil K. Malhotra
Publikováno v:
The American Journal of Human Genetics. 75(5):891-898
Linkage and association studies have recently implicated dystrobrevin-binding protein 1 (DTNBP1) in the etiology of schizophrenia. We analyzed seven previously tested DTNBP1 single-nucleotide polymorphisms (SNPs) in a cohort of 524 individuals with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80934baa7e6ec97aed8da9250c01bd2
Autor:
Stephan Heckers, Carol Routledge, John Brown, Marilyn S. Albert, Reisa A. Sperling, Stephen L. Lake, Nicholas Lange
Publikováno v:
Statistics in Medicine. 23:327-350
Among the many diseases that affect the hippocampus, a small yet highly important brain region responsible for memory and identity, Alzheimer's disease and schizophrenia are among the most devastating. We describe a two-stage, region-of-interest base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121df351873dff987cad87a64ce58934
https://doi.org/10.1002/sim.1720
https://doi.org/10.1002/sim.1720
Autor:
Ross Lazarus, Stephen L. Lake, Adrienne G. Randolph, Christoph Lange, Benjamin A. Raby, Scott T. Weiss, Helen Lyon, Nan M. Laird, David J. Kwiatkowski, Edwin K. Silverman, Katy M. Weiland
Publikováno v:
Genetic Epidemiology. 26:155-165
IL10 is an anti-inflammatory cytokine that has been found to have lower production in macrophages and mononuclear cells from asthmatics. Since reduced IL10 levels may influence the severity of asthma phenotypes, we examined IL10 single-nucleotide pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93abd1636af6ee11643ce543f1dd16eb
https://doi.org/10.1002/gepi.10298
https://doi.org/10.1002/gepi.10298
Autor:
Nan M. Laird, Stephen L. Lake
Publikováno v:
Annals of Human Genetics. 68:55-64
As knowledge of the human genome continues to grow, more progress is being made towards not only identifying the genes involved in disease susceptibility but also in defining the synergistic role genes play with environmental exposures. The detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c951a61a24776494e10d3dbb865f2f
https://doi.org/10.1046/j.1529-8817.2003.00073.x
https://doi.org/10.1046/j.1529-8817.2003.00073.x
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 19:377-384
We previously reported that insulin accumulated in the retina and optic nerve following ocular application. Since the optic nerve is surrounded by meninges and cerebrospinal fluid (CSF) and since it extends back to the thalamus, we examined whether t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c141411863c88467c1e7933bd3bb50d7
https://doi.org/10.1089/108076803322279435
https://doi.org/10.1089/108076803322279435