Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is a Bimodal Process

Autor: Paige Garrison, Umaer Khan, Michael Cipriano, Peter J. Bush, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Terry K. Smith, Stephen L. Hajduk, James D. Bangs

Publikováno v: mBio, Vol 12, Iss 4 (2021)

ABSTRACT African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific pho

Externí odkaz: https://doaj.org/article/bf9bd0020fb4404db69135c5e3a5c6f5

Lexis and grammar of mitochondrial RNA processing in Trypanosomes

Autor: Suzanne M. McDermott, Z. Hong Zhou, H. Ulrich Göringer, Alena Zíková, Kenneth Stuart, Igor Cestari, Reza Salavati, Stephen L. Hajduk, Julius Lukeš, Ruslan Aphasizhev, Dmitri A. Maslov, Jason Carnes, Achim Schnaufer, Inna Aphasizheva, Larry Simpson, Torsten Ochsenreiter, Jorge Cruz-Reyes, Laurie K. Read, André Schneider, Susan Madison-Antenucci, Vyacheslav Yurchenko, Liye Zhang, Juan D. Alfonzo, Sara L. Zimmer

Publikováno v: Aphasizheva, I, Alfonzo, J, Carnes, J, Cestari, I, Cruz-Reyes, J, Göringer, H U, Hajduk, S, Lukeš, J, Madison-Antenucci, S, Maslov, D A, McDermott, S M, Ochsenreiter, T, Read, L K, Salavati, R, Schnaufer, A, Schneider, A, Simpson, L, Stuart, K, Yurchenko, V, Zhou, Z H, Zíková, A, Zhang, L, Zimmer, S & Aphasizhev, R 2020, ' Lexis and grammar of mitochondrial RNA processing in Trypanosomes ', Trends in Parasitology, vol. 36, no. 4, pp. 337-355 . https://doi.org/10.1016/j.pt.2020.01.006
Trends in parasitology, vol 36, iss 4

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171b9f7520b2af84d845636eb4343d1
https://hdl.handle.net/20.500.11820/def562e4-fc49-427d-84a3-da811b3f009b

Alternative mRNA editing in trypanosomes is extensive and may contribute to mitochondrial protein diversity.

Autor: Torsten Ochsenreiter, Michael Cipriano, Stephen L Hajduk

Publikováno v: PLoS ONE, Vol 3, Iss 2, p e1566 (2008)

The editing of trypanosome mitochondrial mRNAs produces transcripts necessary for mitochondrial functions including electron transport and oxidative phosphorylation. Precursor-mRNAs are often extensively edited by specific uridine insertion or deleti

Externí odkaz: https://doaj.org/article/f2dbbf0e81684a06a02a1b9b64362e59

Drivers of persistent infection: pathogen-induced extracellular vesicles

Autor: Michael J. Cipriano, Stephen L. Hajduk

Publikováno v: Essays in biochemistry. 62(2)

Extracellular vesicles (EVs) are produced by invading pathogens and also by host cells in response to infection. The origin, composition, and function of EVs made during infection are diverse and provide effective vehicles for localized and broad dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e013cd46960ad9ea2f5d57b2e0284b1b
https://pubmed.ncbi.nlm.nih.gov/29666211

Sending a message: extracellular vesicles of pathogenic protozoan parasites

Autor: John M. Harrington, Anthony J. Szempruch, Lauren Dennison, Rudo Kieft, Stephen L. Hajduk

Publikováno v: Nature reviews. Microbiology. 14(11)

Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules through EVs, pathogenic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a073002f9d00ff9adb9a2be12c2f124
https://pubmed.ncbi.nlm.nih.gov/27615028