Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Stephen L. Dodd"'
Autor:
Scott K. Powers, Stephen L. Dodd
For courses in Health and Fitness. Strengthen students'core knowledge of fitness and wellness Total Fitness and Wellness gives students a solid foundation in fitness and wellness, while providing them with the tools they need to make healthy behavior
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 144
Botulinum neurotoxin type A (BoNT/A) is used as a therapeutic tool to induce chemical denervation of spastically contracted muscles, yet the neurotoxin can also cause skeletal muscle atrophy. The underlying proteolytic mechanisms that induce this atr
Autor:
Scott K. Powers, Stephen L. Dodd
For Health and Fitness courses. Provide your students with interactive tools to succeed in fitness and wellness Total Fitness and Wellness gives students a solid foundation in fitness and wellness, while providing them with the tools they need to mak
Publikováno v:
American Journal of Physiology-Cell Physiology. 298:C38-C45
The purpose of the current study was to determine whether heat shock protein 70 (Hsp70) directly regulates forkhead box O (FOXO) signaling in skeletal muscle. This aim stems from previous work demonstrating that Hsp70 overexpression inhibits disuse-i
Publikováno v:
Muscle & Nerve. 41:110-113
We examined reactive oxygen species as upstream activators of nuclear factor kappaB; (NF-kappaB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasm
Publikováno v:
Toxicon. 52:455-464
To ensure safety and predictable clinical efficacy, the biological activity of type A botulinum toxin (BoNT-A) preparations must remain consistent. Several methods have been employed to assess consistency but lack clinical applicability and/or are as
Publikováno v:
Experimental Physiology. 93:479-485
We have previously shown oxidative stress and oedema, caused by both xanthine oxidase-derived oxidants and infiltrating neutrophils, within skeletal muscle after contractile-induced claudication. The purpose of this study was to determine whether sup
Autor:
Stephen L. Dodd, Ira J. Smith
Publikováno v:
Experimental Physiology. 92:561-573
The role of the calpain proteases in skeletal muscle atrophy is poorly understood. One goal of these experiments was to clarify whether calpains act upstream of the ubiquitin-proteasome pathway (UPP). Calpain activation may also inhibit the anabolic
Autor:
Roderic O'Keeffe, Fraser E. Houston, Kati L. Houston, Stephen L. Dodd, Thomas Adams, Brian A. Hain
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 119(1)
Botulinum neurotoxin type A (BoNT/A) is used clinically to induce therapeutic chemical denervation of spastically contracted skeletal muscles. However, BoNT/A administration can also cause atrophy. We sought to determine whether a major proteolytic p
Publikováno v:
Toxicon. 46:196-203
Botulinum neurotoxin type A has gained widespread use for treatment of a host of neuromuscular conditions. However, the potential effect of this toxin has on the histological and biochemical properties of skeletal muscle remains largely unexplored. T