Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Stephen L. Brown"'
Autor:
Sushmitha Sriramulu, Shivani Thoidingjam, Wei-Min Chen, Oudai Hassan, Farzan Siddiqui, Stephen L. Brown, Benjamin Movsas, Michael D. Green, Anthony J. Davis, Corey Speers, Eleanor Walker, Shyam Nyati
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel mole
Externí odkaz:
https://doaj.org/article/bec285331eba422bb5e204315df583c6
Autor:
Sushmitha Sriramulu, Shivani Thoidingjam, Farzan Siddiqui, Stephen L. Brown, Benjamin Movsas, Eleanor Walker, Shyam Nyati
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 625 (2024)
BUB1 is overexpressed in most human solid cancers, including breast cancer. Higher BUB1 levels are associated with a poor prognosis, especially in patients with triple-negative breast cancer (TNBC). Women with TNBC often develop resistance to chemoth
Externí odkaz:
https://doaj.org/article/3134a2ef6bee4cc8b1385d114f33931f
Autor:
Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Tavarekere N. Nagaraja, Benjamin Movsas, James R. Ewing, Indrin J. Chetty
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-23 (2023)
Abstract Here, we investigate radiomics-based characterization of tumor vascular and microenvironmental properties in an orthotopic rat brain tumor model measured using dynamic-contrast-enhanced (DCE) MRI. Thirty-two immune compromised-RNU rats impla
Externí odkaz:
https://doaj.org/article/423beb6312a542469a6b348ae770a43f
Autor:
Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Tavarekere N. Nagaraja, Olivia Grahm Valadie, Prabhu C. Acharya, Glauber Cabral, George Divine, Robert A. Knight, Ian Y. Lee, Jun H. Xu, Benjamin Movsas, Indrin J. Chetty, James R. Ewing
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract We introduce and validate four adaptive models (AMs) to perform a physiologically based Nested-Model-Selection (NMS) estimation of such microvascular parameters as forward volumetric transfer constant, Ktrans, plasma volume fraction, vp, and
Externí odkaz:
https://doaj.org/article/0ad2bbaeea014e0faf2ee47c285e3573
Autor:
Medha Munshi, Christine Slyne, Katie Weinger, Sarah Sy, Kayla Sifre, Amy Michals, Dai’Quann Davis, Rachel Dewar, Astrid Atakov-Castillo, Saira Haque, M. Stirling Cummings, Stephen L. Brown, Elena Toschi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Older adults with type 1 diabetes (T1D) have unique challenges and needs. In this mixed-methods study, we explored the impact of isolation during a pandemic on diabetes management and overall quality of life in this population. Older adults
Externí odkaz:
https://doaj.org/article/d8577c1256a74301b9ceb5253ca8ad3b
Autor:
Shivani Thoidingjam, Sushmitha Sriramulu, Svend Freytag, Stephen L. Brown, Jae Ho Kim, Indrin J. Chetty, Farzan Siddiqui, Benjamin Movsas, Shyam Nyati
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-21 (2023)
Abstract Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient’s cells to improve cancer therapy and
Externí odkaz:
https://doaj.org/article/94f8a2b05fb640139301d12e996dc08e
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life. Although cellular sene
Externí odkaz:
https://doaj.org/article/a52b235bb00b47aaa4ec039c9e7e7e95
Autor:
Stephen L. Brown, Peter L. Fisher, Andrew Morgan, Cari Davies, Yasmin Olabi, Laura Hope‐Stone, Heinrich Heimann, Rumana Hussain, Mary Gemma Cherry
Publikováno v:
Health Expectations, Vol 25, Iss 4, Pp 1498-1507 (2022)
Abstract Background Technological advances have led to cancer prognostication that is increasingly accurate but often unalterable. However, a reliable prognosis of limited life expectancy can cause psychological distress. People should carefully cons
Externí odkaz:
https://doaj.org/article/693b6478950741948fee9f150235deb8
Autor:
Sushmitha Sriramulu, Shivani Thoidingjam, Stephen L. Brown, Farzan Siddiqui, Benjamin Movsas, Shyam Nyati
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114126- (2023)
Radiotherapy is a standard cytotoxic therapy against solid cancers. It uses ionizing radiation to kill tumor cells through damage to DNA, either directly or indirectly. Radioresistance is often associated with dysregulated DNA damage repair processes
Externí odkaz:
https://doaj.org/article/d87ef8035fd44bdd8e94118b33fee42e
Autor:
Suneetha Devpura, PhD, Aharon M. Feldman, MD, Samuel D. Rusu, MSc, Essa Mayyas, PhD, Avielle Movsas, MD, Stephen L. Brown, PhD, Andrew Cook, MD, Michael J. Simoff, MD, Zhen Sun, MSc, Mei Lu, PhD, Sean Vance, MD, Munther I. Ajlouni, MD, M. Salim Siddiqui, MD, PhD, Indrin J. Chetty, PhD, Benjamin Movsas, MD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 6, Pp 100815- (2021)
Purpose: To analyze clinical toxicity and quality-of-life (QOL) outcomes among patients with stage I non-small cell lung cancer (NSCLC) after stereotactic body radiation therapy (SBRT) as a function of radiation dose and volume parameters. Methods an
Externí odkaz:
https://doaj.org/article/2b1f4c95832c4470898e15d321d774e0