Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Stephen L., Archer"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011832 (2023)
After entry into cells, herpes simplex virus (HSV) nucleocapsids dock at nuclear pore complexes (NPCs) through which viral genomes are released into the nucleoplasm where viral gene expression, genome replication, and early steps in virion assembly t
Externí odkaz:
https://doaj.org/article/45960e87cf284a1cb693b219b5d71c24
Autor:
Austin D. Read, Rachel E. T. Bentley, Ashley Y. Martin, Jeffrey D. Mewburn, Elahe Alizadeh, Danchen Wu, Patricia D. A. Lima, Kimberly J. Dunham‐Snary, Bernard Thébaud, Willard Sharp, Stephen L. Archer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background As partial pressure of oxygen (pO2) rises with the first breath, the ductus arteriosus (DA) constricts, diverting blood flow to the pulmonary circulation. The DA's O2 sensor resides within smooth muscle cells. The DA smooth muscle cells’
Externí odkaz:
https://doaj.org/article/e030b967cfd24d6397635a590b09f624
Autor:
Kevin Y. Chang, Katherine Giorgio, Katlin Schmitz, Rob F. Walker, Kurt W. Prins, Marc R. Pritzker, Stephen L. Archer, Pamela L. Lutsey, Thenappan Thenappan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 6 (2023)
Background Digoxin acutely increases cardiac output in patients with pulmonary arterial hypertension (PAH) and right ventricular failure; however, the effects of chronic digoxin use in PAH are unclear. Methods and Results Data from the Minnesota Pulm
Externí odkaz:
https://doaj.org/article/4b2a6de2a2c8424e9f5660eb229ddaee
Publikováno v:
Cells, Vol 12, Iss 21, p 2528 (2023)
DNA methylation is an epigenetic mechanism that regulates gene expression without altering gene sequences in health and disease. DNA methyltransferases (DNMTs) are enzymes responsible for DNA methylation, and their dysregulation is both a pathogenic
Externí odkaz:
https://doaj.org/article/1b5a843719ae49199b46664b35133c85
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Pulmonary arterial hypertension (PAH) is an orphan disease of the cardiopulmonary unit that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy, inflammation, fibrosis, and ultimately failure of the right ventricle (RVF). Des
Externí odkaz:
https://doaj.org/article/64554359d0784373a842712ef55189d2
Autor:
Stephen L. Archer, Asish Dasgupta, Kuang-Hueih Chen, Danchen Wu, Kaushal Baid, John E. Mamatis, Victoria Gonzalez, Austin Read, Rachel ET. Bentley, Ashley Y. Martin, Jeffrey D. Mewburn, Kimberly J. Dunham-Snary, Gerald A. Evans, Gary Levy, Oliver Jones, Ruaa Al-Qazazi, Brooke Ring, Elahe Alizadeh, Charles CT. Hindmarch, Jenna Rossi, Patricia DA. Lima, Darryl Falzarano, Arinjay Banerjee, Che C. Colpitts
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102508- (2022)
Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary artery smoo
Externí odkaz:
https://doaj.org/article/e159da1d54f348208fca210ce85dc53f
Autor:
Charles Colin Thomas Hindmarch, Lian Tian, Ping Yu Xiong, Francois Potus, Rachel Emily Teresa Bentley, Ruaa Al-Qazazi, Kurt W. Prins, Stephen L. Archer
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Aim: Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy that results in death from right ventricular failure (RVF). There is limited understanding of the molecular mechanisms of RVF in PAH.Methods: In a PAH-RVF model induc
Externí odkaz:
https://doaj.org/article/61645dbb02e24793bfcfd02ab8b072b2
Publikováno v:
Cells, Vol 12, Iss 14, p 1897 (2023)
Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular cal
Externí odkaz:
https://doaj.org/article/9d330491fa2e43b8a841138a76a99e18
Autor:
Mahima Vijayaraghavan, MD, Kurt W. Prins, MD, PhD, Sasha Z. Prisco, MD, PhD, Sue Duval, PhD, Ranjit John, MD, Stephen L. Archer, MD, E. Kenneth Weir, MD, Rochus Voeller, MD, Andrew W. Shaffer, MD, MS, Thenappan Thenappan, MD
Publikováno v:
CJC Open, Vol 3, Iss 4, Pp 488-497 (2021)
Background: The impact of pulmonary hypertension (PH) on outcomes after surgical tricuspid valve replacement (TVR) and repair (TVr) is unclear. We sought to characterize PH in patients undergoing TVR/TVr, based on invasive hemodynamics and evaluate t
Externí odkaz:
https://doaj.org/article/b0757309c8ec4ed28f6dfcacea646636
Autor:
Ping Yu Xiong, MD, Zardasht Jaff, MD, Christine L. D’Arsigny, MD, Stephen L. Archer, MD, Don Thiwanka Wijeratne, MD
Publikováno v:
CJC Open, Vol 2, Iss 5, Pp 328-336 (2020)
Background: Although detection of elevated right ventricular systolic pressure (RVSP) on routine echocardiography is common, its clinical significance is underappreciated. The recent change in the hemodynamic definition of pulmonary hypertension (PH)
Externí odkaz:
https://doaj.org/article/0b08c76942a341f7a8310d7d0f8abae0