Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Stephen L Lessnick"'
Autor:
Davis T Weaver, Kathleen I Pishas, Drew Williamson, Jessica Scarborough, Stephen L Lessnick, Andrew Dhawan, Jacob G Scott
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008755 (2021)
MicroRNA (miRNA)-based therapies are an emerging class of targeted therapeutics with many potential applications. Ewing Sarcoma patients could benefit dramatically from personalized miRNA therapy due to inter-patient heterogeneity and a lack of drugg
Externí odkaz:
https://doaj.org/article/d3d3a5fa7c66497d85ed284850f43e42
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186275 (2017)
Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI chromosomal translocation. The resulting fusion protein is an aberrant transcription factor that uses highly repetitive GGAA-containing elements (micros
Externí odkaz:
https://doaj.org/article/0e5dd21fb6a94abeb452ffac48459372
Autor:
Pavan Kumar P, Uchenna Emechebe, Richard Smith, Sarah Franklin, Barry Moore, Mark Yandell, Stephen L Lessnick, Anne M Moon
Publikováno v:
eLife, Vol 3 (2014)
Cellular senescence is a crucial tumor suppressor mechanism. We discovered a CAPERα/TBX3 repressor complex required to prevent senescence in primary cells and mouse embryos. Critical, previously unknown roles for CAPERα in controlling cell prolifer
Externí odkaz:
https://doaj.org/article/2b3bcf4ed29a4c82897b66af478f6686
Autor:
Michael J Monument, Kirsten M Johnson, Elizabeth McIlvaine, Lisa Abegglen, W Scott Watkins, Lynn B Jorde, Richard B Womer, Natalie Beeler, Laura Monovich, Elizabeth R Lawlor, Julia A Bridge, Joshua D Schiffman, Mark D Krailo, R Lor Randall, Stephen L Lessnick
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104378 (2014)
The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highl
Externí odkaz:
https://doaj.org/article/4751ee6c02754a9b8aa6e02b50c6dade
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59369 (2013)
The EWS/FLI translocation product is the causative oncogene in Ewing sarcoma and acts as an aberrant transcription factor. EWS/FLI dysregulates gene expression during tumorigenesis by abnormally activating or repressing genes. The expression levels o
Externí odkaz:
https://doaj.org/article/6116bd5bc3a94646a34c47a8b40bb2a9
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1965 (2008)
EWS/FLI is a master regulator of Ewing's sarcoma formation. Gene expression studies in A673 Ewing's sarcoma cells have demonstrated that EWS/FLI downregulates more genes than it upregulates, suggesting that EWS/FLI, and/or its targets, function as tr
Externí odkaz:
https://doaj.org/article/b200aafeeafa4aa2a2148449aee92c41
Autor:
Kimberly Stegmaier, Jenny S Wong, Kenneth N Ross, Kwan T Chow, David Peck, Renee D Wright, Stephen L Lessnick, Andrew L Kung, Todd R Golub
Publikováno v:
PLoS Medicine, Vol 4, Iss 4, p e122 (2007)
The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conv
Externí odkaz:
https://doaj.org/article/3348c2ae2b8649059a89ebaf6cc79b72
Autor:
Steven G. DuBois, Mark D. Krailo, Julia Glade-Bender, Allen Buxton, Nadia Laack, R. Lor Randall, Helen X. Chen, Nita L. Seibel, Matthew Boron, Stephanie Terezakis, Christine Hill-Kayser, Andrea Hayes, Joel M. Reid, Lisa Teot, Dinesh Rakheja, Richard Womer, Carola Arndt, Stephen L. Lessnick, Brian D. Crompton, E. Anders Kolb, Heike Daldrup-Link, Eric Eutsler, Damon R. Reed, Katherine A. Janeway, Richard G. Gorlick
Publikováno v:
Journal of Clinical Oncology. 41:2098-2107
PURPOSE Monoclonal antibodies directed against insulin-like growth factor-1 receptor (IGF-1R) have shown activity in patients with relapsed Ewing sarcoma. The primary objective of Children's Oncology Group trial AEWS1221 was to determine if the addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161510daef43486d7607a1274091fcff
https://doi.org/10.1200/jco.22.01815
https://doi.org/10.1200/jco.22.01815
Autor:
Michael D. Kinnaman, Chong Zhu, Daniel A. Weiser, Sana Mohiuddin, Pooja Hingorani, Michael Roth, Jonathan Gill, Katherine A. Janeway, Richard Gorlick, Stephen L. Lessnick, Patrick J. Grohar
Publikováno v:
Sarcoma, Vol 2020 (2020)
Advances in molecular diagnostics have identified subsets of Ewing and Ewing-like sarcomas driven by variant translocations with unique biology. It is likely that patients with these tumours will have different clinical features and therapeutic outco
Externí odkaz:
https://doaj.org/article/0cb2bb6b9dd74e829cda56f08e8b7271
Autor:
Iftekhar A Showpnil, Julia Selich-Anderson, Cenny Taslim, Megann A Boone, Jesse C Crow, Emily R Theisen, Stephen L Lessnick
Publikováno v:
Nucleic Acids Research. 50:9814-9837
Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada230c4af9f84f8be7476f7086a69ac
https://doi.org/10.1093/nar/gkac747
https://doi.org/10.1093/nar/gkac747