Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Stephen L Leib"'
Autor:
Luca G Valente, Ngoc Dung Le, Melissa Pitton, Gabriele Chiffi, Denis Grandgirard, Stephan M Jakob, David R Cameron, Grégory Resch, Yok-Ai Que, Stephen L Leib
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266928 (2022)
BackgroundTreatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including
Externí odkaz:
https://doaj.org/article/09efee4f91354fa48dcd19f870970696
Autor:
Lukas Muri, Simone Oberhänsli, Michelle Buri, Ngoc Dung Le, Denis Grandgirard, Rémy Bruggmann, René M Müri, Stephen L Leib
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232863 (2020)
Pneumococcal meningitis (PM) causes damage to the hippocampus, a brain structure critically involved in learning and memory. Hippocampal injury-which compromises neurofunctional outcome-occurs as apoptosis of progenitor cells and immature neurons of
Externí odkaz:
https://doaj.org/article/cea61d81be134c0691fd0daecddf3f26
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205294 (2018)
Neurotropic tick borne encephalitis virus (TBEV) causes life-threatening disease, and accounts for most cases of tick-transmitted viral infections in Central and Eastern Europe and Russia. No specific treatment for TBEV infections exists, and vaccina
Externí odkaz:
https://doaj.org/article/5c6a433a4d9b473c883f5158322a2530
Autor:
Carole Grädel, Miguel Angel Terrazos Miani, Maria Teresa Barbani, Stephen L Leib, Franziska Suter-Riniker, Alban Ramette
Publikováno v:
Genes, Vol 10, Iss 9, p 659 (2019)
Enteroviruses affect millions of people worldwide and are of significant clinical importance. The standard method for enterovirus identification and genotyping still relies on Sanger sequencing of short diagnostic amplicons. In this study, we assesse
Externí odkaz:
https://doaj.org/article/02aa4848c0c24c40b3480bebf0ae7d29
Autor:
Janine Lux, Hannah Portmann, Lucía Sánchez García, Maria Erhardt, Lalaina Holivololona, Laura Laloli, Manon F. Licheri, Clement Gallay, Robert Hoepner, Nicholas J. Croucher, Daniel Straume, Jan-Willem Veening, Ronald Dijkman, Manfred Heller, Denis Grandgirard, Stephen L. Leib, Lucy J. Hathaway
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Treatment of pneumococcal infections is limited by antibiotic resistance and exacerbation of disease by bacterial lysis releasing pneumolysin toxin and other inflammatory factors. We identified a previously uncharacterized peptide in the Kle
Externí odkaz:
https://doaj.org/article/2a2b48dedc9249f1b222be17efc91b1a
Autor:
Janine Schwitter, Mattia Branca, Antonela Bicvic, Lena S. Abbuehl, Franziska Suter-Riniker, Stephen L. Leib, Anelia Dietmann
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionAn increasing number of studies demonstrate that viral meningitis and meningoencephalitis, even those with a mild course of meningitis, can result in residual sequelae.MethodsWe aimed to investigate the long-term outcome in both viral men
Externí odkaz:
https://doaj.org/article/ecc6696c100e40099de56d5f83b31d55
Autor:
Junhua Wang, Dominique A Vuitton, Norbert Müller, Andrew Hemphill, Markus Spiliotis, Oleg Blagosklonov, Denis Grandgirard, Stephen L Leib, Itay Shalev, Gary Levy, Xiaomei Lu, Renyong Lin, Hao Wen, Bruno Gottstein
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003755 (2015)
BACKGROUND:The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. We previously showed that F
Externí odkaz:
https://doaj.org/article/325e5d26498e430dbc1b2022b2797950
Autor:
Fabian D Liechti, Nicolas Stüdle, Regula Theurillat, Denis Grandgirard, Wolfgang Thormann, Stephen L Leib
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113607 (2014)
Pneumococcal meningitis is associated with high morbidity and mortality rates. Brain damage caused by this disease is characterized by apoptosis in the hippocampal dentate gyrus, a morphological correlate of learning deficits in experimental paradigm
Externí odkaz:
https://doaj.org/article/a872f11bb7a54943944174c1322463d8
Autor:
Fanny Wegner, Blanca Cabrera-Gil, Araud Tanguy, Christiane Beckmann, Niko Beerenwinkel, Claire Bertelli, Matteo Carrara, Lorenzo Cerutti, Chaoran Chen, Samuel Cordey, Alexis Dumoulin, Louis du Plessis, Marc Friedli, Yannick Gerth, Gilbert Greub, Adrian Härri, Hans Hirsch, Cedric Howald, Michael Huber, Alexander Imhof, Laurent Kaiser, Verena Kufner, Stephen L. Leib, Karoline Leuzinger, Etleva Lleshi, Gladys Martinetti, Mirjam Mäusezahl, Milo Moraz, Richard Neher, Oliver Nolte, Alban Ramette, Maurice Redondo, Lorenz Risch, Lionel Rohner, Tim Roloff, Pascal Schläepfer, Katrin Schneider, Franziska Singer, Valeria Spina, Tanja Stadler, Erik Studer, Ivan Topolsky, Alexandra Trkola, Daniel Walther, Nadia Wohlwend, Cinzia Zehnder, Aitana Neves, Adrian Egli
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTDuring the SARS-CoV-2 pandemic, many countries directed substantial resources toward genomic surveillance to detect and track viral variants. There is a debate over how much sequencing effort is necessary in national surveillance programs for
Externí odkaz:
https://doaj.org/article/c4ccaa18016f452ba4419207aed44b4b
Autor:
Alexander Ernst, Indre Piragyte, Ayisha Marwa MP, Ngoc Dung Le, Denis Grandgirard, Stephen L. Leib, Andrew Oates, Nadia Mercader
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied in the context of embryogenesis, thus limiting their administration during pregnancy. Here we used the
Externí odkaz:
https://doaj.org/article/3304dbc4c60f47f495335c5b6a8c0604