Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1.

Autor: Paul Capewell, Nicola J Veitch, C Michael R Turner, Jayne Raper, Matthew Berriman, Stephen L Hajduk, Annette MacLeod

Publikováno v: PLoS Neglected Tropical Diseases, Vol 5, Iss 9, p e1287 (2011)

The three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T. b. gambien

Externí odkaz: https://doaj.org/article/5df15a5e03af48a7b8a438c2cdc4fa37

Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome

Autor: Amrita Sharma, Michael Cipriano, Lori Ferrins, Stephen L. Hajduk, Kojo Mensa-Wilmot

Publikováno v: iScience, Vol 25, Iss 11, Pp 105302- (2022)

Summary: NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell perturbome workflow that

Externí odkaz: https://doaj.org/article/b96c537891464aeab088a311855fedc4

Lexis and grammar of mitochondrial RNA processing in Trypanosomes

Autor: Suzanne M. McDermott, Z. Hong Zhou, H. Ulrich Göringer, Alena Zíková, Kenneth Stuart, Igor Cestari, Reza Salavati, Stephen L. Hajduk, Julius Lukeš, Ruslan Aphasizhev, Dmitri A. Maslov, Jason Carnes, Achim Schnaufer, Inna Aphasizheva, Larry Simpson, Torsten Ochsenreiter, Jorge Cruz-Reyes, Laurie K. Read, André Schneider, Susan Madison-Antenucci, Vyacheslav Yurchenko, Liye Zhang, Juan D. Alfonzo, Sara L. Zimmer

Publikováno v: Aphasizheva, I, Alfonzo, J, Carnes, J, Cestari, I, Cruz-Reyes, J, Göringer, H U, Hajduk, S, Lukeš, J, Madison-Antenucci, S, Maslov, D A, McDermott, S M, Ochsenreiter, T, Read, L K, Salavati, R, Schnaufer, A, Schneider, A, Simpson, L, Stuart, K, Yurchenko, V, Zhou, Z H, Zíková, A, Zhang, L, Zimmer, S & Aphasizhev, R 2020, ' Lexis and grammar of mitochondrial RNA processing in Trypanosomes ', Trends in Parasitology, vol. 36, no. 4, pp. 337-355 . https://doi.org/10.1016/j.pt.2020.01.006
Trends in parasitology, vol 36, iss 4

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171b9f7520b2af84d845636eb4343d1
https://hdl.handle.net/20.500.11820/def562e4-fc49-427d-84a3-da811b3f009b

Drivers of persistent infection: pathogen-induced extracellular vesicles

Autor: Michael J. Cipriano, Stephen L. Hajduk

Publikováno v: Essays in biochemistry. 62(2)

Extracellular vesicles (EVs) are produced by invading pathogens and also by host cells in response to infection. The origin, composition, and function of EVs made during infection are diverse and provide effective vehicles for localized and broad dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e013cd46960ad9ea2f5d57b2e0284b1b
https://pubmed.ncbi.nlm.nih.gov/29666211

Sending a message: extracellular vesicles of pathogenic protozoan parasites

Autor: John M. Harrington, Anthony J. Szempruch, Lauren Dennison, Rudo Kieft, Stephen L. Hajduk

Publikováno v: Nature reviews. Microbiology. 14(11)

Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules through EVs, pathogenic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a073002f9d00ff9adb9a2be12c2f124
https://pubmed.ncbi.nlm.nih.gov/27615028