Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Stephen L, Helfand"'
Autor:
Diana M. Willmes, Martin Daniels, Anica Kurzbach, Stefanie Lieske, Nicole Bechmann, Tina Schumann, Christine Henke, Nermeen N. El-Agroudy, Andrey C. Da Costa Goncalves, Mirko Peitzsch, Anja Hofmann, Waldemar Kanczkowski, Kristin Kräker, Dominik N. Müller, Henning Morawietz, Andreas Deussen, Michael Wagner, Ali El-Armouche, Stephen L. Helfand, Stephan R. Bornstein, Rafael de Cabo, Michel Bernier, Graeme Eisenhofer, Jens Tank, Jens Jordan, Andreas L. Birkenfeld
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restricti
Externí odkaz:
https://doaj.org/article/30014d99d79f40108541ed9b57e5e2ec
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
Autor:
Brian C. Jones, Jason G. Wood, Chengyi Chang, Austin D. Tam, Michael J. Franklin, Emily R. Siegel, Stephen L. Helfand
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The Piwi-interacting RNA (piRNA) pathway is known to suppress transposable elements in gonadal tissues. Here the authors provide evidence for a functional piRNA pathway in the somatic cells of theDrosophilafat body with roles in metabolism, immunolog
Externí odkaz:
https://doaj.org/article/375810040fa843ed8187901066d6abbf
Autor:
Naomi Dirckx, Qian Zhang, Emily Y. Chu, Robert J. Tower, Zhu Li, Shenghao Guo, Shichen Yuan, Pratik A. Khare, Cissy Zhang, Angela Verardo, Lucy O. Alejandro, Angelina Park, Marie-Claude Faugere, Stephen L. Helfand, Martha J. Somerman, Ryan C. Riddle, Rafael de Cabo, Anne Le, Klaus Schmidt-Rohr, Thomas L. Clemens
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Citrate is a critical metabolic substrate and key regulator of energy metabolism in mammalian cells. It has been known for decades that the skeleton contains most (>85%) of the body’s citrate, but the question of why and how this metabolite should
Autor:
Jackson R. Taylor, Jason G. Wood, Evan Mizerak, Samuel Hinthorn, Julianna Liu, Matthew Finn, Sarah Gordon, Louis Zingas, Chengyi Chang, Mark A. Klein, John M. Denu, Vera Gorbunova, Andrei Seluanov, Jef D. Boeke, John M. Sedivy, Stephen L. Helfand
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Sirt6 is well known for its role in regulating the aging process, particularly for its ability to extend lifespan in mice when overexpressed. However, the underlying molecular mechanisms responsible for lifespan regulation by Sirt6 are n
Autor:
Jason G. Wood, Stephen L. Helfand
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Epigenetic regulatory mechanisms are increasingly appreciated as central to a diverse array of biological processes, including aging. An association between heterochromatic silencing and longevity has long been recognized in yeast, and in more recent
Externí odkaz:
https://doaj.org/article/62a1fb69928e41519beb392108d4e6ac
Autor:
Stephen L. Helfand, Rafael de Cabo
Publikováno v:
Nature. 598:265-266
A feeding schedule of prolonged overnight fasting periods extends healthy lifespan in fruit flies by promoting night-time autophagy, a process in which material in cells is degraded and recycled. Autophagy helps flies on an intermittent fasting sched
Autor:
Rafael de Cabo, Michel Bernier, Stefanie Lieske, Mirko Peitzsch, Nermeen N. El-Agroudy, Anja Hofmann, Stephen L. Helfand, Ali El-Armouche, Andreas Deussen, Dominik N. Müller, Graeme Eisenhofer, Jens Tank, S. R. Bornstein, Diana M. Willmes, Nicole Bechmann, Michael Wagner, Andrey C. da Costa Goncalves, Martin A. Daniels, Jens Jordan, Tina Schumann, Henning Morawietz, Anica Kurzbach, Waldemar Kanczkowski, Christine Henke, Kristin Kräker, Andreas L. Birkenfeld
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
JCI insight 6:e136083 (2021)
JCI Insight
JCI insight 6:e136083 (2021)
JCI Insight
Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restricti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327c9d78260d5afae642f656a01b852b
https://elib.dlr.de/144532/
https://elib.dlr.de/144532/
Autor:
Blanka eRogina, Stephen L. Helfand
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Decreased expression of the fly and worm Indy genes extends longevity. The fly Indy gene and its mammalian homolog are transporters of Krebs cycle intermediates, with the highest rate of uptake for citrate. Cytosolic citrate has a role in energy regu
Externí odkaz:
https://doaj.org/article/05eaa78cdc15412c8cfe45034133d65e
Autor:
Paolo Mita, John M. Sedivy, Wilson McKerrow, Fred H. Gage, Trenton A. Woodham, Jef D. Boeke, Jill A. Kreiling, Sara B. Linker, Anna P. Petrashen, Stephen L. Helfand, Andrei Seluanov, Vera Gorbunova, David Fenyö, Jackson Taylor
Publikováno v:
Nature
The genomes of virtually all organisms contain repetitive sequences that are generated by the activity of transposable elements (transposons). Transposons are mobile genetic elements that can move from one genomic location to another; in this process
Autor:
Jens Jordan, Stephen L. Helfand, Tina Schumann, Christine Henke, Alexander Heifetz, Andreas L. Birkenfeld, Anica Kurzbach, Gritt Zahn, Diana M. Willmes
Publikováno v:
Pharmacology & Therapeutics. 185:1-11
The regulation of metabolic processes by the Indy (I'm Not Dead Yet) (SLC13A5/NaCT) gene was revealed through studies in Drosophila melanogaster and Caenorhabditis elegans. Reducing the expression of Indy in these species extended their life span by