Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Stephen K. Wrigley"'
Autor:
James Atherton, Stephen K. Wrigley, Julia Shanu-Wilson, Liam Evans, Jason Boer, Jonathan Steele
Publikováno v:
ACS Med Chem Lett
[Image: see text] Biotransformation has a huge impact on the efficacy and safety of drugs. Ultimately the effects of metabolism can be the lynchpin in the discovery and development cycle of a new drug. This article discusses the impact and applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847152c15944f9f16cdb8d606bd881e9
https://doi.org/10.1021/acsmedchemlett.0c00202
https://doi.org/10.1021/acsmedchemlett.0c00202
Autor:
Bethlehem, Kebede, Stephen K, Wrigley, Anjali, Prashar, Janina, Rahlff, Markus, Wolf, Jeanette, Reinshagen, Philip, Gribbon, Johannes F, Imhoff, Johanna, Silber, Antje, Labes, Bernhard, Ellinger
Publikováno v:
Marine Drugs
As part of an international research project, the marine fungal strain collection of the Helmholtz Centre for Ocean Research (GEOMAR) research centre was analysed for secondary metabolite profiles associated with anticancer activity. Strain MF458 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9eefd451594ed405a28cbfa11b59f772
https://pubmed.ncbi.nlm.nih.gov/28333084
https://pubmed.ncbi.nlm.nih.gov/28333084
Autor:
John R. Ward, Chris rake, Julia Shanu-Wilson, Antonio de Riso, Silvia Bardoni, Headley Williams, Stephen K. Wrigley, Sebastian Schulz, Jonathan Steele, Frank Scheffler, Richard Phipps
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33bf0b7372c850daef50acd95353ba33
https://doi.org/10.1016/j.dmpk.2017.11.121
https://doi.org/10.1016/j.dmpk.2017.11.121
Autor:
Robert Ford, Mario Bouchard, Andrew Whiting, Vivian Miao, Paul Brian, Richard H. Baltz, Marie-Francois Coëffet-Le Gal, Steve Martin, Julia Penn, Trevor Gibson, David A. Kau, Kien T. Nguyen, Jonathan Steele, Stephen K. Wrigley
Publikováno v:
Chemistry & Biology. 13:269-276
SummaryDaptomycin is a lipopeptide antibiotic produced by a nonribosomal peptide synthetase (NRPS) in Streptomyces roseosporus. The holoenzyme is composed of three subunits, encoded by the dptA, dptBC, and dptD genes, each responsible for incorporati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5959da5dd832b37b8f00bbc3dbb6fe
https://doi.org/10.1016/j.chembiol.2005.12.012
https://doi.org/10.1016/j.chembiol.2005.12.012
Autor:
Xiang Li, Vivian Miao, Andrew Whiting, Julian Davies, Mohammed Latif, Richard H. Baltz, Julia Penn, Paul Brian, Christopher J. Silva, Trevor Gibson, Stephen K. Wrigley
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 33:121-128
Daptomycin and the A21978C antibiotic complex are lipopeptides produced by Streptomyces roseosporus and also in recombinant Streptomyces lividans TK23 and TK64 strains, when a 128 kbp region of cloned S. roseosporus DNA containing the daptomycin gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eddb2cfedead9e172337c2737b51a22
https://doi.org/10.1007/s10295-005-0033-8
https://doi.org/10.1007/s10295-005-0033-8
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 33:66-74
Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. Cubicin (daptomycin-for-injection) was approved in 2003 by the FDA to treat skin and skin structure infections caused by Gram-positive pathogens. Daptomycin is partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c41311ec5f3e837cae99ac9335491cd
https://doi.org/10.1007/s10295-005-0030-y
https://doi.org/10.1007/s10295-005-0030-y
Autor:
Ian Parr, Andrew Whiting, Steven M. Martin, Renee Brost, Vivian Miao, Julia Penn, Paul Brian, Richard H. Baltz, Robert Ford, Mario Bouchard, Stephen K. Wrigley, Marie-Françoise Coëffet-LeGal, Christopher J. Silva
Publikováno v:
Microbiology. 151:1507-1523
Daptomycin is a 13 amino acid, cyclic lipopeptide produced by a non-ribosomal peptide synthetase (NRPS) mechanism inStreptomyces roseosporus. A 128 kb region ofS. roseosporusDNA was cloned and verified by heterologous expression inStreptomyces livida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67232a971b42c5b26a56e59e636ed19
https://doi.org/10.1099/mic.0.27757-0
https://doi.org/10.1099/mic.0.27757-0
Autor:
Robert Ford, Steven M. Martin, Martyn Ainsworth, Stephen K. Wrigley, Dudley H. Williams, Sara J. Duncan
Publikováno v:
Tetrahedron Letters. 43:1075-1078
The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71de83f502568c505a01134f28911a96
https://doi.org/10.1016/s0040-4039(01)02239-0
https://doi.org/10.1016/s0040-4039(01)02239-0
Autor:
Stephen K. Wrigley
Publikováno v:
Microbial Diversity and Bioprospecting
Pharmacologically active natural products are generally classified as those useful for treating human diseases and disorders including hyperlipidemia, cancer, immunoregulatory disorders, inflammation, and neurological and metabolic diseases. This cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::894325713669c77bb3eeb5c7ee887543
https://doi.org/10.1128/9781555817770.ch32
https://doi.org/10.1128/9781555817770.ch32
Autor:
Roya Sadeghi, Stephen K. Wrigley, Michael J. Moore, Nina Dhanjal, Brian M. J. Foxwell, Philip B. Rawlins, Paul Depledge, Avi Manic
Publikováno v:
International Immunopharmacology. 1:33-48
Inhibition of CD28 signalling after an immune response impedes T cell activation and can lead to immunosuppression. To identify inhibitors of anti-CD28 induced IL-2 production, a library of fungal metabolites was screened in a cell-based, high throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a3d66aec53be59b80d1872e5a2deed
https://doi.org/10.1016/s1567-5769(00)00008-4
https://doi.org/10.1016/s1567-5769(00)00008-4