Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Stephen K. Siecinski"'
Autor:
William Senapedis, Kayleigh M. Gallagher, Elmer Figueroa, Jeremiah D. Farelli, Robert Lyng, J. Graeme Hodgson, Charles W. O’Donnell, Joseph V. Newman, Madison Pacaro, Stephen K. Siecinski, Justin Chen, Thomas G. McCauley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dysregulation of master regulator c-MYC (MYC) plays a central role in hepatocellular carcinoma (HCC) and other cancers but remains an elusive target for therapeutic intervention. MYC expression is epigenetically modulated within naturally oc
Externí odkaz:
https://doaj.org/article/4f29660da921462b85c500b3d1cb8396
Autor:
George D. Dalton, Stephen K. Siecinski, Viktoriya D. Nikolova, Gary P. Cofer, Kathryn J. Hornburg, Yi Qi, G. Allan Johnson, Yong-Hui Jiang, Sheryl S. Moy, Simon G. Gregory
Publikováno v:
Behavioral and Brain Functions, Vol 20, Iss 1, Pp 1-23 (2024)
Abstract Background Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accompanied by repetitive b
Externí odkaz:
https://doaj.org/article/3a0dc3d8da37446598bf596a2a78dc61
Autor:
William Manley, Michael P Moreau, Marco Azaro, Stephen K Siecinski, Gillian Davis, Steven Buyske, Veronica Vieland, Anne S Bassett, Linda Brzustowicz
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194233 (2018)
Despite much progress, few genetic findings for schizophrenia have been assessed by functional validation experiments at the molecular level. We previously reported evidence for genetic linkage of broadly defined schizophrenia to chromosome 17q25 in
Externí odkaz:
https://doaj.org/article/4e720e5ed6f6456ea4c067d0f03c50da
Autor:
Stephen K. Siecinski, Stephanie N. Giamberardino, Marina Spanos, Annalise C. Hauser, Jason R. Gibson, Tara Chandrasekhar, Maria del Pilar Trelles, Carol M. Rockhill, Michelle L. Palumbo, Allyson Witters Cundiff, Alicia Montgomery, Paige Siper, Mendy Minjarez, Lisa A. Nowinski, Sarah Marler, Lydia C. Kwee, Lauren C. Shuffrey, Cheryl Alderman, Jordana Weissman, Brooke Zappone, Jennifer E. Mullett, Hope Crosson, Natalie Hong, Sheng Luo, Lilin She, Manjushri Bhapkar, Russell Dean, Abby Scheer, Jacqueline L. Johnson, Bryan H. King, Christopher J. McDougle, Kevin B. Sanders, Soo‐Jeong Kim, Alexander Kolevzon, Jeremy Veenstra‐VanderWeele, Elizabeth R. Hauser, Linmarie Sikich, Simon G. Gregory
Publikováno v:
Autism research : official journal of the International Society for Autism ResearchREFERENCES.
Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiolog
Autor:
Jordana Weissman, Lisa A Nowinski, Manjushri Bhapkar, Simon G. Gregory, Jacqueline L. Johnson, Paige M. Siper, Sarah Marler, Allyson Witters Cundiff, Hope Crosson, Christopher J McDougle, Sheng Luo, Russell Dean, Jennifer E Mullett, Michelle L. Palumbo, Carol M Rockhill, Alicia K. Montgomery, Lauren C. Shuffrey, Lilin She, Brooke Zappone, Abby Scheer, Tara Chandrasekhar, Natalie Hong, M. Pilar Trelles, Kevin B. Sanders, Alexander Kolevzon, Bryan H. King, Stephen K Siecinski, Mendy Boettcher Minjarez, Linmarie Sikich, Soo Jeong Kim, Jeremy Veenstra-VanderWeele, Marina Spanos, Cheryl Alderman, Stephanie N Giamberardino
Publikováno v:
The New England journal of medicine, vol 385, iss 16
N Engl J Med
N Engl J Med
BACKGROUND: Experimental studies and small clinical trials have suggested that treatment with intranasal oxytocin may reduce social impairment in persons with autism spectrum disorder. Oxytocin has been administered in clinical practice to many child
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd885147bf3c2be50793f7c07a1d570
https://escholarship.org/uc/item/3t5731hc
https://escholarship.org/uc/item/3t5731hc
Autor:
Chunlei Liu, Stephen K. Siecinski, Simon G. Gregory, Po Han Chen, Eric J. Benner, Mari L. Shinohara, Makoto Inoue, Lawrence Steinman, Qi-Jing Li
Publikováno v:
Nature Neuroscience. 19:1599-1609
Inflammation induced by innate immunity influences the development of T cell-mediated autoimmunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). We found that strong activation of innate immunity induced
Autor:
Alexandra L. Bey, Stephen K. Siecinski, Simon G. Gregory, Leeyup Chung, Wei Xie, Xinyu Cao, Aaron J. Towers, Xiangyin Kong, Xin-lei Li, Sonia Xu, Lara J. Duffney, Martine W. Tremblay, Xiaoming Wang, Ping Wang, Yong-hui Jiang, Wen-Hao Zhang, Yuna Kim
Publikováno v:
JCI insight. 3(23)
OXTR modulates a variety of behaviors in mammals, including social memory and recognition. Genetic and epigenetic dysregulation of OXTR has been suggested to be implicated in neuropsychiatric disorders, including autism spectrum disorder (ASD). While
Autor:
Stephen K. Siecinski, Michael P. Moreau, Linda M. Brzustowicz, Veronica J. Vieland, Marco A. Azaro, William Manley, Steven Buyske, Gillian Davis, Anne S. Bassett
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194233 (2018)
PLoS ONE
PLoS ONE
Despite much progress, few genetic findings for schizophrenia have been assessed by functional validation experiments at the molecular level. We previously reported evidence for genetic linkage of broadly defined schizophrenia to chromosome 17q25 in