Phenotypic and molecular characterization of beta-lactam resistant Multidrug-resistant Enterobacterales isolated from patients attending six hospitals in Northern Nigeria

Autor: Nubwa Medugu, Isabella A. Tickler, Carissa Duru, Ruth Egah, Abu Ocheiku James, Vivian Odili, Fatima Hanga, Eyinade Kudirat Olateju, Binta Jibir, Bernard E. Ebruke, Grace Olanipekun, Fred C. Tenover, Stephen K. Obaro

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Infections caused by multi-drug resistant Enterobacterales (MDR-E) are difficult to treat and cause significant mortality, especially in developing countries. This study characterized the phenotypic and genotypic profiles of 49 randomly sele

Externí odkaz: https://doaj.org/article/0a8c486335d344b380f428ac12975473

A Prospective Cohort Study of the Clinical Predictors of Bacteremia in Under-Five Children With Acute Undifferentiated Fever Attending a Secondary Health Facility in Northwestern Nigeria

Autor: Taofik Oluwaseun Ogunkunle, Timothy Olanrewaju Adedoyin, Samuel Kolade Ernest, Fatimah Hassan-Hanga, Abdulazeez Imam, Rasaq Olaosebikan, Stephen K. Obaro

Publikováno v: Frontiers in Pediatrics, Vol 9 (2022)

BackgroundChildren with acute febrile illness with no localizing signs often receive antibiotics empirically in most resource-poor settings. However, little is known about the burden of bacteremia in this category of patients, and an appraisal is thu

Externí odkaz: https://doaj.org/article/b6485d71a46244f4b85b4bebc5ae3ce4

Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link?

Autor: Seah H. Lim, Barbara A. Methé, Bettina M. Knoll, Alison Morris, Stephen K. Obaro

Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-7 (2018)

Abstract Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the organism causes serious and pot

Externí odkaz: https://doaj.org/article/d8624bd3413743e6b0199b66ac03675d

Emergence of New Delhi Metallo-β-Lactamase (NDM-5) in Klebsiella quasipneumoniae from Neonates in a Nigerian Hospital

Autor: Lauren M. Brinkac, Richard White, Roshan D’Souza, Kevin Nguyen, Stephen K. Obaro, Derrick E. Fouts

Publikováno v: mSphere, Vol 4, Iss 2 (2019)

ABSTRACT Outbreaks of infection occur more often than they are reported in most developing countries, largely due to poor diagnostic services. A Klebsiella species bacteremia outbreak in a newborn unit with high mortality was recently encountered at

Externí odkaz: https://doaj.org/article/31e9405bd3224f329ab1527fa7a2ff3f

Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

Autor: Stephanie W Lo, Kate Mellor, Robert Cohen, Alba Redin Alonso, Sophie Belman, Narender Kumar, Paulina A Hawkins, Rebecca A Gladstone, Anne von Gottberg, Balaji Veeraraghavan, K L Ravikumar, Rama Kandasamy, Sir Andrew J Pollard, Samir K Saha, Godfrey Bigogo, Martin Antonio, Brenda Kwambana-Adams, Shaper Mirza, Sadia Shakoor, Imran Nisar, Jennifer E Cornick, Deborah Lehmann, Rebecca L Ford, Betuel Sigauque, Paul Turner, Jennifer Moïsi, Stephen K Obaro, Ron Dagan, Idrissa Diawara, Anna Skoczyńska, Hui Wang, Philip E Carter, Keith P Klugman, Gail Rodgers, Robert F Breiman, Lesley McGee, Stephen D Bentley, Carmen Muñoz-Almagro, Emmanuelle Varon, Abdullah Brooks, Alejandra Corso, Alexander Davydov, Alison Maguire, Anmol Kiran, Benild Moiane, Bernard Beall, Chunjiang Zhao, David Aanensen, Dean Everett, Diego Faccone, Ebenezer Foster-Nyarko, Ebrima Bojang, Ekaterina Egorova, Elena Voropaeva, Eric Sampane-Donkor, Ewa Sadowy, Geetha Nagaraj, Helio Mucavele, Houria Belabbès, Naima Elmdaghri, Jennifer Verani, Jeremy Keenan, John Lees, Jyothish N Nair Thulasee Bhai, Kedibone Ndlangisa, Khalid Zerouali, Leon Bentley, Leonid Titov, Linda De Gouveia, Maaike Alaerts, Margaret Ip, Maria Cristina de Cunto Brandileone, Md Hasanuzzaman, Metka Paragi, Michele Nurse-Lucas, Mignon du Plessis, Mushal Ali, Nicholas Croucher, Nicole Wolter, Noga Givon-Lavi, Nurit Porat, Özgen Köseoglu Eser, Pak-Leung Ho, Patrick Eberechi Akpaka, Paula Gagetti, Peggy-Estelle Tientcheu, Pierra Law, Rachel Benisty, Rafal Mostowy, Roly Malaker, Samanta Cristine Grassi Almeida, Sanjay Doiphode, Shabir Madhi, Shamala Devi Sekaran, Stuart Clarke, Somporn Srifuengfung, Susan Nzenze, Tamara Kastrin, Theresa Ochoa, Waleria Hryniewicz, Yulia Urban

Publikováno v: The Lancet Microbe. 3:e735-e743

Background Serotype 24F is one of the emerging pneumococcal serotypes after the introduction of pneumococcal conjugate vaccine (PCV). We aimed to identify lineages driving the increase of serotype 24F in France and place these findings into a global

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e81bdf0d79c33a23902726bdb023c2a
https://doi.org/10.1016/s2666-5247(22)00158-6