Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephen K-F. Wong"'
Publikováno v:
BioTechniques, Vol 33, Iss 4, Pp 932-937 (2002)
Here we describe a fully automated, hands-free radioligand filtration binding assay for dopamine D3 receptors. Three separate instruments were linked in tandem to perform the following operations: The Genmate and Genesis were linked to perform liquid
Externí odkaz:
https://doaj.org/article/4bf5e9699c7f4b37a0352568f20648dc
Autor:
Denise J. Burring, Carly L. Nichols, Vivienne Sanderson, David V. Batchelor, Charlotte Moira Norfor Allerton, Andrew Simon Cook, Julian Blagg, Joanne Phipps, Hugh Verrier, Stephen K.-F. Wong, Andrew Douglas Baxter, Christopher L. Carr
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6691-6696
This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb0e1aac944b12f621b121b1b4a63c5
https://doi.org/10.1016/j.bmcl.2007.10.059
https://doi.org/10.1016/j.bmcl.2007.10.059
Publikováno v:
SLAS Discovery. 10:524-531
A fully automated, solid-to-solid weighing workstation (patent pending) is described in this article. The core of this automated process is the use of an electrostatically charged pipette tip to attract solid particles on its outside surface. The par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a93c40e287d964c0e89c1d9b93ed5a4
https://doi.org/10.1177/1087057105275457
https://doi.org/10.1177/1087057105275457
Autor:
Robert Sibley, Dixon Brian R, David R. Brittelli, Gerhard Konig, Stephen K.-F. Wong, Jinshan Chen, Jacques Dumas, James A. Witowsky, Holia Hatoum-Mokdad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2531-2536
Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9945f38931580e17ee0a67bee5985d2
https://doi.org/10.1016/s0960-894x(99)00433-3
https://doi.org/10.1016/s0960-894x(99)00433-3
Publikováno v:
Brain Research. 738:196-204
Alzheimer's disease is primarily characterized by neurofibrillary tangles, senile plaques, and neurodegeneration. The major component of senile plaques is the beta-amyloid peptide (beta A4), which has been shown to be toxic to neurons in vitro. To da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1259e98aae80fa4cf3098c08d4fe88d
https://doi.org/10.1016/s0006-8993(96)00733-0
https://doi.org/10.1016/s0006-8993(96)00733-0
Autor:
Stephen K.-F. Wong
Publikováno v:
Handbook of Assay Development in Drug Discovery ISBN: 9781574444711
Handbook of Assay Development in Drug Discovery
Handbook of Assay Development in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be65c30e0aed92aa61867eb00b8f3e9b
https://doi.org/10.1201/9781420015706.ch12
https://doi.org/10.1201/9781420015706.ch12
Autor:
Stephen K.-F. Wong
Publikováno v:
Analytical biochemistry. 333(2)
Phosphorylation of extracellular signal-regulated kinase (ERK) is linked to activation of many cell surface receptors and kinases. However, phosphorylated ERK has not been used as a biochemical marker to monitor pharmacology of these biomolecules, la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55035ef71b40f1827b18479dc55356b
https://pubmed.ncbi.nlm.nih.gov/15450801
https://pubmed.ncbi.nlm.nih.gov/15450801
Publikováno v:
European journal of pharmacology. 475(1-3)
The role of dopamine D3 receptors was investigated in mediating the neuroprotective effect of the dopamine D2/D3 receptor agonist (S)-2-amino-4,5,6,7-tetrahydro-6-propylamine-benzothiazole (pramipexole) in vivo. Pramipexole retained the ability to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9d5f4158b8f76ce7725771dd1c3b2f
https://pubmed.ncbi.nlm.nih.gov/12954356
https://pubmed.ncbi.nlm.nih.gov/12954356
Autor:
Stephen K.-F. Wong, Donald Wayne Smith, M. Mcconkey, Alka Shrikhande, J. Bergeron, Carter Courtney, M. Melch
Publikováno v:
BioTechniques. 33(4)
Here we describe a fully automated, hands-free radioligand filtration binding assay for dopamine D3 receptors. Three separate instruments were linked in tandem to perform the following operations: The Genmate and Genesis were linked to perform liquid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c2a2c547cb4059bda0ce4a80c63cc4
https://pubmed.ncbi.nlm.nih.gov/12398203
https://pubmed.ncbi.nlm.nih.gov/12398203
Autor:
Stephen K.-F. Wong
Publikováno v:
Neuro-Signals. 12(1)
GTP-binding protein coupled receptors (GPCRs) bind to a vast diversity of extracellular ligands to regulate a wide variety of physiological responses. Upon binding of extracellular ligands, these seven-transmembrane-spanning receptor molecules couple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14aeb945a21fa0ecbd89d5a30f098a6
https://pubmed.ncbi.nlm.nih.gov/12624524
https://pubmed.ncbi.nlm.nih.gov/12624524