Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Stephen John Ralph"'
Autor:
Diana Xochiquetzal Robledo-Cadena, Juan Carlos Gallardo-Pérez, Víctor Dávila-Borja, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Stephen John Ralph, Betsy Alejandra Blanco-Carpintero, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
Publikováno v:
Pharmaceuticals, Vol 13, Iss 12, p 463 (2020)
This study shows that the non-steroidal anti-inflammatory drug (NSAID) celecoxib and its non-cyclooxygenase-2 (COX2) analogue dimethylcelecoxib (DMC) exert a potent inhibitory effect on the growth of human cervix HeLa multi-cellular tumor spheroids (
Externí odkaz:
https://doaj.org/article/134dac971f804a488c2cc2d6398ae07c
Autor:
Stephen John Ralph, Rhys Pritchard, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez, Raymond Keith Ralph
Publikováno v:
Pharmaceuticals, Vol 8, Iss 1, Pp 62-106 (2015)
Tumor metastases that impede the function of vital organs are a major cause of cancer related mortality. Mitochondrial oxidative stress induced by hypoxia, low nutrient levels, or other stresses, such as genotoxic events, act as key drivers of the ma
Externí odkaz:
https://doaj.org/article/356b8a6043b341c1b83b0907029c65c4
Publikováno v:
Cancer Immunology, Immunotherapy. 72:527-542
Neutrophils have recently gained recognition for their potential in the fight against cancer. Neutrophil plasticity between the N1 anti-tumor and N2 pro-tumor subtypes is now apparent, as is the ability to polarize these individual subtypes by interv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e0d298f4f51ba686c0dbae7594db6d
https://doi.org/10.1007/s00262-022-03248-8
https://doi.org/10.1007/s00262-022-03248-8
Autor:
Frank J Echtenkamp, Ryo Ishida, Genesis M Rivera-Marquez, Marisa Maisiak, Oleta T Johnson, Jonathan H Shrimp, Arnav Sinha, Stephen John Ralph, Ian Nisbet, Murali Krishna Cherukuri, Jason E Gestwicki, Leonard M Neckers
Publikováno v:
PNAS Nexus
PNAS nexus, vol 2, iss 4
PNAS nexus, vol 2, iss 4
The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c14ec7cbf7dcddfe214f2794fc2679b
https://europepmc.org/articles/PMC10118397/
https://europepmc.org/articles/PMC10118397/
Autor:
Pauline Low, Chandi Magawa, Stephen John Ralph, Adriana Pliego-Zamora, Max Reynolds, Amanda M. Clark
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss, Pp 111790-(2021)
The antitumor activity of the tea tree oil (TTO) derived product, Melaleuca Alternifolia Concentrate (MAC) was characterized mechanistically at the molecular and cellular level. MAC was analyzed for its anticancer activity against human prostate (LNC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b26b18559937596f6963d04fada269
https://pubmed.ncbi.nlm.nih.gov/34119930
https://pubmed.ncbi.nlm.nih.gov/34119930
Autor:
Javier Alejandro Belmont-Díaz, Sara Rodríguez-Enríquez, Víctor M. Dávila-Borja, Juan Carlos Gallardo-Pérez, Betsy Alejandra Blanco-Carpintero, Rafael Moreno-Sánchez, Silvia Cecilia Pacheco-Velázquez, Stephen John Ralph, Diana Xochiquetzal Robledo-Cadena
Publikováno v:
Pharmaceuticals
Volume 13
Issue 12
Pharmaceuticals, Vol 13, Iss 463, p 463 (2020)
Volume 13
Issue 12
Pharmaceuticals, Vol 13, Iss 463, p 463 (2020)
This study shows that the non-steroidal anti-inflammatory drug (NSAID) celecoxib and its non-cyclooxygenase-2 (COX2) analogue dimethylcelecoxib (DMC) exert a potent inhibitory effect on the growth of human cervix HeLa multi-cellular tumor spheroids (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d29a17f0f22415d6498aee0f73584ec
Autor:
Ventzislav Bonev, Mikaela D. Bonham, Samantha Ferguson, Adrienne A. Goodman-Jones, Anthony J. Espinet, Stephen John Ralph, Liam King, Ashley Smith, Andrew Weissenberger
Previous open-label studies showed that chronic post-stroke pain could be abated by treatment with perispinal etanercept, although these benefits were questioned. A randomized double-blind placebo controlled clinical trial was conducted to test peris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3491ddb50069651f5138077c9dde9e
Autor:
Silvia Cecilia Pacheco-Velázquez, Rafael Moreno-Sánchez, Vuk Bortnik, Stephen John Ralph, Rhys Pritchard, Sara Rodríguez-Enríquez
Publikováno v:
Biochemical Pharmacology. 154:318-334
Capecitabine induced toxicities such as hand-foot syndrome (HFS) and progression of metastatic cancer are both treatable with concurrent celecoxib as shown in the ADAPT (Activating Cancer Stem Cells from Dormancy And Potentiate for Targeting) trial.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e28831e2b7fb384045546ae5f2d054e
https://doi.org/10.1016/j.bcp.2018.05.013
https://doi.org/10.1016/j.bcp.2018.05.013
Autor:
Stephen John Ralph, Anthony J. Espinet
Publikováno v:
Journal of Alzheimer's Disease Reports
It is almost ten years since the Banerjee 2009 report established that inappropriate prescribing of antipsychotics in the elderly was occurring in the UK and such patients had an 85% increased risk of adverse events and greater mortality. This report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a37202fa14768075400276e123d93a9
https://doi.org/10.3233/adr-170042
https://doi.org/10.3233/adr-170042
Autor:
Reem Ali ALHulais, Stephen John Ralph, Sam Nozuhur, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
Publikováno v:
Medicinal research reviews. 39(6)
Over the last decade, three major advances have contributed in improving the response rates against cancer including, immunotherapy; greater understanding of the molecular, biochemical, and cellular mechanisms in carcinogenesis thereby providing drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f20858a6d0cb88824f309ad924e46e
https://pubmed.ncbi.nlm.nih.gov/31111530
https://pubmed.ncbi.nlm.nih.gov/31111530