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pro vyhledávání: '"Stephen Jelfs"'
Autor:
Stephen Jelfs, Peter Ertl
Publikováno v:
Current Topics in Medicinal Chemistry. 7:1491-1501
The drug discovery process is supported by a multitude of freely available tools on the Internet. This paper summarizes some of the databases and tools that are of particular interest to medicinal chemistry. These include numerous data collections th
Publikováno v:
Journal of Chemical Information and Modeling. 47:450-459
A pragmatic approach has been developed for the estimation of aqueous ionization constants (pKa) for druglike compounds. The method involves an algorithm that assigns ionization constants in a stepwise manner to the acidic and basic groups present in
Autor:
Gurdip Bhalay, David Beer, Stephen Paul Collingwood, Sarah Craig, Nicholas James Devereux, Rowan Stringer, Sandra Haberthuer, Trevor John Howe, Angela Glen, Katharine L. Turner, Andrew Dunstan, Heinz E. Moser, Ruth Arnold, Mauro Zurini, Sylvie Gomez, Paul Nicklin, Simon J. Watson, Urs Baettig, Reto Naef, David Andrew Sandham, Stephen Jelfs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2587-2590
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in man
Publikováno v:
Journal of medicinal chemistry. 49(15)
Bioactive molecules only contain a relatively limited number of unique ring types. To identify those ring properties and structural characteristics that are necessary for biological activity, a large virtual library of nearly 600 000 heteroaromatic s
Publikováno v:
Journal of Chemical Information & Modeling; Mar2007, Vol. 47 Issue 2, p450-459, 10p