Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stephen Jaspers"'
Autor:
Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscl
Externí odkaz:
https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d9
Autor:
Marisa Carbonaro, Kehui Wang, Hui Huang, Davor Frleta, Aditi Patel, Alexander Pennington, Mathieu Desclaux, Sven Moller-Tank, Justin Grindley, Judith Altarejos, Jun Zhong, Greg Polites, William Poueymirou, Stephen Jaspers, Christos Kyratsous, Brian Zambrowicz, Andrew Murphy, John C. Lin, Lynn E. Macdonald, Christopher Daly, Mark Sleeman, Gavin Thurston, Zhe Li
Publikováno v:
Science Advances. 9
Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here
Autor:
Jason Mastaitis, Andrew J. Murphy, Jesus A. Trejos, Stephen Jaspers, Jeffrey Pangilinan, Trevor Stitt, Erqian Na, Esther Latres, Yu Bai, George D. Yancopoulos, Lawrence Miloscio, Jesper Gromada, Ashique Rafique, Wen Fury, Jee Hae Kim, Tobias Willer, Katie Cavino, Haruka Okamoto, Angelos Papatheodorou
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man. Broad T
Autor:
Julia, Parrish-Novak, Wenfeng, Xu, Ty, Brender, Lena, Yao, Crystal, Jones, Jim, West, Cameron, Brandt, Laura, Jelinek, Karen, Madden, Patricia A, McKernan, Donald C, Foster, Stephen, Jaspers, Yasmin A, Chandrasekher
Publikováno v:
The Journal of biological chemistry. 277(49)
Cytokines that signal through Class II receptors form a distinct family that includes the interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has defined a cytokine subfamily that includes AK155, IL-19, IL-20, IL-2
Autor:
Brian E. Wadzinski, William H. Wheat, Stephen Jaspers, Leonard F. Peruski, Ronald L. Lickteig, Gary L. Johnson, Dwight J. Klemm
Cyclic AMP (cAMP)-dependent protein kinase A (PKA) stimulates the transcription of many eucaryotic genes by catalyzing the phosphorylation of the cAMP-regulatory element binding protein (CREB). Conversely, the attenuation or inhibition of cAMP-stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11a870fa29e36c0db6bbfc201b1eaf7
https://europepmc.org/articles/PMC359667/
https://europepmc.org/articles/PMC359667/