Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Stephen J. Waters"'
Autor:
Jeremy Webber, John R. MacDonald, Emily S. Van Laar, Yan Zhang, Kevin H. Mayo, Ruud P.M. Dings, Robert J. Griffin, Stephen J. Waters
Publikováno v:
Cancer Letters. 265:270-280
Combination of chemotherapeutic agents and angiogenesis inhibitors is now commonly employed in the clinic to treat cancer. Here, we used angiostatic agents anginex and 0118, in combination with the chemotherapeutic irofulven, to treat human ovarian t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2d5890b42c83c9112be20aa886a6e6
https://doi.org/10.1016/j.canlet.2008.02.048
https://doi.org/10.1016/j.canlet.2008.02.048
Autor:
Florence Koeppel, Esteban Cvitkovic, Eric Raymond, Maria Serova, Annette K. Larsen, Stephen J. Waters, Fabien Calvo, Emily S. Van Laar, François Lokiec, V. Poindessous
Publikováno v:
Cancer Chemotherapy and Pharmacology. 57:491-499
Purpose: This study assessed the cytotoxic effects of irofulven in combination with oxaliplatin and cisplatin in a panel of human cancer cell lines. Methods: Growth inhibition studies were performed using the human HT29 colon cancer cell line, iroful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850071870c8b138aacf07599a40b1e0f
https://doi.org/10.1007/s00280-005-0063-y
https://doi.org/10.1007/s00280-005-0063-y
Autor:
Huiyun Liang, Richard A. Salinas, Belinda Z. Leal, Teresa Kosakowska-Cholody, Christopher J. Michejda, Stephen J. Waters, Terence S. Herman, Jan M. Woynarowski, Barbara A. Woynarowska
Publikováno v:
Molecular Cancer Therapeutics. 3:1385-1396
Irofulven (hydroxymethylacylfulvene) is a novel antitumor drug, which acts by alkylating cellular macromolecular targets. The drug is a potent inducer of apoptosis in various types of tumor cells, whereas it is nonapoptotic in normal cells. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8fa92147f4f70acd22f299fb0ea2d8
https://doi.org/10.1158/1535-7163.1385.3.11
https://doi.org/10.1158/1535-7163.1385.3.11
Autor:
Stephen J. Waters, John R. MacDonald, Alex V. Trevino, Jan M. Woynarowski, Richard A. Salinas, Terence S. Herman, Barbara A. Woynarowska
Publikováno v:
Cancer Biology & Therapy. 3:1137-1142
Unlike postmitotic cell death, direct premitotic apoptosis diminishes the risk of clonal selection and allows for the elimination of slowly growing cancer cells. This study characterized the ability to induce premitotic apoptosis by irofulven (hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3997526cf7231c1a84bc6eb6804f7018
https://doi.org/10.4161/cbt.3.11.1216
https://doi.org/10.4161/cbt.3.11.1216
Autor:
Elzbieta Izbicka, John R. MacDonald, E. S. Van Laar, Leticia Medina-Gundrum, Steven D. Weitman, Stephen J. Waters
Publikováno v:
International Journal of Gynecologic Cancer. 14:824-831
The objective of this study was to investigate the cytotoxic activity of irofulven (HMAF, MGI 114), a unique chemotherapeutic agent currently under clinical investigation, in various preclinical models of ovarian cancer. Antiproliferative effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ed1dfe1bb026512e5de451a7ce09cf
https://doi.org/10.1136/ijgc-00009577-200409000-00013
https://doi.org/10.1136/ijgc-00009577-200409000-00013
Publikováno v:
Investigational New Drugs. 19:283-291
Irofulven (hydroxymethylacylfulvene, HMAF, MGI 114) is a novel agent with alkylating activity and a potent inducer of apoptosis. It is currently undergoing Phase II clinical trials for several tumor types, including hormone-refractory prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a24718e83b227b454c30bdd8729b11
https://doi.org/10.1023/a:1010601524630
https://doi.org/10.1023/a:1010601524630
Autor:
Michael J. Kelner, Jian Yu, Ricardo Lira, Stephen J. Waters, John R. MacDonald, Robin Dawe, Leita A. Estes, Trevor C. McMorris
Publikováno v:
The Journal of Organic Chemistry. 66:6158-6163
Many analogues of the antitumor agent irofulven have been readily prepared by replacing the allylic hydroxyl with a variety of nucleophiles. Analogues of acylfulvene (the precursor to irofulven) were also prepared by Michael reaction with acrolein. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141a02419870be260603e82a34b8b51
https://doi.org/10.1021/jo010458z
https://doi.org/10.1021/jo010458z
Autor:
Emily S. Van Laar, Ruud P.M. Dings, Yan Zhang, John R. MacDonald, Kevin H. Mayo, Stephen J. Waters, Melissa L. Loren, Jeremy Webber
Publikováno v:
Bioconjugate chemistry. 21(1)
Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6-hydroxypropylacylfulvene (HPAF) to anginex, a peptide that targets galectin-1, which is highly expressed in endothelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d4bcb9dd5144c338ec7297a45d05b5
https://pubmed.ncbi.nlm.nih.gov/20020769
https://pubmed.ncbi.nlm.nih.gov/20020769
Autor:
David M. Green, Ralph E. Manns, Harold L. Schramm, Anthony J. Fedler, Jeffery L. Hahn, Michael L. Armstrong, Stephen J. Waters, Stephen P. Quinn, Nicholas A. Funicelli, Dennis P. Lee
Publikováno v:
Fisheries. 16:13-21
Competitive fishing is a large and growing use of fishery resources that offers benefits and creates problems for fishery managers. Successful integration of competitive fishing with noncompetitive anglers and other aquatic resource users will requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54fdf0cf20b93aa1a6b3a532c86876b8
https://doi.org/10.1577/1548-8446(1991)016<0013:seabao>2.0.co
https://doi.org/10.1577/1548-8446(1991)016<0013:seabao>2.0.co
Autor:
Stephen J. Waters, Dennis P. Lee, Nicholas A. Funicelli, Harold L. Schramm, Bruce D. Taubert, David M. Green, Michael L. Armstrong, Ralph E. Manns
Publikováno v:
Fisheries. 16:4-12
Organized competitive sportfishing has been a growing use of fishery resources for at least the last 20 years. We conducted a survey of fishery agencies in Canada, the United States, District of Columbia, Puerto Rico, and U.S. Virgin Islands to estim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c6b0c61bc9d2740910d71e70c40d15
https://doi.org/10.1577/1548-8446(1991)016<0004:tsocsf>2.0.co
https://doi.org/10.1577/1548-8446(1991)016<0004:tsocsf>2.0.co