Výsledky vyhledávání - "Stephen J. Ralph"

Akademický článek

Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression

Autor: Amanda M. Clark, Chandi Magawa, Adriana Pliego-Zamora, Pauline Low, Max Reynolds, Stephen J. Ralph

Publikováno v: Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111790- (2021)

The antitumor activity of the tea tree oil (TTO) derived product, Melaleuca Alternifolia Concentrate (MAC) was characterized mechanistically at the molecular and cellular level. MAC was analyzed for its anticancer activity against human prostate (LNC

Externí odkaz: https://doaj.org/article/9ff7c89257574419a305f5122981b122

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Akademický článek

Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3

Autor: Samuel J. Cutler, James D. Doecke, Ibtisam Ghazawi, Jinbo Yang, Lyn R. Griffiths, Kevin J. Spring, Stephen J. Ralph, Albert S. Mellick

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflam

Externí odkaz: https://doaj.org/article/e8b635bf4b804c1283b84d769ec90929

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Akademický článek

Human T Cell Leukemia Virus Type I Tax-Induced IκB-ζ Modulates Tax-Dependent and Tax-Independent Gene Expression in T Cells

Autor: Ryuichiro Kimura, Masachika Senba, Samuel J. Cutler, Stephen J. Ralph, Gutian Xiao, Naoki Mori

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 9, Pp 1110-1124 (2013)

Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia (ATL) and various inflammatory disorders including HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I oncoprotein Tax is known to cause permane

Externí odkaz: https://doaj.org/article/7bf2d0f8f7644fc58587a2ece4a92585

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Data from REST Negatively and ISGF3 Positively Regulate the Human STAT1 Gene in Melanoma

Autor: Stephen J. Ralph, Glen M. Boyle, Ibtisam Ghazawi, Samuel J. Cutler, James Amalraj

STAT1 plays a pivotal role in signal transduction and transcriptional activation in response to type I and II IFNs. Regulation of STAT1 expression has significant consequences in human cancer cells, where STAT1 deficiencies have been associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7037a0c7978e037f7dcedd0996d6bd9d
https://doi.org/10.1158/1535-7163.c.6536776.v1

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Supplementary Figures 1 - 7, Tables 1 - 4 from REST Negatively and ISGF3 Positively Regulate the Human STAT1 Gene in Melanoma

Autor: Stephen J. Ralph, Glen M. Boyle, Ibtisam Ghazawi, Samuel J. Cutler, James Amalraj

PDF file - 675K, Supplementary Figure 1. Characterization of an ISRE in the human STAT1 gene promoter. Supplementary Figure 2. ChIP assay demonstrates binding of REST to the STAT1 RE-1 element in melanoma cell lines. Supplementary Figure 3. Full-leng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ec13fe92c3505f05f817294f8da257
https://doi.org/10.1158/1535-7163.22501393

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