Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Stephen J. Raithel"'
1
Long-term pain relief in canine osteoarthritis by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist
Autor: Andrew J. Mannes, Matthew R. Sapio, Stephen J. Raithel, Dorothy Cimino Brown, Michael J. Iadarola
Publikováno v: Pain
The translational potential of analgesic approaches emerging from basic research can be augmented by client-owned dog trials. We report on a peripheral interventional approach that uses intra-articular injection of the ultrapotent TRPV1 agonist resin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28c7b8f87b57a5e6e964bd30cea323c
https://doi.org/10.1097/j.pain.0000000000001314
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2
Thermal A-δ Nociceptors, Identified by Transcriptomics, Express Higher Levels of Anesthesia-Sensitive Receptors Than Thermal C-Fibers and Are More Suppressible by Low-Dose Isoflurane
Autor: Andrew J. Mannes, Stephen J. Raithel, Matthew R. Sapio, Michael J. Iadarola
Publikováno v: Anesth Analg
We investigated the effect of isoflurane on 2 main types of thermal nociceptors: A-δ and C-fibers. Surprisingly, 1% inhaled isoflurane led to a hyperalgesic response to C-fiber thermal stimulation, whereas responses to A-δ thermal stimulation were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ace580151fdba046137b641058c9d3f
https://doi.org/10.1213/ane.0000000000002505
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3
Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons
Autor: Jason M. Keller, Stephen J. Raithel, Eric L. Rohrs, Andrew J. Mannes, Robert M. Caudle, Ethan M. Anderson, Dragan Maric, John A. Butman, Matthew R. Sapio, Dorothy Cimino Brown, Danielle M. LaPaglia, John K. Neubert, John D. Heiss, Michael J. Iadarola
Publikováno v: Journal of Clinical Investigation. 128:1657-1670
Agonists of the vanilloid receptor transient vanilloid potential 1 (TRPV1) are emerging as highly efficacious nonopioid analgesics in preclinical studies. These drugs selectively lesion TRPV1+ primary sensory afferents, which are responsible for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fdf786c3ddd595eae322ea1a8952ce
https://doi.org/10.1172/jci94331
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4
Transcriptional Changes in Dorsal Spinal Cord Persist after Surgical Incision Despite Preemptive Analgesia with Peripheral Resiniferatoxin
Autor: Danielle M. LaPaglia, Michael J. Iadarola, Andrew J. Mannes, Matthew R. Sapio, Stephen J. Raithel
Publikováno v: Anesthesiology. 128:620-635
Background Peripheral nociceptors expressing the ion channel transient receptor potential cation channel, subfamily V, member 1, play an important role in mediating postoperative pain. Signaling from these nociceptors in the peri- and postoperative p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ad515968824005082628574052707d
https://doi.org/10.1097/aln.0000000000002006
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5
RNA-Seq investigations of human post-mortem trigeminal ganglia
Autor: Danielle Thierry-Mieg, Peter D. Burbelo, Michael J. Iadarola, Stephen J. Raithel, Christopher E. Ramsden, Andrew J. Mannes, Danielle M. LaPaglia, Jean Thierry-Mieg, Matthew R. Sapio
Publikováno v: Cephalalgia. 38:912-932
Background The trigeminal ganglion contains neurons that relay sensations of pain, touch, pressure, and many other somatosensory modalities to the central nervous system. The ganglion is also a reservoir for latent herpes virus 1 infection. To gain a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd52101a62b7ad8cfd2627b0baceffc7
https://doi.org/10.1177/0333102417720216
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6
Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception
Autor: John Joseph, Harish C. Pant, Bradford Hall, Stephen J. Raithel, Natalya Kurochkina, Man-Kyo Chung, B K Binukumar, Paul D. Minetos, Anita Terse, Andrew J. Mannes, Michaela Prochazkova, Niranjana D. Amin, Michael J. Iadarola, Ashok B. Kulkarni, Matthew R. Sapio
Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Cyclin-dependent kinase 5 (Cdk5) is a key neuronal kinase that is upregulated during inflammation, and can subsequently modulate sensitivity to nociceptive stimuli. We conducted an in silico screen for Cdk5 phosphorylation sites within proteins whose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0223ca25b39fc2cef1d885e32515cc
http://europepmc.org/articles/PMC5775258
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