Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephen J. Mnich"'
Autor:
E. Jon Jacobsen, Matthew J. Saabye, Chun Wang, Jeffrey L. Hirsch, Sheri L. Bonar, Gabriel Mbalaviele, Shaun R. Selness, Hal M. Hoffman, Susan L. Hockerman, Yael Alippe, Joseph B. Monahan, William F. Hood, Stephen J. Mnich, Yousef Abu-Amer, Ariela Haimovich, Heidi R. Hope
Publikováno v:
The Journal of Experimental Medicine
A unique p38α MAPK–MK2 pathway inhibitor, CDD-450, is used to uncover the function of this protein complex in inflammasome priming signals. Importantly, CDD-450 is as efficacious as global p38α MAPK inhibitors in decreasing inflammation in diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531a33bf2ac0ef32007b6033ed6f2f52
https://pubmed.ncbi.nlm.nih.gov/29686326
https://pubmed.ncbi.nlm.nih.gov/29686326
Autor:
Stephen J. Mnich, Olga V. Nemirovskiy, James K. Gierse, Gabriel Mbalaviele, Adele M. Pauley, Alexander F. Shaffer, William M. Moore, Sumathy Mathialagan, Ben S. Zweifel, Jeffrey S. Carter, Jaime L. Masferrer, Michael L. Vazquez, Jane L. Wang
Publikováno v:
Biochemical Pharmacology. 79:1445-1454
Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). The efficacy of nonsteroidal anti-inflammatory drugs and COX-2 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f2b47310c2ae7d1f319e11e57535cc
https://doi.org/10.1016/j.bcp.2010.01.003
https://doi.org/10.1016/j.bcp.2010.01.003
Autor:
Robert J. Mourey, Matthew J. Saabye, Marvin J. Meyers, J. Scott Daniels, William F. Hood, Stephen J. Mnich, Jian Zhang, Jeffrey L. Hirsch, Sarah J. Brustkern, Betsy Pierce, Barry L. Burnette, David R. Anderson, John F. Schindler, Elizabeth G. Webb, Sarah A. South
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:797-807
Activation of the p38 kinase pathway in immune cells leads to the transcriptional and translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated protein kinase 2 (MK2), a direct downstream substrate of p38 kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b053fe059b5214cc7c10c699da95f
https://doi.org/10.1124/jpet.110.166173
https://doi.org/10.1124/jpet.110.166173
Autor:
Jeffrey L. Hirsch, Robert H. Keith, Loreen Stillwell, Pamela De Ciechi, Jian Zhang, Ravi G. Kurumbail, Richard M. Leimgruber, Shaun R. Selness, Huey S. Shieh, Stephen J. Mnich, Yan Zhang, Barry L. Burnette, Michael Hepperle, Robert P. Compton, Raj Devraj, Gail Jungbluth, Win Naing, Joseph B. Monahan, Joseph Portanova, Gary D. Anderson, Heidi R. Hope
Publikováno v:
Pharmacology. 84:42-60
SD0006 is a diarylpyrazole that was prepared as an inhibitor of p38 kinase-alpha (p38alpha). In vitro, SD0006 was selective for p38alpha kinase over 50 other kinases screened (including p38gamma and p38delta with modest selectivity over p38beta). Cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417af8711e84292fd44a13daf8ddc013
https://doi.org/10.1159/000227286
https://doi.org/10.1159/000227286
Autor:
Okechukwu Ukairo, Hidenori Ichijo, Gabriel Mbalaviele, Medora M. Hardy, Joseph B. Monahan, Eric A. Welsh, Alexander F. Shaffer, Chad E. Storer, Liangbiao G. Hu, Patrick M. Blanner, Fernando A. Happa, Stephen J. Mnich, Shawn P. O'Neil, Hiroyuki Eda, Dave Weiss
Publikováno v:
International immunopharmacology. 10(10)
In this report, we show that apoptosis signal-regulating kinase 1(-/-) (ASK1 KO) mice were resistant to inflammatory arthritis induced in the K/BxN serum transfer model of rheumatoid arthritis (RA). The p38 inhibitor, SD-0006 was administered to wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4ba34623e701bb193e08847c7c09d5
https://pubmed.ncbi.nlm.nih.gov/20609399
https://pubmed.ncbi.nlm.nih.gov/20609399
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 333(2)
Antagonists of the cannabinoid receptor 1 (CB 1 ) impart anti-inflammatory activity even though, paradoxically, CB 2 receptors are more predominant on cells of the immune system. We attempted to understand the mechanism of this activity by using an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603550079b8ba7a2c1427215b3232022
https://pubmed.ncbi.nlm.nih.gov/20164299
https://pubmed.ncbi.nlm.nih.gov/20164299
Autor:
W. Rodney Mathews, Olga V. Nemirovskiy, Stephen J. Mnich, Debra M. Meyer, Melissa R. Radabaugh, T. Sunyer, Christie L. Funckes-Shippy, Poonam Aggarwal, Thomas P. Misko
Publikováno v:
Nitric oxide : biology and chemistry. 20(3)
The contribution of inducible nitric oxide synthase (iNOS) to oxidative/nitrative stress is well-documented in inflammation, but difficult to quantify. Using a novel, recently developed assay for 3-nitrotyrosine (3-NT), we characterized iNOS activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0addec7b4276af4379b816cbac0cab41
https://pubmed.ncbi.nlm.nih.gov/19146971
https://pubmed.ncbi.nlm.nih.gov/19146971
Autor:
Ashok S. Naraian, Gunnar J. Hanson, Huey-Sheng Shieh, Richard Weier, Jennifer L. Pawlitz, William C. Stallings, Robert J. Mourey, Joseph B. Monahan, Lifeng Geng, Ravi G. Kurumbail, Jennifer M. Williams, Robert P. Compton, Matthew J. Graneto, Michael L. Vazquez, Koszyk Francis, Rajesh V. Devraj, Xiangdong D. Xu, Gary D. Anderson, Stephen J. Mnich, Michael A. Stealey
Publikováno v:
Journal of medicinal chemistry. 50(23)
A series of pyrazole inhibitors of p38 mitogen-activated protein (MAP) kinase were designed using a binding model based on the crystal structure of 1 (SC-102) bound to p38 enzyme. New chemistry using dithietanes was developed to assemble nitrogen-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43543800b6f9abdb12bc7d1782f4197
https://pubmed.ncbi.nlm.nih.gov/17948975
https://pubmed.ncbi.nlm.nih.gov/17948975
Autor:
Susan A. Gregory, Stephen J. Mnich, Steven W. Kramer, Paul W. Collins, Alan F. Gasiecki, Joseph Portanova
Publikováno v:
American journal of therapeutics. 2(9)
Prostaglandin E(2) (PGE(2)) is known to inhibit in vitro T-cell responses to mitogenic and antigenic stimuli. Interaction of PGE(2) with a G protein-coupled receptor activates adenylyl cyclase, leading to cAMP formation and inhibition of interleukin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305bface098553c71b4f7cfd343195ac
https://pubmed.ncbi.nlm.nih.gov/11854842
https://pubmed.ncbi.nlm.nih.gov/11854842
Autor:
Matthew J. Graneto, Ravi G. Kurumbail, Michael L. Vazquez, Huey-Sheng Shieh, Jennifer L. Pawlitz, Jennifer M. Williams, William C. Stallings, Lifeng Geng, Ashok S. Naraian, Francis J. Koszyk, Michael A. Stealey, Xiangdong D. Xu, Richard M. Weier, Gunnar J. Hanson, Robert J. Mourey, Robert P. Compton, Stephen J. Mnich, Gary D. Anderson, Joseph B. Monahan, Rajesh Devraj
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 23, p5712-5719, 8p