Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stephen J. Kaar"'
Autor:
Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched health
Externí odkaz:
https://doaj.org/article/01e5daca97374a1c9b30a252f899148c
Autor:
Stephen J. Kaar, Ilinca Angelescu, Matthew M. Nour, Tiago Reis Marques, Alice Sharman, Anil Sajjala, John Hutchison, Philip McGuire, Charles Large, Oliver D. Howes
Publikováno v:
Psychopharmacology. 239:3313-3323
The pathophysiology of schizophrenia involves abnormal reward processing, thought to be due to disrupted striatal and dopaminergic function. Consistent with this hypothesis, functional magnetic resonance imaging (fMRI) studies using the monetary ince
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d06b7f969e73a7375699193246d3052
https://doi.org/10.1007/s00213-022-06216-3
https://doi.org/10.1007/s00213-022-06216-3
Autor:
Ilinca Angelescu, Stephen J Kaar, Tiago Reis Marques, Faith Borgan, Mattia Veronesse, Alice Sharman, Anil Sajjala, Bill Deakin, John Hutchison, Charles Large, Oliver D Howes
Publikováno v:
Journal of Psychopharmacology
Background: Current treatments for schizophrenia act directly on dopamine (DA) receptors but are ineffective for many patients, highlighting the need to develop new treatment approaches. Striatal DA dysfunction, indexed using [18F]-FDOPA imaging, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5b831ae657a9288f260cca311bffe
https://doi.org/10.1177/02698811221122031
https://doi.org/10.1177/02698811221122031
Publikováno v:
Clinical EEG and Neuroscience
Impairments in gamma-aminobutyric acid (GABAergic) interneuron function lead to gamma power abnormalities and are thought to underlie symptoms in people with schizophrenia. Voltage-gated potassium 3.1 (Kv3.1) and 3.2 (Kv3.2) channels on GABAergic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0debf44fc33ced7beb5245a4ecb1d3
https://doi.org/10.1177/15500594221148643
https://doi.org/10.1177/15500594221148643
Publikováno v:
Neuroscience and biobehavioral reviews. 132
Schizophrenia is associated with substantial unmet needs, highlighting the necessity for new treatments. This narrative review compares the pharmacology, clinical trial data and tolerability of novel medications to representative antipsychotics. Cari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0e1e304f5d2f14d89749e9df258a6f
https://pubmed.ncbi.nlm.nih.gov/34838528
https://pubmed.ncbi.nlm.nih.gov/34838528
Publikováno v:
BMC Psychiatry, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Psychiatry
BMC Psychiatry
Background Shared decision making is a widely accepted standard of patient-centred care that leads to improved clinical outcomes, yet it is commonly underutilised in the field of mental health. Furthermore, little is known regarding patient decision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4d82654effeea5d6809a18c8eed8cd
http://link.springer.com/article/10.1186/s12888-019-2304-3
http://link.springer.com/article/10.1186/s12888-019-2304-3
Autor:
Toby Pillinger, Stephen J. Kaar, Robert A. McCutcheon, Barbara Santangelo, Federico Turkheimer, Sameer Jauhar, Faith Borgan, Atheeshaan Arumuham, Oliver D. Howes, Katherine Beck, Teresa Sementa, James M. Stone, Colm J. McGinnity, Joel Dunn, Nisha Singh, Alexander Hammers, Mattia Veronese
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched healthy control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e96d067e174367c0c1a1e177b4a2bc
https://pubmed.ncbi.nlm.nih.gov/34385418
https://pubmed.ncbi.nlm.nih.gov/34385418
Publikováno v:
Seminars in Clinical Psychopharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab2dd4e26028fad0eaaf9f3ad1b7aa46
https://doi.org/10.1017/9781911623465.011
https://doi.org/10.1017/9781911623465.011
Autor:
Alexander Hammers, Barbara Santangelo, Katherine Beck, Robert A. McCutcheon, Atheeshaan Arumuham, Colm J. McGinnity, Faith Borgan, Toby Pillinger, Mattia Veronese, Oliver D. Howes, Stephen J. Kaar
Publikováno v:
BJPsych Open
AimsEvidence from genetics, post mortem and animal studies suggest that N-Methyl-D-Aspartate Receptor (NMDAR) hypofunction has an important role in the pathophysiology of psychosis. However, it is not known if NMDAR activity is altered in the early s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ef76be5c31fa2dc1e7d206b5cbc2f
https://doi.org/10.1192/bjo.2021.79
https://doi.org/10.1192/bjo.2021.79
Publikováno v:
Journal of Psychiatric Intensive Care. 13:83-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66cc1990e3c4d95556f31d8942d37136
https://doi.org/10.20299/jpi.2017.007
https://doi.org/10.20299/jpi.2017.007