Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stephen J. Kaar"'
Autor:
Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched health
Externí odkaz:
https://doaj.org/article/01e5daca97374a1c9b30a252f899148c
Autor:
Stephen J. Kaar, Ilinca Angelescu, Matthew M. Nour, Tiago Reis Marques, Alice Sharman, Anil Sajjala, John Hutchison, Philip McGuire, Charles Large, Oliver D. Howes
Publikováno v:
Psychopharmacology. 239:3313-3323
The pathophysiology of schizophrenia involves abnormal reward processing, thought to be due to disrupted striatal and dopaminergic function. Consistent with this hypothesis, functional magnetic resonance imaging (fMRI) studies using the monetary ince
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d06b7f969e73a7375699193246d3052
https://doi.org/10.1007/s00213-022-06216-3
https://doi.org/10.1007/s00213-022-06216-3
Autor:
Ilinca Angelescu, Stephen J Kaar, Tiago Reis Marques, Faith Borgan, Mattia Veronesse, Alice Sharman, Anil Sajjala, Bill Deakin, John Hutchison, Charles Large, Oliver D Howes
Publikováno v:
Journal of Psychopharmacology
Background: Current treatments for schizophrenia act directly on dopamine (DA) receptors but are ineffective for many patients, highlighting the need to develop new treatment approaches. Striatal DA dysfunction, indexed using [18F]-FDOPA imaging, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5b831ae657a9288f260cca311bffe
https://doi.org/10.1177/02698811221122031
https://doi.org/10.1177/02698811221122031
Publikováno v:
Clinical EEG and Neuroscience
Impairments in gamma-aminobutyric acid (GABAergic) interneuron function lead to gamma power abnormalities and are thought to underlie symptoms in people with schizophrenia. Voltage-gated potassium 3.1 (Kv3.1) and 3.2 (Kv3.2) channels on GABAergic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0debf44fc33ced7beb5245a4ecb1d3
https://doi.org/10.1177/15500594221148643
https://doi.org/10.1177/15500594221148643
Publikováno v:
BMC Psychiatry, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Psychiatry
BMC Psychiatry
Background Shared decision making is a widely accepted standard of patient-centred care that leads to improved clinical outcomes, yet it is commonly underutilised in the field of mental health. Furthermore, little is known regarding patient decision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4d82654effeea5d6809a18c8eed8cd
http://link.springer.com/article/10.1186/s12888-019-2304-3
http://link.springer.com/article/10.1186/s12888-019-2304-3
Autor:
Alexander Hammers, Barbara Santangelo, Katherine Beck, Robert A. McCutcheon, Atheeshaan Arumuham, Colm J. McGinnity, Faith Borgan, Toby Pillinger, Mattia Veronese, Oliver D. Howes, Stephen J. Kaar
Publikováno v:
BJPsych Open
AimsEvidence from genetics, post mortem and animal studies suggest that N-Methyl-D-Aspartate Receptor (NMDAR) hypofunction has an important role in the pathophysiology of psychosis. However, it is not known if NMDAR activity is altered in the early s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ef76be5c31fa2dc1e7d206b5cbc2f
https://doi.org/10.1192/bjo.2021.79
https://doi.org/10.1192/bjo.2021.79
Publikováno v:
Journal of Psychiatric Intensive Care. 13:83-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66cc1990e3c4d95556f31d8942d37136
https://doi.org/10.20299/jpi.2017.007
https://doi.org/10.20299/jpi.2017.007
Autor:
Oliver D. Howes, Frans van den Berg, Stephen J. Kaar, John Hutchison, Tiago Reis Marques, Charles H. Large
BACKGROUND: Fast-spiking, parvalbumin-positive GABAergic interneurons in corticolimbic circuits modulate the synchronous firing of pyramidal neurons to enhance gamma-frequency oscillations which are thought to underpin cognitive function. Increasing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dfc2bf834077b753b35737bcdf1889
https://europepmc.org/articles/PMC6455279/
https://europepmc.org/articles/PMC6455279/
Publikováno v:
BMJ (Clinical research ed.). 364
What you need to know You are urgently called to reception where a 25 year old man is shouting about the building having been taken over by demons. He appears distressed and is not responding to attempts by reception staff to communicate with him. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be02647211e645a904b25402253cceb0
https://pubmed.ncbi.nlm.nih.gov/30846425
https://pubmed.ncbi.nlm.nih.gov/30846425
Publikováno v:
Neuropharmacology. 172
Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic disorders but are ineffective for some patients and associated with side-effects and nonadherence in others. We review the in vitro, pre-clinical, clinical and mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318b525f521da11da85b984f1bad9fcb
https://pubmed.ncbi.nlm.nih.gov/31299229
https://pubmed.ncbi.nlm.nih.gov/31299229