Zobrazeno 1 - 10
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pro vyhledávání: '"Stephen J. Gaunt"'
Autor:
Stephen J. Gaunt
Publikováno v:
Journal of Developmental Biology, Vol 10, Iss 4, p 48 (2022)
The Hox gene cluster, responsible for patterning of the head–tail axis, is an ancestral feature of all bilaterally symmetrical animals (the Bilateria) that remains intact in a wide range of species. We can say that the Hox cluster evolved successfu
Externí odkaz:
https://doaj.org/article/1691d83a2c364978bda7d350699a7052
Autor:
Yu-Lee Paul, Stephen J. Gaunt
Publikováno v:
Biology, Vol 1, Iss 3, Pp 557-574 (2012)
How have animals evolved new body designs (morphological evolution)? This requires explanations both for simple morphological changes, such as differences in pigmentation and hair patterns between different Drosophila populations and species, and als
Externí odkaz:
https://doaj.org/article/2e4fdce57c554f02afe9929a15ead04e
Autor:
Stephen J. Gaunt
Publikováno v:
The International Journal of Developmental Biology. 62:673-683
The discovery of Hox gene clusters, first in Drosophila (a protostome) and then as homologues in vertebrates (deuterostomes), was a major step in our understanding of both developmental and evolutionary biology. Hox genes in both species perform the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdb1d703866409a292c8fcb11c17ff3
https://doi.org/10.1387/ijdb.180162sg
https://doi.org/10.1387/ijdb.180162sg
Gdf11/Smad signalling and Cdx proteins cooperate to activate the Hoxc8 early enhancer in HepG2 cells
Autor:
Stephen J. Gaunt
Publikováno v:
The International Journal of Developmental Biology. 61:427-432
Developing anatomy along the head-tail axis of bilaterian embryos is specified, to a large extent, by the overlapping patterns of expression of the Hox genes. Hox gene enhancers respond to a variety of signals in order to regulate these discreet doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dfec684cf032d16dde453918e5e8ab
https://doi.org/10.1387/ijdb.170066sg
https://doi.org/10.1387/ijdb.170066sg
Autor:
Stephen J. Gaunt
Publikováno v:
The International journal of developmental biology. 62(11-12)
Mouse Hox gene enhancer elements have typically been identified and characterized using Hox/lacZ transgenic mouse embryos. Such studies have, for example, identified Cdx responsive binding motifs in the enhancers of Hoxb8 and Hoxa7. Production of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837fd4db500fd1af1192999515fc8fa8
https://pubmed.ncbi.nlm.nih.gov/30604841
https://pubmed.ncbi.nlm.nih.gov/30604841
Autor:
Stephen J. Gaunt
Publikováno v:
The International Journal of Developmental Biology. 59:159-170
Arthropods and vertebrates inherited their Hox clusters from an ancestral cluster of at least six genes already present in their last common ancestor, Urbilateria. Clustering and a common transcriptional direction are both likely features of the way
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d02bbc1b2c0163cda10d00bd1b650f
https://doi.org/10.1387/ijdb.150223sg
https://doi.org/10.1387/ijdb.150223sg
Publikováno v:
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 322:631-642
We provide novel data on vertebral ontogeny in the mouse, the mammalian model-of-choice for developmental studies. Most previous studies on ossification sequences in mice have focused on pooled elements of the spine (cervicals, thoracics, lumbars, sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51cb22ee5ceadd0e8649f74d96f861b3
https://doi.org/10.1002/jez.b.22590
https://doi.org/10.1002/jez.b.22590
Autor:
Yu-Lee Paul, Stephen J. Gaunt
Publikováno v:
The International Journal of Developmental Biology. 55:93-98
Cdx1, an upstream regulator of Hox genes, is best characterized for its homeotic effects upon the developing axial skeleton, particularly in the neck. It responds to retinoic acid (RA) in both mouse embryos and embryonal carcinoma (EC) cells. By use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388c50c7aa9d69bb5ce1141be25d8759
https://doi.org/10.1387/ijdb.103252sg
https://doi.org/10.1387/ijdb.103252sg
Autor:
Martin McMahon, Stephen J. Gaunt, Simon J. Cook, Zofia E. Madeja, Myriam Hemberger, Felix Krueger
Publikováno v:
Cellular Signalling. 21:1846-1856
Cdx2 is a homeodomain transcription factor that regulates normal intestinal cell differentiation. Cdx2 is frequently lost during progression of colorectal cancer (CRC) and is widely viewed as a colorectal tumour suppressor. A previous study suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f1037995eccde47a2141c3b81731f9
https://doi.org/10.1016/j.cellsig.2009.07.020
https://doi.org/10.1016/j.cellsig.2009.07.020
Publikováno v:
Development. 135:2511-2520
To investigate the link between Cdx protein concentration and axial patterning in embryos, we made lines of mice OE1, OE2 and OE4 that overexpress each of the Cdx genes Cdx1, Cdx2 and Cdx4,respectively. The lines carry Cdx transgenes under the transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db39b84fb00f896a3ea291c4f26d59a7
https://doi.org/10.1242/dev.015909
https://doi.org/10.1242/dev.015909