Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Stephen J. Fuller"'
Autor:
Johanna Guggemos, Stephen J. Fuller, Kristen K. Skarratt, Benjamin Mayer, E. Marion Schneider
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionExtracellular ATP (eATP) released from damaged cells activates the P2X7 receptor (P2X7R) ion channel on the surface of surrounding cells, resulting in calcium influx, potassium efflux and inflammasome activation. Inherited changes in the
Externí odkaz:
https://doaj.org/article/0900d2593e4744e3aca82b754934bfd9
Publikováno v:
Oncology and Therapy, Vol 11, Iss 1, Pp 27-48 (2022)
Abstract Introduction Tumor-associated macrophages (TAMs) in breast cancer are associated with a poor prognosis. Early studies of TAMs were largely limited to the pan-macrophage marker CD68, however, more recently, an increasing number of studies hav
Externí odkaz:
https://doaj.org/article/5d35c2c56c974754a1f7a72295760e91
Autor:
Ronald Sluyter, Sahil Adriouch, Stephen J. Fuller, Annette Nicke, Reece A. Sophocleous, Debbie Watson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8225 (2023)
The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of P2X7 and helped to establish the numerous physiological and pathophysio
Externí odkaz:
https://doaj.org/article/c438b8e4d86c48c8b331049e80db42fc
Autor:
Sophie K. F. De Salis, Lanxin Li, Zheng Chen, Kam Wa Lam, Kristen K. Skarratt, Thomas Balle, Stephen J. Fuller
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8174 (2022)
The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad range of cellular responses including cytokine and chemokine release, cell
Externí odkaz:
https://doaj.org/article/c6d721797ae74371b9ffe22eb4cfe700
Autor:
Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Katrina M. Bird, Stephen J. Fuller, Debbie Watson, Ronald Sluyter
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8343 (2021)
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for blood cancers and other haematological disorders. However, allo-HSCT leads to graft-versus-host disease (GVHD), a severe and often lethal immunological response
Externí odkaz:
https://doaj.org/article/b157e75c42804025b0a9082405506fcf
Publikováno v:
Australian Journal of Rural Health. 31:336-338
Autor:
Kristy P. Robledo, Benjamin Tang, Stephen J. Fuller, Kristen K. Skarratt, Maryam Hassanvand, Abdullah Alshahrani
Publikováno v:
Oncology and Therapy
Introduction People with a family history of chronic lymphocytic leukemia (F-CLL) have an increased risk of monoclonal B lymphocytosis (F-MBL), which is found in up to 18% of first-degree relatives of patients compared to 5% of the total population.
Autor:
Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Cardiac hypertrophy is necessary for the heart to accommodate an increase in workload. Physiological, compensated hypertrophy (e.g. with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hyperte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac2dcbbe2f252857669529379968100
https://doi.org/10.1101/2022.09.07.506723
https://doi.org/10.1101/2022.09.07.506723
Autor:
Puja Bhattacharyya, Richard I. Christopherson, Kristen K. Skarratt, Jake Z. Chen, Thomas Balle, Stephen J. Fuller
Publikováno v:
Cancers. 15:2881
B cells are central to the adaptive immune response, providing long lasting immunity after infection. B cell activation is mediated by a cell surface B cell receptor (BCR) following recognition of an antigen. BCR signaling is modulated by several co-
Autor:
Leanne Stokes, Rachel Glover, Michael D. Lovelace, Steven Petrou, Ben J. Gu, James S. Wiley, Carol J. Milligan, Kristen K. Skarratt, Stephen J. Fuller
Publikováno v:
The FASEB Journal. 34:3884-3901
P2X7 is an ATP-gated membrane ion channel that is expressed by multiple cell types. Brief exposure to ATP induces the opening of a nonselective cation channel; while repeated or prolonged exposure induces formation of a transmembrane pore. This proce