Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Stephen J. Dunsdon"'
Autor:
David J. Bushnell, Joseph A. Martin, Michelle P. Gunn, Stephen J. Dunsdon, Robert W. Lambert, Kevin E. B. Parkes, Andrew C. Freeman, Richard A. Hopkins, Peter H. Crackett
Publikováno v:
The Journal of Organic Chemistry. 59:3656-3664
Ro 31-8959 (1), a potent and selective inhibitor of HIV proteinase, is currently in phase III clinical trials. Six approaches for the large-scale synthesis of this compound have been studied. All routes employ an initial disconnection to an electroph
Autor:
Christopher Higgs, Wiesia Maniara, Neil Victor Harris, Sussie L. Krintel, Kenji Namoto, Alokesh Duttaroy, Finton Sirockin, Christopher A. Hurley, Nils Ostermann, Daniel K. Baeschlin, Robert Edward Mackenzie, Eric Gangl, David E. Clark, Garry Fenton, Jörg Trappe, Amanda Fillmore, Ulrich Hassiepen, Stephen J. Dunsdon, Jon Sutton, Richard Sedrani, Bernd Gerhartz
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Novel deazaxanthine-based DPP-4 inhibitors have been identified that are potent (IC(50)10nM) and highly selective versus other dipeptidyl peptidases. Their synthesis and SAR are reported, along with initial efforts to improve the PK profile through d
Autor:
K. E. B. Parkes, D. J. Bushnell, S. A. Galpin, I. B. Duncan, Martin Joseph Armstrong, Stephen J. Dunsdon, M. J. Hall, P. J. Machin, NA Roberts, G. J. Thomas, J. H. Merrett, D. Kinchington
Publikováno v:
ChemInform. 22
Autor:
M. P. Gunn, J. H. Merrett, Stephen J. Dunsdon, A. C. Freeman, W. C. Spurden, Martin Joseph Armstrong, G. J. Thomas, R. A. Hopkins, S. Redshaw, Robert W. Lambert, D. J. Bushnell, K. E. B. Parkes, P. H. Crackett
Publikováno v:
ChemInform. 25
Autor:
Kevin E. B. Parkes, David J. Bushnell, Philippe Wong Kai-In, Andrew C. Freeman, Julie E Cansfield, JH Merrett, Ian R Johns, Stephen J. Dunsdon, Stewart J. Baker, Joseph Armstrong Martin, Mark Holland, Heather Simmonite, Andrea Walmsley, Robert Wilson Lambert, Gareth John Thomas, Elizabeth Keech, Richard A. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A series of carboxamide derivatives of 5′-amino-2′,5′-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthra
Autor:
Christopher A. Hurley, Robert Edward Mackenzie, Christopher Higgs, David E. Clark, Richard Sedrani, Nils Ostermann, Stephen J. Dunsdon, Sussie L. Krintel, Bernd Gerhartz, Neil Victor Harris, Daniel K. Baeschlin, Jon Sutton, Jörg Trappe, Wiesia Maniara, Kenji Namoto, Finton Sirockin, Eric Gangl, Garry Fenton, Amanda Fillmore, Ulrich Hassiepen, Alokesh Duttaroy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2359
Publikováno v:
Tetrahedron. 41:2919-2922
The structures of doxepin and serotonin were overlayed using molecular graphics and 1 - [2-(dimethylamino)ethyl] - 7, 12 - dihydro - 3H - [2] - benzoxepino[4,3-e]indole(1) was proposed as a potential antidepressant agent. This paper deals with the sy
Publikováno v:
Chemischer Informationsdienst. 16