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pro vyhledávání: '"Stephen J. Chawner"'
Autor:
Henriëtte M. G. Willems, Simon Edwards, Helen K. Boffey, Stephen J. Chawner, Christopher Green, Tamara Romero, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews
The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating cell signalling pathways and, as such, have become therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders. Many of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f8b2006fdb5bab4230b8704b380df0
Autor:
Timothy P. C. Rooney, Gregory G. Aldred, Helen K. Boffey, Henriëtte M. G. Willems, Simon Edwards, Stephen J. Chawner, Duncan E. Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews
Owing to their central role in regulating cell signaling pathways, the phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive therapeutic targets in diseases such as cancer, neurodegeneration, and immunological disorders. Until now, tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d160b7c900b0f29940d1fd8d175c7fc
Publikováno v:
European Journal of Organic Chemistry
Cyclopropanes provide important design elements in medicinal chemistry and are widely present in drug compounds. Here we describe a strategy and extensive synthetic studies for the preparation of a diverse collection of cyclopropane‐containing lead