Zobrazeno 1 - 10 of 355 pro vyhledávání: '"Stephen J Walsh"'
1
Akademický článek
Novel immunotherapeutics against LGR5 to target multiple cancer types
Autor: Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz: https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
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2
Akademický článek
Automatic Assessment of Intelligibility in Noise in Parkinson Disease: Validation Study
Autor: Gemma Moya-Galé, Stephen J Walsh, Alireza Goudarzi
Publikováno v: Journal of Medical Internet Research, Vol 24, Iss 10, p e40567 (2022)
BackgroundMost individuals with Parkinson disease (PD) experience a degradation in their speech intelligibility. Research on the use of automatic speech recognition (ASR) to assess intelligibility is still sparse, especially when trying to replicate
Externí odkaz: https://doaj.org/article/c3da14b034544e99b26a6bc58cd4621f
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3
Peroxide-cleavable linkers for antibody–drug conjugates
Autor: Nicola Ashman, Jonathan D. Bargh, Stephen J. Walsh, Ryan D. Greenwood, Arnaud Tiberghien, Jason S. Carroll, David R. Spring
Publikováno v: Chemical Communications. 59:1841-1844
Peroxide-cleavable arylboronates are stable linkers for the generation of efficacious antibody–drug conjugates.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9f9bb185a2b76852b31e7cfcda309ac
https://doi.org/10.1039/d2cc06677g
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4
Akademický článek
Assessing Deep Convolutional Neural Networks and Assisted Machine Perception for Urban Mapping
Autor: Yang Shao, Austin J. Cooner, Stephen J. Walsh
Publikováno v: Remote Sensing, Vol 13, Iss 8, p 1523 (2021)
High-spatial-resolution satellite imagery has been widely applied for detailed urban mapping. Recently, deep convolutional neural networks (DCNNs) have shown promise in certain remote sensing applications, but they are still relatively new techniques
Externí odkaz: https://doaj.org/article/b95ef8c8527348b297698a782341dda1
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7
A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
Autor: Teodors Pantelejevs, Pedro Zuazua-Villar, Oliwia Koczy, Andrew Counsell, Stephen J. Walsh, Naomi S. Robertson, David R. Spring, Jessica Downs, Marko Hyvönen
Stapling is a macrocyclisation method that connects amino acid side chains of a peptide to improve its pharmacological properties. We describe an approach for stapled peptide preparation and biochemical evaluation that combines recombinant expression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8c0b33c447ad7c67122ecea5501718c
https://doi.org/10.1101/2023.02.24.529929
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