Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Stephen J Ryan"'
Autor:
Parameswaran G Sreekumar, Christine Spee, Stephen J Ryan, Susan P C Cole, Ram Kannan, David R Hinton
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33420 (2012)
Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis that the protective effect of α-crystallin is mediated by changes in cellular glutathi
Externí odkaz:
https://doaj.org/article/322fccd70f4c4e4c91e0bbbe39ccaacb
Autor:
Parameswaran G Sreekumar, Ram Kannan, Mizuki Kitamura, Christine Spee, Ernesto Barron, Stephen J Ryan, David R Hinton
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e12578 (2010)
αB crystallin is a chaperone protein with anti-apoptotic and anti-inflammatory functions and has been identified as a biomarker in age-related macular degeneration. The purpose of this study was to determine whether αB crystallin is secreted from r
Externí odkaz:
https://doaj.org/article/abae292a0023439cb331d940bb7b2b15
Autor:
Melody, Ryan, Stephen J, Ryan
Publikováno v:
The American journal of managed care. 24
First described almost 50 years ago, chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disorder characterized by progressive peripheral neuropathy. CIDP is difficult to diagnose, but early diagnosis can be crucial to preve
Autor:
David R. Hinton, Ram Kannan, Stephen J. Ryan, Parameswaran G. Sreekumar, Guorui Dou, Shikun He, Christine Spee
Publikováno v:
Free Radical Biology and Medicine. 53:1111-1122
Endoplasmic reticulum (ER) stress is linked to several pathological conditions including age-related macular degeneration. Excessive ER stress initiates cell death cascades which are mediated, in part, through mitochondrial dysfunction. Here, we iden
Autor:
Shikun He, David R. Hinton, Mizuki Kitamura, Ram Kannan, Satoru Kase, Christine Spee, Stephen J. Ryan, Eric F. Wawrousek, Shozo Sonoda
Publikováno v:
Blood. 115:3398-3406
alphaB-crystallin is a chaperone belonging to the small heat shock protein family. Herein we show attenuation of intraocular angiogenesis in alphaB-crystallin knockout (alphaB-crystallin(-/-)) mice in 2 models of intraocular disease: oxygen-induced r
Autor:
N. Zhang, David R. Hinton, Christine Spee, Ram Kannan, Jiehao Zhou, Shikun He, Peng Zhou, Stephen J. Ryan
Publikováno v:
Journal of Biomedicine and Biotechnology, Vol 2010 (2010)
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology
We hypothesized that neutrophils and their secreted factors mediate breakdown of the integrity of the outer blood-retina-barrier by degrading the apical tight junctions of the retinal pigment epithelium (RPE). The effect of activated neutrophils or n
Publikováno v:
Nature Protocols. 4:662-673
We provide our detailed, standardized in vitro protocol for the culture and differentiation of human retinal pigment epithelial (RPE) cells into a highly polarized and functional monolayer. Disruption of the polarized RPE function plays an important
Publikováno v:
Experimental Eye Research. 88:410-417
The purpose of this study was to determine the expression, regulation and signaling of a key redoxin family member thioredoxin 1 (Trx1) in normal, oxidant-stimulated and growth factor-pretreated RPE cells. Trx1 is expressed in early passage, human RP
Publikováno v:
Clinical Neurology and Neurosurgery. 110:451-454
Objectives To determine the safety of telephonic guidance for use of intravenous recombinant tissue plasminogen activator (IV rtPA) in rural hospitals. Patients and methods We performed a retrospective survey of 123 consecutive patients treated with
Autor:
Stephen J. Ryan, Philip E. Cleary
We have developed a reproducible model of traction retinal detachment in the rhesus monkey secondary to a penetrating eye injury. The model is characterized histologically by intravitreal fibroblastic proliferation and by epiretinal and by retroretin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5311345d7deaea6aa15f011fe6ef69
https://doi.org/10.1159/000395342
https://doi.org/10.1159/000395342