Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Stephen J Moss"'
Autor:
Jayashree Chadchankar, Victoria Korboukh, Leslie C Conway, Heike J Wobst, Chandler A Walker, Peter Doig, Steve J Jacobsen, Nicholas J Brandon, Stephen J Moss, Qi Wang
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225145 (2019)
USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has been considered a therapeutic strategy for accelerating degradation of aggr
Externí odkaz:
https://doaj.org/article/c60ec594d4014be88866d863ddbc6e21
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177181 (2017)
The RNA-binding and -processing protein TAR DNA-binding protein 43 (TDP-43) is heavily linked to the underlying causes and pathology of neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these d
Externí odkaz:
https://doaj.org/article/254ae68e506d4436b553113c9b2e51cc
Autor:
Kendall R Walker, Amit Modgil, David Albrecht, Selene Lomoio, Philip G Haydon, Stephen J Moss, Giuseppina Tesco
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155799 (2016)
Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) is a monomeric clathrin adaptor that has been shown to regulate the trafficking of the Beta-site APP-cleaving enzyme (BACE1), which is required for production of the Alzheimer's disease (
Externí odkaz:
https://doaj.org/article/f97a36937c584f06ae853a52e5cb0fbf
Autor:
Gábor M. Mórotz, Neil A. Bradbury, Oana Caluseriu, Shin-ichi Hisanaga, Christopher C. J. Miller, Agnieszka Swiatecka-Urban, Heinz-Josef Lenz, Stephen J. Moss, Georgios Giamas
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-5 (2024)
Abstract The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including regulation of axonal transport and endosomal trafficking, modulation of synaptic functions, memory
Externí odkaz:
https://doaj.org/article/dc1232efb3394a418b23d97959fbfedf
Autor:
Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109512- (2024)
Summary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is u
Externí odkaz:
https://doaj.org/article/fe648812ed2245d28cd51d531ae0f3c3
Autor:
Verena Tretter, Stephen J Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 1 (2008)
GABA A receptors are located on the majority of neurons in the central and peripheral nervous system, where they mediate important actions of the neurotransmitter gamma-aminobutyric acid. Early in development the trophic properties of GABA allow a he
Externí odkaz:
https://doaj.org/article/9ba76bdc3b28401787e2642d44cdf811
Autor:
Stephen J Moss
Publikováno v:
Contemporary Clinical Dentistry, Vol 1, Iss 4, Pp 208-209 (2010)
Externí odkaz:
https://doaj.org/article/30796b95839e45dbbb61f7eacf54c918
Autor:
Joshua L. Smalley, Noell Cho, Shu Fun Josephine Ng, Catherine Choi, Abigail H. S. Lemons, Saad Chaudry, Christopher E. Bope, Jake S. Dengler, Chuansheng Zhang, Matthew N. Rasband, Paul A. Davies, Stephen J. Moss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The subunit composition of GABAA receptors and their interaction with beta spectrin complexes influences their localization between the neuronal axon initial segment or dendrites.
Externí odkaz:
https://doaj.org/article/edfc1bb22db642f7ab73e66911075353
Autor:
Catherine Choi, Joshua L. Smalley, Abigail H. S. Lemons, Qiu Ren, Christopher E. Bope, Jake S. Dengler, Paul A. Davies, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience. 15
Impaired inhibitory signaling underlies the pathophysiology of many neuropsychiatric and neurodevelopmental disorders including autism spectrum disorders and epilepsy. Neuronal inhibition is regulated by synaptic and extrasynaptic γ-aminobutyric aci