Zobrazeno 1 - 10
of 395
pro vyhledávání: '"Stephen J Meltzer"'
Autor:
Yunke Song, Duncan Kilburn, Jee Hoon Song, Yulan Cheng, Christopher T Saeui, Douglas G Cheung, Carlo M Croce, Kevin J Yarema, Stephen J Meltzer, Kelvin J Liu, Tza-Huei Wang
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180988 (2017)
Accurate measurement of miRNA expression is critical to understanding their role in gene expression as well as their application as disease biomarkers. Correct identification of changes in miRNA expression rests on reliable normalization to account f
Externí odkaz:
https://doaj.org/article/a94eaca396c447fa8071bc2f22837837
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169691 (2017)
Proton pump inhibitors (PPIs) have been used for treatment of Barrett's esophagus (BE) for many years. However, the connection between PPIs and esophageal adenocarcinoma (EAC) in patients with BE has still been controversial. The current systematic r
Externí odkaz:
https://doaj.org/article/cde4628a599c48c18c01675d3ebb086f
Autor:
Yulan Cheng, Ana P Kiess, Joseph M Herman, Martin G Pomper, Stephen J Meltzer, John M Abraham
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128152 (2015)
Radioisotopes that emit electrons (beta particles), such as radioiodine, can effectively kill target cells, including cancer cells. Aqueous 32P[PO4] is a pure beta-emitter that has been used for several decades to treat non-malignant human myeloproli
Externí odkaz:
https://doaj.org/article/69cdc6cb840d403184553bc730760a83
Autor:
Surbhi Jain, Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin, Chi-Tan Hu, Batbold Boldbaatar, James P Hamilton, Selena Y Lin, Ting-Tsung Chang, Shun-Hua Chen, Wei Song, Stephen J Meltzer, Timothy M Block, Ying-Hsiu Su
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35789 (2012)
Hypermethylation of the glutathione S-transferase π 1 (GSTP1) gene promoter region has been reported to be a potential biomarker to distinguish hepatocellular carcinoma (HCC) from other liver diseases. However, reports regarding how specific a marke
Externí odkaz:
https://doaj.org/article/8157d69ee3964b4d8dbef3aed7b088c5
Autor:
Hector Alvarez, Joanna Opalinska, Li Zhou, Davendra Sohal, Melissa J Fazzari, Yiting Yu, Christina Montagna, Elizabeth A Montgomery, Marcia Canto, Kerry B Dunbar, Jean Wang, Juan Carlos Roa, Yongkai Mo, Tushar Bhagat, K H Ramesh, Linda Cannizzaro, J Mollenhauer, Reid F Thompson, Masako Suzuki, Stephen J Meltzer, Ari Melnick, John M Greally, Anirban Maitra, Amit Verma
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001356 (2011)
Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unk
Externí odkaz:
https://doaj.org/article/6a4dfe7d74b147538ce4d65d3a9a0ab9
Autor:
Surbhi Jain, Ting-Tsung Chang, James P Hamilton, Selena Y Lin, Yih-Jyh Lin, Alison A Evans, Florin M Selaru, Pin-Wen Lin, Shun-Hua Chen, Timothy M Block, Chi-Tan Hu, Wei Song, Stephen J Meltzer, Ying-Hsiu Su
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26799 (2011)
Hypermethylation of the promoter of the tumor suppressor gene, adenomatous polyposis coli (APC), occurs in various malignancies, including hepatocellular carcinoma (HCC). However, reports on the specificity of the methylation of the APC gene for HCC
Externí odkaz:
https://doaj.org/article/96e2199a4fe045fe8a6c5b2bad2d09fb
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7715 (2009)
BackgroundCoding region microsatellite instability (MSI) results in loss of gene products and promotion of microsatellite-unstable (MSI-H) carcinogenesis. Recent studies have indicated that MSI within 3'-untranslated regions (3'UTRs) may post-transcr
Externí odkaz:
https://doaj.org/article/576e470d9b5e4cc4bd997916c221ac2c
Autor:
Rachana Agarwal, Yuriko Mori, Yulan Cheng, Zhe Jin, Alexandru V Olaru, James P Hamilton, Stefan David, Florin M Selaru, Jian Yang, John M Abraham, Elizabeth Montgomery, Patrice J Morin, Stephen J Meltzer
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8002 (2009)
Claudins are membrane proteins that play critical roles in tight junction (TJ) formation and function. Members of the claudin gene family have been demonstrated to be aberrantly regulated, and to participate in the pathogenesis of various human cance
Externí odkaz:
https://doaj.org/article/1ff85d7b6f96494baa02925f27c4c7de
Autor:
John M Abraham, Yulan Cheng, James P Hamilton, Bogdan Paun, Zhe Jin, Rachana Agarwal, Takatsugu Kan, Stefan David, Alexandru Olaru, Jian Yang, Tetsuo Ito, Florin M Selaru, Yuriko Mori, Stephen J Meltzer
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2508 (2008)
Cancers have been revealed to be extremely heterogenous in terms of the frequency and types of mutations present in cells from different malignant tumors. Thus, it is likely that uniform clinical treatment is not optimal for all patients, and that th
Externí odkaz:
https://doaj.org/article/7e4e0408aa8547bd9afe8634bc07a6a5
Autor:
Fumiaki Sato, Zhe Jin, Karsten Schulmann, Jean Wang, Bruce D Greenwald, Tetsuo Ito, Takatsugu Kan, James P Hamilton, Jian Yang, Bogdan Paun, Stefan David, Alexandru Olaru, Yulan Cheng, Yuriko Mori, John M Abraham, Harris G Yfantis, Tsung-Teh Wu, Mary B Fredericksen, Kenneth K Wang, Marcia Canto, Yvonne Romero, Ziding Feng, Stephen J Meltzer
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1890 (2008)
Barrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's esophagus has been debated because of the low incidence of esophageal adenocarcinoma in Barrett's esophagus. Moreover, high inter
Externí odkaz:
https://doaj.org/article/448f834db6b2493aa69544cf81f2acc2