Výsledky vyhledávání - "Stephen J McNally"

Early goal-directed therapy: can the emergency department deliver?

Autor: Richard Lyon, Martin Hawkins, Marian MacKinnon, Stephen J McNally

Publikováno v: Emergency medicine journal : EMJ. 27(5)

Background Early goal-directed therapy (EGDT) has been shown to improve outcome in patients presenting to the emergency department (ED). Uptake of EGDT in EDs in the UK has been slow. Objective To establish the level of awareness and skills necessary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c414d755ab2dda9039b0074611bf72fb
https://pubmed.ncbi.nlm.nih.gov/20961940

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De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1

Autor: Stephen J, Wigmore, Kathryn, Sangster, Stephen J, McNally, Ewen M, Harrison, James A, Ross, Kenneth C H, Fearon, O James, Garden

Publikováno v: International journal of molecular medicine. 19(3)

Expression of inducible heat shock protein (HSP70) requires activation of heat shock transcription factor-1 (HSF-1). Recent evidence suggests that interleukin-6 (IL-6) can modify the response of HSF-1 to heat. We hypothesized that IL-6 would prime th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b56f744026719c6a1b3d149b2bb5ef5
https://pubmed.ncbi.nlm.nih.gov/17273789

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Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition

Autor: Stephen J, McNally, Ewen M, Harrison, James A, Ross, O James, Garden, Stephen J, Wigmore

Publikováno v: International journal of molecular medicine. 19(1)

Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated. This study investigates in detail the mechanism of HO-1 induction by curcumin in human hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee8da10d6d0c42c903da27247b6745d2
https://pubmed.ncbi.nlm.nih.gov/17143561

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Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells

Autor: Ewen M, Harrison, Stephen J, McNally, Luke, Devey, O J, Garden, James A, Ross, Stephen J, Wigmore

Publikováno v: The FEBS journal. 273(11)

Heme oxygenase-1 catalyzes the breakdown of heme and is protective in models of kidney transplantation. In this study we describe the induction of heme oxygenase-1 mRNA and protein by insulin. Following treatment with insulin, a five-fold increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60996ed8f36760af5ecbff4f67bdb440
https://pubmed.ncbi.nlm.nih.gov/16704410

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