Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Stephen J Lewis"'
Autor:
Eduardo Reyes-Serratos, Joy Ramielle L Santos, Lakshmi Puttagunta, Stephen J Lewis, Mechiko Watanabe, Aron Gonshor, Robert Buck, A Dean Befus, Marcelo Marcet-Palacios
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0301855 (2024)
Calcium binding protein, spermatid associated 1 (CABS1) is a protein most widely studied in spermatogenesis. However, mRNA for CABS1 has been found in numerous tissues, albeit with little information about the protein. Previously, we identified CABS1
Externí odkaz:
https://doaj.org/article/93823a0893ba437b96f7bada08bfc7aa
Autor:
James M Seckler, Nikki M Meyer, Spencer T Burton, James N Bates, Benjamin Gaston, Stephen J Lewis
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187149 (2017)
Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these mole
Externí odkaz:
https://doaj.org/article/c4ec4f213c964ba39adb53a95d6dab6c
Autor:
Ibrahim M. Salman, Omar Z. Ameer, Sheridan McMurray, Sarah F. Hassan, Arun Sridhar, Stephen J. Lewis, Yee-Hsee Hsieh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Carotid baroreceptor stimulation has been clinically explored for antihypertensive benefits, but neuromodulation of aortic baroreceptor afferents remains unexplored for potential translation into the clinic. Published studies have used supra
Externí odkaz:
https://doaj.org/article/8f7b622d5f594dc7aa80a93c96e892db
Autor:
Jiansong Fang, Pengyue Zhang, Quan Wang, Chien-Wei Chiang, Yadi Zhou, Yuan Hou, Jielin Xu, Rui Chen, Bin Zhang, Stephen J. Lewis, James B. Leverenz, Andrew A. Pieper, Bingshan Li, Lang Li, Jeffrey Cummings, Feixiong Cheng
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-23 (2022)
Abstract Background Genome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer’s disease (AD). However, utilizing GWAS and multi-omics data to identify high-confidence AD risk genes (ARGs) and druggable target
Externí odkaz:
https://doaj.org/article/afadea9add5a4dca9d53dbb246f34925
Autor:
Tristan H.J. Lewis, Walter J. May, Alex P. Young, James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Rita M. Ryan, Yee-Hsee Hsieh, James M. Seckler, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113939- (2022)
This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in frequency of breathing, expiratory time, tidal volume, minute v
Externí odkaz:
https://doaj.org/article/e97d1f8b74384e33b9624693da14c584
Autor:
Paulina M. Getsy, Sripriya Sundararajan, Walter J. May, Graham C. von Schill, Dylan K. McLaughlin, Lisa A. Palmer, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract The roles of endothelial nitric oxide synthase (eNOS) in the ventilatory responses during and after a hypercapnic gas challenge (HCC, 5% CO2, 21% O2, 74% N2) were assessed in freely-moving female and male wild-type (WT) C57BL6 mice and eNOS
Externí odkaz:
https://doaj.org/article/83b2cc0829054a62817de19918ed5a05
Autor:
Paulina M. Getsy, Sripriya Sundararajan, Walter J. May, Graham C. von Schill, Dylan K. McLaughlin, Lisa A. Palmer, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Decreases in arterial blood oxygen stimulate increases in minute ventilation via activation of peripheral and central respiratory structures. This study evaluates the role of endothelial nitric oxide synthase (eNOS) in the expression of the
Externí odkaz:
https://doaj.org/article/aa8d9a37798f4dda8ad6274154755b44
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, James N. Bates, Christopher R. Ellis, Michael G. Feasel, Christopher G. Wilson, Tristan H. J. Lewis, Benjamin Gaston, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We are developing a series of thiolesters that produce an immediate and sustained reversal of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without diminishing the antinociceptive effects of these opioids. We repor
Externí odkaz:
https://doaj.org/article/58575678264d4a8ca9cc27c71351a745
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Tristan H.J. Lewis, James N. Bates, Yee-Hsee Hsieh, Benjamin Gaston, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113277- (2022)
There is an urgent need for development of drugs that are able to reverse the adverse effects of opioids on breathing and arterial blood-gas (ABG) chemistry while preserving opioid analgesia. The present study describes the effects of bolus injection
Externí odkaz:
https://doaj.org/article/6ff878c2816540d6af32fc989e5eb70a
Autor:
Paulina M. Getsy, Alex P. Young, James N. Bates, Santhosh M. Baby, James M. Seckler, Alan Grossfield, Yee-Hsee Hsieh, Tristan H.J. Lewis, Michael W. Jenkins, Benjamin Gaston, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113436- (2022)
S-nitrosothiols exert multiple effects on neural processes in the central and peripheral nervous system. This study shows that intravenous infusion of S-nitroso-L-cysteine (SNO-L-CYS, 1 μmol/kg/min) in anesthetized male Sprague Dawley rats elicits (
Externí odkaz:
https://doaj.org/article/6f97724f1ec6428e84a2ee15e0db6a50