Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Stephen J Lalor"'
Autor:
Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005226 (2015)
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using a murine model of recurrent
Externí odkaz:
https://doaj.org/article/6832261a8fdf4af4abe77367d6c1163a
Publikováno v:
Mucosal Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87cf61144436213b098a943b08c29c5
https://doi.org/10.1016/j.mucimm.2023.04.003
https://doi.org/10.1016/j.mucimm.2023.04.003
The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated. The airways have been linked with trafficking of myelin-specific T cells in the pre-clinical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b11202885041c87d66044263445dfeb
https://doi.org/10.1101/2023.03.30.534905
https://doi.org/10.1101/2023.03.30.534905
Autor:
Lucy M. Curham, Jenny M. Mannion, Clíodhna M. Daly, Mieszko M. Wilk, Lisa Borkner, Stephen J. Lalor, Rachel M. McLoughlin, Kingston H.G. Mills
Publikováno v:
European Journal of Immunology. 53
Tissue-resident memory CD4 T ($T_{RM}$) cells induced by infection with Bordetella pertussis persist in respiratory tissues and confer long-term protective immunity against re-infection. However, it is not clear how they are maintained in respiratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b391de8ef28df63fc366d340a9c520
https://doi.org/10.1002/eji.202250247
https://doi.org/10.1002/eji.202250247
Autor:
null Lucy M. Curham, null Jenny M. Mannion, null Clíodhna M. Daly, null Mieszko M. Wilk, null Lisa Borkner, null Stephen J. Lalor, null Rachel M. McLoughlin, null Kingston H.G. Mills
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5488a0ffffcfb7d969471b5a3f677cd5
https://doi.org/10.1002/eji.202250247/v2/response1
https://doi.org/10.1002/eji.202250247/v2/response1
Publikováno v:
J Immunol
Murine studies have shown the potential for γδ T cells to mediate immunity to Staphylococcus aureus in multiple tissue settings by the secretion of diverse cytokines. However, the role played by γδ T cells in human immune responses to S. aureus i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e050d22fa116c614e83d59f6b9c1ef9f
https://doi.org/10.4049/jimmunol.2000143
https://doi.org/10.4049/jimmunol.2000143
Autor:
Jesus Paez-Cortez, Paul G. Thomas, Song Baik, David Price, Karsten Hokamp, Sarah C. Edwards, Bruno Silva-Santos, Rachel M. McLoughlin, Stephen J. Lalor, Valerie Pivorunas, Caroline E. Sutton, Graham Anderson, Walid Awad, Barry Moran, Julie C. Ribot, James E. McLaren, Aoife M. McGinley, Anthony Slavin, Fiona M. Roche, Pradyot Dash, Kristin Ladell, Nopporn Apiwattanakul, Kingston H. G. Mills, Michael Macoritto, Kelly L. Miners, Lori Dowding, Emma J. Grant
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine
T cells classically express either αβ or γδ T cell receptors. We have identified T cells that express both pairs of receptors. These hybrid αβ-γδ T cells exhibit a hyperinflammatory and migratory phenotype and act as first responders in infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b959b0b0d180f391caec4c75edeeac7c
https://doi.org/10.1084/jem.20190834
https://doi.org/10.1084/jem.20190834
Autor:
Zbigniew Zaslona, Stephen J. Lalor, Anne M. Curtis, James O. Early, Rachel M. McLoughlin, Sarah Case, Luke A. J. O'Neill
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L855-L860
Our body clock drives rhythms in the expression of genes that have a 24-h periodicity. The transcription factor BMAL1 is a crucial component of the molecular clock. A number of physiological processes, including immune function, are modulated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0692827518ff7a3092ca7f72d7f46695
https://doi.org/10.1152/ajplung.00072.2017
https://doi.org/10.1152/ajplung.00072.2017
Autor:
Stephen J. Lalor, Rachel M. McLoughlin
Publikováno v:
Trends in Immunology. 37:690-702
Despite the potential for diversity in their T cell receptor, γδ T cells are primarily considered to be innate immune cells. Recently, memory-like γδ T cell responses have been identified in murine models of infection and autoimmunity. Similar me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8b12fc13fb2022d6581e21642094b7
https://doi.org/10.1016/j.it.2016.07.006
https://doi.org/10.1016/j.it.2016.07.006
Autor:
Stephen J. Lalor, Niamh McCormack, Rachel M. McLoughlin, Keenan A. Lacey, John Leech, Joan A. Geoghegan
Publikováno v:
Infection and Immunity
Staphylococcus aureus has become increasingly resistant to antibiotics, and vaccines offer a potential solution to this epidemic of antimicrobial resistance. Targeting of specific T cell subsets is now considered crucial for next-generation anti- S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186b48224669659fe897eb756806931a
http://europepmc.org/articles/PMC5695125
http://europepmc.org/articles/PMC5695125