Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Stephen J Kennel"'
Autor:
Stephen J Kennel, Joseph W Jackson, Alan Stuckey, Tina Richey, James S Foster, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301756 (2024)
IntroductionAmyloid deposition is a cause of restrictive cardiomyopathy. Patients who present with cardiac disease can be evaluated for transthyretin (TTR)-associated cardiac amyloidosis using nuclear imaging with 99mTc-labeled pyrophosphate (PYP); h
Externí odkaz:
https://doaj.org/article/ae00333921e540a68f07fb68eada90da
Autor:
Emily B Martin, Angela Williams, Craig Wooliver, R Eric Heidel, Sarah Adams, John Dunlap, Marina Ramirez-Alvarado, Luis M Blancas-Mejia, Ronald H Lands, Stephen J Kennel, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174152 (2017)
BACKGROUND:Monoclonal free light chain (LC) proteins are present in the circulation of patients with immunoproliferative disorders such as light chain (AL) amyloidosis and multiple myeloma (MM). Light chain-associated amyloid is a complex pathology c
Externí odkaz:
https://doaj.org/article/70a1e18a6c244bd991809094f706fbdf
Autor:
Helen P McWilliams-Koeppen, James S Foster, Nicole Hackenbrack, Marina Ramirez-Alvarado, Dallas Donohoe, Angela Williams, Sallie Macy, Craig Wooliver, Dale Wortham, Jennifer Morrell-Falvey, Carmen M Foster, Stephen J Kennel, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137716 (2015)
Light chain (AL) amyloidosis is the most common form of systemic amyloid disease, and cardiomyopathy is a dire consequence, resulting in an extremely poor prognosis. AL is characterized by the production of monoclonal free light chains that deposit a
Externí odkaz:
https://doaj.org/article/7182f06f22c546f9ac3476127cafd2be
Autor:
Pranay Dogra, Emily B Martin, Angela Williams, Raphael L Richardson, James S Foster, Nicole Hackenback, Stephen J Kennel, Tim E Sparer, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126239 (2015)
Human cytomegalovirus (HCMV) infection can lead to congenital hearing loss and mental retardation. Upon immune suppression, reactivation of latent HCMV or primary infection increases morbidity in cancer, transplantation, and late stage AIDS patients.
Externí odkaz:
https://doaj.org/article/02856b0633474fbfa83ccefa93f6dfdf
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122780 (2015)
This paper addresses 123I and 125I dual isotope SPECT imaging, which can be challenging because of spectrum overlap in the low energy spectrums of these isotopes. We first quantify the contribution of low-energy photons from each isotope using GATE-b
Externí odkaz:
https://doaj.org/article/2970637d89404dc1910043440d33bc86
Autor:
Mark F McLaughlin, Jonathan Woodward, Rose A Boll, Jonathan S Wall, Adam J Rondinone, Stephen J Kennel, Saed Mirzadeh, J David Robertson
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54531 (2013)
Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge wi
Externí odkaz:
https://doaj.org/article/1a3a1583aa87460787fc214aaf7959c6
Autor:
Jonathan S Wall, Angela Williams, Tina Richey, Alan Stuckey, Ying Huang, Craig Wooliver, Sallie Macy, Eric Heidel, Neil Gupta, Angela Lee, Brianna Rader, Emily B Martin, Stephen J Kennel
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66181 (2013)
Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer's disease, type 2 diabetes, rheumatoid arthritis, and myeloma. The distribution and extent of amyloid deposition in body organs establishes the prognosis
Externí odkaz:
https://doaj.org/article/0b5f2c1bf4a044cbb5c5cf4fa589166e
Autor:
Jonathan S Wall, Stephen J Kennel, Angela Williams, Tina Richey, Alan Stuckey, Ying Huang, Sallie Macy, Robert Donnell, Robin Barbour, Peter Seubert, Dale Schenk
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52686 (2012)
The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum amyloid protein A (sAA) containing a -Glu-Asp- amino acid pairing. In addition to its reactivity with sAA amyloid deposits, the antibody was also found to bind amyloid
Externí odkaz:
https://doaj.org/article/1ffe065ab13e43e99ff425143f1fbae9
Autor:
Jonathan S Wall, Stephen J Kennel, Tina eRichey, Amy eAllen, Alan eStuckey, Deborah T Weiss, Sallie D Macy, Robin eBarbour, Peter eSeubert, Alan eSolomon, Dale eSchenk
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
AA amyloidosis results from the pathologic deposition in the kidneys and other organs of fibrils composed of N-terminal fragments of serum amyloid A protein (SAA). Given that there are only limited means to visualize these deposits, we have developed
Externí odkaz:
https://doaj.org/article/7cfe2d04166f4f87bcc8dde5821b273f
Autor:
Joseph W. Jackson, James S. Foster, Emily B. Martin, Sallie Macy, Craig Wooliver, Manasi Balachandran, Tina Richey, R. Eric Heidel, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Amyloid. :1-12